Detalhe da pesquisa
1.
Newly developed oral bioavailable EHMT2 inhibitor as a potential epigenetic therapy for Prader-Willi syndrome.
Mol Ther
; 2024 May 24.
Artigo
Inglês
| MEDLINE | ID: mdl-38796700
2.
A cryptic transactivation domain of EZH2 binds AR and AR's splice variant, promoting oncogene activation and tumorous transformation.
Nucleic Acids Res
; 50(19): 10929-10946, 2022 10 28.
Artigo
Inglês
| MEDLINE | ID: mdl-36300627
3.
Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets.
J Am Chem Soc
; 144(49): 22622-22632, 2022 12 14.
Artigo
Inglês
| MEDLINE | ID: mdl-36448571
4.
Discovery of a first-in-class EZH2 selective degrader.
Nat Chem Biol
; 16(2): 214-222, 2020 02.
Artigo
Inglês
| MEDLINE | ID: mdl-31819273
5.
Assessment of organochlorine pesticides in the atmosphere of South Korea: spatial distribution, seasonal variation, and sources.
Environ Monit Assess
; 194(10): 754, 2022 Sep 09.
Artigo
Inglês
| MEDLINE | ID: mdl-36083375
6.
Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation.
J Am Chem Soc
; 143(37): 15073-15083, 2021 09 22.
Artigo
Inglês
| MEDLINE | ID: mdl-34520194
7.
Structure-Based Design, Docking and Binding Free Energy Calculations of A366 Derivatives as Spindlin1 Inhibitors.
Int J Mol Sci
; 22(11)2021 May 31.
Artigo
Inglês
| MEDLINE | ID: mdl-34072837
8.
A Novel Probe with a Chlorinated α-Cyanoacetophenone Acceptor Moiety Shows Near-Infrared Fluorescence Specific for Tau Fibrils.
Chem Pharm Bull (Tokyo)
; 65(12): 1113-1116, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-29199217
9.
Dicyanovinyl-substituted J147 analogue inhibits oligomerization and fibrillation of ß-amyloid peptides and protects neuronal cells from ß-amyloid-induced cytotoxicity.
Org Biomol Chem
; 13(37): 9564-9, 2015 Oct 07.
Artigo
Inglês
| MEDLINE | ID: mdl-26303522
10.
A curcumin-based molecular probe for near-infrared fluorescence imaging of tau fibrils in Alzheimer's disease.
Org Biomol Chem
; 13(46): 11194-9, 2015 Dec 14.
Artigo
Inglês
| MEDLINE | ID: mdl-26488450
11.
Metabolic engineering of Escherichia coli for the biosynthesis of flavonoid-O-glucuronides and flavonoid-O-galactoside.
Appl Microbiol Biotechnol
; 99(5): 2233-42, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-25515812
12.
Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2.
Eur J Med Chem
; 267: 116154, 2024 Mar 05.
Artigo
Inglês
| MEDLINE | ID: mdl-38295690
13.
Discovery and Characterization of a Novel Cereblon-Recruiting PRC1 Bridged PROTAC Degrader.
J Med Chem
; 67(8): 6880-6892, 2024 Apr 25.
Artigo
Inglês
| MEDLINE | ID: mdl-38607318
14.
Discovery of the First-in-class G9a/GLP PROTAC Degrader.
bioRxiv
; 2024 Feb 29.
Artigo
Inglês
| MEDLINE | ID: mdl-38464025
15.
Discovery of the First-in-Class G9a/GLP PROTAC Degrader.
J Med Chem
; 67(8): 6397-6409, 2024 Apr 25.
Artigo
Inglês
| MEDLINE | ID: mdl-38602846
16.
Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor.
J Med Chem
; 67(7): 5837-5853, 2024 Apr 11.
Artigo
Inglês
| MEDLINE | ID: mdl-38533580
17.
Quercetin-POC conjugates: Differential stability and bioactivity profiles between breast cancer (MCF-7) and colorectal carcinoma (HCT116) cell lines.
Bioorg Med Chem
; 21(7): 1671-9, 2013 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23434132
18.
Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy.
Adv Sci (Weinh)
; 10(10): e2205573, 2023 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36737841
19.
Novel brain-penetrant inhibitor of G9a methylase blocks Alzheimer's disease proteopathology for precision medication.
Res Sq
; 2023 Nov 21.
Artigo
Inglês
| MEDLINE | ID: mdl-38045363
20.
Novel brain-penetrant inhibitor of G9a methylase blocks Alzheimer's disease proteopathology for precision medication.
medRxiv
; 2023 Oct 26.
Artigo
Inglês
| MEDLINE | ID: mdl-37961307