[Cross sectional study of comorbidities and concomitant medications in a cohort of human immunodeficiency virus-infected patients]. / Estudio transversal de comorbilidades y medicaciones concomitantes en una cohorte de pacientes infectados por el virus de la inmunodeficiencia humana.

AIM: To assess the prevalence of comorbidities, concomitant therapies and adverse effects associated with the medication in a cohort of patients with HIV infection. DESIGN: Multicentre cross-sectional study. SETTINGS: Infectious Diseases or Internal Medicine outpatient Clinics of 3 hospitals in the Basque Country. PARTICIPANTS: During a 3 month period, patients with the following inclusion criteria were randomly selected: HIV infection, age>18years, antiretroviral treatment (ART) for at least 6months, and no changes in ART in the previous 4weeks. A total of 224 patients (of the 225 expected) were included. MEASUREMENTS: Data were collected using a form, and include, epidemiological and anthropometric data, data related to HIV infection, comorbidities, current therapies, and adverse effects. RESULTS: Of the 224 patients, 95.5% had at least one comorbidity, the most common being HCV infection (51.3%), dyslipidaemia (37.9%), diabetes mellitus or impaired fasting glucose (21.9%), and hypertension (21.9%). A total of 155 patients (69.2%) were taking concomitant medication: anxiolytics (21.4%), antihypertensives (19.6%), proton pump inhibitors (17.9%), statins (17%), and antidepressants (16.5%). Adverse effects (AE) were observed in 62.9% of subjects, the most common being, changes in body fat distribution (32.6%) and gastrointestinal (24.1%). CONCLUSIONS: Patients with HIV infection are getting older, with more comorbidities, with very frequent use of concomitant treatments, and high number of adverse effects. This requires a multidisciplinary approach and a coordinated effort within the Primary Care setting.

Estudio transversal de comorbilidades y medicaciones concomitantes en una cohorte de pacientes infectados por el virus de la inmunodeficiencia humana / Cross sectional study of comorbidities and concomitant medications in a cohort of human immunodeficiency virus-infected patients

OBJETIVO: Valorar la prevalencia de comorbilidades, tratamientos concomitantes y episodios adversos asociados a la medicación en una cohorte de pacientes con infección por VIH. DISEÑO: Estudio transversal multicéntrico. Emplazamiento: Consultas externas especializadas del servicio de Enfermedades Infecciosas o Medicina Interna de 3 hospitales de la comunidad autónoma del País Vasco. PARTICIPANTES: Durante 3 meses se seleccionaron de forma aleatoria pacientes con los siguientes criterios de inclusión: infección por VIH, edad superior a 18años, tratamiento antirretroviral (TAR) desde al menos 6meses y pauta de TAR estable las últimas 4semanas. Se incluyeron 224 pacientes del total de 225 previstos. Mediciones principales: Se recogieron mediante formulario datos epidemiológicos y antropométricos relativos a la infección por VIH, comorbilidades, tratamientos concomitantes y episodios adversos. RESULTADOS: El 95,5% de los pacientes presentaban alguna comorbilidad, siendo las más frecuentes: infección por VHC (51,3%), dislipidemias (37,9%), glucemia basal alterada o diabetes mellitus (21,9%) e hipertensión arterial (21,9%). El 69,2% tomaban alguna medicación concomitante al TAR: ansiolíticos (21,4%), antihipertensivos (19,6%), inhibidores de la bomba de protones (17,9%), estatinas (17%) o antidepresivos (16,5%). El 62,9% presentaban algún efecto adverso, los más frecuentes la alteración de la distribución de grasa corporal (32,6%) y digestivos (24,1%). CONCLUSIONES: Nuestros pacientes con infección por VIH son cada vez mayores, con mayor número de comorbilidades, con uso muy frecuente de tratamientos concomitantes y elevada prevalencia de episodios adversos. Esto obliga a un abordaje multidisciplinar y a una labor coordinada con atención primaria

AIM: To assess the prevalence of comorbidities, concomitant therapies and adverse effects associated with the medication in a cohort of patients with HIV infection. DESIGN: Multicentre cross-sectional study. Settings: Infectious Diseases or Internal Medicine outpatient Clinics of 3 hospitals in the Basque Country. PARTICIPANTS: During a 3 month period, patients with the following inclusion criteria were randomly selected: HIV infection, age>18years, antiretroviral treatment (ART) for at least 6months, and no changes in ART in the previous 4weeks. A total of 224 patients (of the 225 expected) were included. Measurements: Data were collected using a form, and include, epidemiological and anthropometric data, data related to HIV infection, comorbidities, current therapies, and adverse effects. RESULTS: Of the 224 patients, 95.5% had at least one comorbidity, the most common being HCV infection (51.3%), dyslipidaemia (37.9%), diabetes mellitus or impaired fasting glucose (21.9%), and hypertension (21.9%). A total of 155 patients (69.2%) were taking concomitant medication: anxiolytics (21.4%), antihypertensives (19.6%), proton pump inhibitors (17.9%), statins (17%), and antidepressants (16.5%). Adverse effects (AE) were observed in 62.9% of subjects, the most common being, changes in body fat distribution (32.6%) and gastrointestinal (24.1%). CONCLUSIONS: Patients with HIV infection are getting older, with more comorbidities, with very frequent use of concomitant treatments, and high number of adverse effects. This requires a multidisciplinary approach and a coordinated effort within the Primary Care setting