RESUMO
We studied the occipital inter-hemispheric coherence (IHCoh) of EEG (electrodes O1-O2) for alpha band (alpha1 - 8,0 to 10,0 Hz and alpha2 - 10,1 to 12,5 Hz) in healthy adults and Alzheimer's type dementia (ATD) subjects, to observe if there is any significant difference between these two groups that could help in the early diagnosis of ATD. We found a decrease of occipital IHCoh in ATD group for both alpha sub-bands. We believe that Coh analysis of EEG is a powerful auxiliary method in ATD diagnosis.
Assuntos
Doença de Alzheimer/diagnóstico , Eletroencefalografia/métodos , Ritmo alfa , Doença de Alzheimer/fisiopatologia , Estudos de Casos e Controles , Diagnóstico Diferencial , Estudos de Avaliação como Assunto , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
A non-familiar case of Kiloh-Nevin ocular myopathy with important histochemical and ultrastructural abnormalities is reported. The patient, a 43 year-old male presented with 10 year long, pregressive ocular ophtalmoplegia, myasthenic symptoms and severe muscular pain, an uncommon finding in this type of myopathy. The histochemical study showed muscular atrophy, mainly in type I fibres and a great amount of ragged-red fibres. Of particular interest, in this case, was the ultrastructural finding of severe mitochondrial abnormalities with a lot of inclusions in the cristae matrix; nevertheless these changes are not specific. The authors suggest a possible abnormality in the neuro-muscular transmission system and a genetically controlled enzimatic factor as responsible for the aethiology and pathogenesis of the Kiloh-Nevin ocular myopathy.
Assuntos
Blefaroptose/patologia , Músculos Oculomotores/patologia , Oftalmoplegia/patologia , Adulto , Biópsia , Histocitoquímica , Humanos , Masculino , Microscopia Eletrônica , Mitocôndrias Musculares/ultraestrutura , Doenças Musculares/patologia , Músculos Oculomotores/ultraestrutura , Dor , Transmissão SinápticaRESUMO
Case report of a 7 1/2-year-old girl considered as being normal until the age of 2 years. From then on she progressed with gait disturbance, mental deterioration, dystonic movements, convulsions and dysarthria. She died of bronchopneumonia one year later. CT scan showed hyperdensity at the putamen, with no signs of cerebral atrophy. Pathological examination disclosed an intense red coloration of the putamen and axonal "spheroids" at electron microscopy.
Assuntos
Axônios/ultraestrutura , Doenças dos Gânglios da Base/patologia , Neurodegeneração Associada a Pantotenato-Quinase/patologia , Criança , Feminino , Humanos , Neurodegeneração Associada a Pantotenato-Quinase/fisiopatologia , Tomografia Computadorizada por Raios XRESUMO
A síndrome de Hallervorden-Spatz bem como a distrofia neuroaxonal infantil säo patologias raras e os limites entre ambas säo ainda imprecisos. Apresentamos o caso de menina de 7 anos e meio com rebaixamento mental, distonia, crises convulsivas e coriorretinite. CT mostrava hiperdensidade dos putâmens, sem sinais de atrofia cerebral. Ao exame anatomopatológicos observou-se intensa coloraçäo avermelhada dos putâmens, porém com ausência de pigmento férrico. A microscopia eletrônica foram observados os <>