A Universal Approximation for Conductance Blockade in Thin Nanopore Membranes.

Nanopore-based sensing platforms have transformed single-molecule detection and analysis. The foundation of nanopore translocation experiments lies in conductance measurements, yet existing models, which are largely phenomenological, are inaccurate in critical experimental conditions such as thin and tightly fitting pores. Of the two components of the conductance blockade, channel and access resistance, the access resistance is poorly modeled. We present a comprehensive investigation of the access resistance and associated conductance blockade in thin nanopore membranes. By combining a first-principles approach, multiscale modeling, and experimental validation, we propose a unified theoretical modeling framework. The analytical model derived as a result surpasses current approaches across a broad parameter range. Beyond advancing our theoretical understanding, our framework's versatility enables analyte size inference and predictive insights into conductance blockade behavior. Our results will facilitate the design and optimization of nanopore devices for diverse applications, including nanopore base calling and data storage.

Molecular Investigation of the Actuation of Electrowetted Nanodroplets.

It is well known that the wettability of a droplet on a solid substrate can be modified by the application of an electric field. The phenomenon of electrowetting along with the associated physics of droplet shape change and dynamics has traditionally been studied at the micro-scale leading to exciting applications. The present work is undertaken to explore the physics of electrowetting actuation of droplet movement at the molecular level. Molecular simulations are performed to obtain the dynamic spreading of the droplet under the action of a radially symmetric electric field on a silica substrate. The dynamic behavior of the contact diameter is found to be qualitatively similar to that observed at the laboratory scale. Further simulations of droplet actuation across an array of electrodes illustrated the dynamics of the center of mass, which is then used to estimate the contact line friction and compared with the predictions from a reduced-order model. A scaling analysis is used to probe the physics of the problem correlating the contact line friction coefficient and the droplet velocity after actuation. The results and understanding elicited from the fundamental approach have the potential to guide the development of quick and precise control of nano-sized droplets and may prove to be pivotal in the development of future nanofluidic systems, nanomanufacturing methodologies, and high-resolution optoelectronic devices.

Molecular Investigation of Contact Line Movement in Electrowetted Nanodroplets.

Molecular dynamics (MD) simulation of an electrowetted nanodroplet is performed to understand the fundamental origin of the involved parameters resulted from the molecular movement in the vicinity of the three-phase contact line (TPCL). During the spreading of the droplet, contact line friction (CLF) force is found to be the controlling one among all other resistive forces. Being molecular in nature, MD study is required to unveil the CLF, which is manifested by the TPCL friction coefficient ζ. The combined effect of temperature, electric field, and surface wettability, manifested by the solid-liquid Lennard-Jones interaction parameter, is studied to explore the droplet spreading. The entire droplet wetting dynamics is divided into two different regimes, namely, spreading regime and equilibrium regime. The molecular frequency during the TPCL movement in the equilibrium regime is affected by the presence of any external perturbation and results in an alteration of ζ. The predetermined knowledge of the alteration of CLF due to the coupling effect of electric field and temperature will have a potential application towards designing electric field-inspired droplet movement devices.