Detalhe da pesquisa
1.
Ligand-Induced Activation of GPR110 (ADGRF1) to Improve Visual Function Impaired by Optic Nerve Injury.
Int J Mol Sci
; 24(6)2023 Mar 10.
Artigo
Inglês
| MEDLINE | ID: mdl-36982411
2.
Virtual Screening for the Discovery of Microbiome ß-Glucuronidase Inhibitors to Alleviate Cancer Drug Toxicity.
J Chem Inf Model
; 62(7): 1783-1793, 2022 04 11.
Artigo
Inglês
| MEDLINE | ID: mdl-35357819
3.
Discovery of Small-Molecule VapC1 Nuclease Inhibitors by Virtual Screening and Scaffold Hopping from an Atomic Structure Revealing Protein-Protein Interactions with a Native VapB1 Inhibitor.
J Chem Inf Model
; 62(5): 1249-1258, 2022 03 14.
Artigo
Inglês
| MEDLINE | ID: mdl-35103473
4.
Ligand-Induced GPR110 Activation Facilitates Axon Growth after Injury.
Int J Mol Sci
; 22(7)2021 Mar 25.
Artigo
Inglês
| MEDLINE | ID: mdl-33806166
5.
Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis.
FASEB J
; 33(11): 12435-12446, 2019 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31419161
6.
Safety assessment of metarrestin in dogs: A clinical candidate targeting a subnuclear structure unique to metastatic cancer cells.
Regul Toxicol Pharmacol
; 116: 104716, 2020 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-32619635
7.
Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists.
Bioorg Med Chem Lett
; 29(9): 1113-1119, 2019 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30852083
8.
Activation of ß-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.
J Neurosci
; 36(29): 7693-706, 2016 07 20.
Artigo
Inglês
| MEDLINE | ID: mdl-27445146
9.
A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism.
J Neurosci
; 36(28): 7441-52, 2016 07 13.
Artigo
Inglês
| MEDLINE | ID: mdl-27413154
10.
Progress and potential of non-inhibitory small molecule chaperones for the treatment of Gaucher disease and its implications for Parkinson disease.
Expert Rev Proteomics
; 13(5): 471-9, 2016 05.
Artigo
Inglês
| MEDLINE | ID: mdl-27098312
11.
Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects.
Nucleic Acids Res
; 42(10): 6591-602, 2014 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-24799433
12.
Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration.
J Biol Chem
; 289(23): 16349-61, 2014 Jun 06.
Artigo
Inglês
| MEDLINE | ID: mdl-24755226
13.
A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats.
J Neurosci
; 33(24): 10132-42, 2013 Jun 12.
Artigo
Inglês
| MEDLINE | ID: mdl-23761908
14.
An electrophilic fragment screening for the development of small molecules targeting caspase-2.
Eur J Med Chem
; 259: 115632, 2023 Nov 05.
Artigo
Inglês
| MEDLINE | ID: mdl-37453329
15.
Target Class Profiling of Small-Molecule Methyltransferases.
ACS Chem Biol
; 18(4): 969-981, 2023 04 21.
Artigo
Inglês
| MEDLINE | ID: mdl-36976909
16.
Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration.
Autophagy Rep
; 2(1)2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37064812
17.
SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers.
Nat Cancer
; 4(3): 365-381, 2023 03.
Artigo
Inglês
| MEDLINE | ID: mdl-36914816
18.
Selective Inhibitors of Autophagy Reveal New Link between the Cell Cycle and Autophagy and Lead to Discovery of Novel Synergistic Drug Combinations.
ACS Chem Biol
; 17(12): 3290-3297, 2022 12 16.
Artigo
Inglês
| MEDLINE | ID: mdl-36469692
19.
Teaching principles of translational science to a broad scientific audience using a case study approach: A pilot course from the National Center for Advancing Translational Sciences.
J Clin Transl Sci
; 6(1): e66, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35754433
20.
Discovery of Novel Small-Molecule Scaffolds for the Inhibition and Activation of WIP1 Phosphatase from a RapidFire Mass Spectrometry High-Throughput Screen.
ACS Pharmacol Transl Sci
; 5(10): 993-1006, 2022 Oct 14.
Artigo
Inglês
| MEDLINE | ID: mdl-36268125