Pesquisa | Secretaria de Estado da Saúde

1.

Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation.

Miao, Weili; Porter, Douglas F; Lopez-Pajares, Vanessa; Siprashvili, Zurab; Meyers, Robin M; Bai, Yunhao; Nguyen, Duy T; Ko, Lisa A; Zarnegar, Brian J; Ferguson, Ian D; Mills, Matthew M; Jilly-Rehak, Christie E; Wu, Cheng-Guo; Yang, Yen-Yu; Meyers, Jordan M; Hong, Audrey W; Reynolds, David L; Ramanathan, Muthukumar; Tao, Shiying; Jiang, Sizun; Flynn, Ryan A; Wang, Yinsheng; Nolan, Garry P; Khavari, Paul A.

Cell ; 186(1): 80-97.e26, 2023 01 05.

Artigo Inglês | MEDLINE | ID: mdl-36608661

2.

High-resolution analyses of associations between medications, microbiome, and mortality in cancer patients.

Nguyen, Chi L; Markey, Kate A; Miltiadous, Oriana; Dai, Anqi; Waters, Nicholas; Sadeghi, Keimya; Fei, Teng; Shouval, Roni; Taylor, Bradford P; Liao, Chen; Slingerland, John B; Slingerland, Ann E; Clurman, Annelie G; Maloy, Molly A; Bohannon, Lauren; Giardina, Paul A; Brereton, Daniel G; Armijo, Gabriel K; Fontana, Emily; Gradissimo, Ana; Gyurkocza, Boglarka; Sung, Anthony D; Chao, Nelson J; Devlin, Sean M; Taur, Ying; Giralt, Sergio A; Perales, Miguel-Angel; Xavier, Joao B; Pamer, Eric G; Peled, Jonathan U; Gomes, Antonio L C; van den Brink, Marcel R M.

Cell ; 186(12): 2705-2718.e17, 2023 06 08.

Artigo Inglês | MEDLINE | ID: mdl-37295406

3.

Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19.

Hanson, Aimee L; Mulè, Matthew P; Ruffieux, Hélène; Mescia, Federica; Bergamaschi, Laura; Pelly, Victoria S; Turner, Lorinda; Kotagiri, Prasanti; Göttgens, Berthold; Hess, Christoph; Gleadall, Nicholas; Bradley, John R; Nathan, James A; Lyons, Paul A; Drakesmith, Hal; Smith, Kenneth G C.

Nat Immunol ; 25(3): 471-482, 2024 Mar.

Artigo Inglês | MEDLINE | ID: mdl-38429458

4.

An expanded universe of cancer targets.

Hahn, William C; Bader, Joel S; Braun, Theodore P; Califano, Andrea; Clemons, Paul A; Druker, Brian J; Ewald, Andrew J; Fu, Haian; Jagu, Subhashini; Kemp, Christopher J; Kim, William; Kuo, Calvin J; McManus, Michael; B Mills, Gordon; Mo, Xiulei; Sahni, Nidhi; Schreiber, Stuart L; Talamas, Jessica A; Tamayo, Pablo; Tyner, Jeffrey W; Wagner, Bridget K; Weiss, William A; Gerhard, Daniela S.

Cell ; 184(5): 1142-1155, 2021 03 04.

Artigo Inglês | MEDLINE | ID: mdl-33667368

5.

Autism-related dietary preferences mediate autism-gut microbiome associations.

Yap, Chloe X; Henders, Anjali K; Alvares, Gail A; Wood, David L A; Krause, Lutz; Tyson, Gene W; Restuadi, Restuadi; Wallace, Leanne; McLaren, Tiana; Hansell, Narelle K; Cleary, Dominique; Grove, Rachel; Hafekost, Claire; Harun, Alexis; Holdsworth, Helen; Jellett, Rachel; Khan, Feroza; Lawson, Lauren P; Leslie, Jodie; Frenk, Mira Levis; Masi, Anne; Mathew, Nisha E; Muniandy, Melanie; Nothard, Michaela; Miller, Jessica L; Nunn, Lorelle; Holtmann, Gerald; Strike, Lachlan T; de Zubicaray, Greig I; Thompson, Paul M; McMahon, Katie L; Wright, Margaret J; Visscher, Peter M; Dawson, Paul A; Dissanayake, Cheryl; Eapen, Valsamma; Heussler, Helen S; McRae, Allan F; Whitehouse, Andrew J O; Wray, Naomi R; Gratten, Jacob.

Cell ; 184(24): 5916-5931.e17, 2021 11 24.

Artigo Inglês | MEDLINE | ID: mdl-34767757

6.

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption.

McDonald, Michelle M; Khoo, Weng Hua; Ng, Pei Ying; Xiao, Ya; Zamerli, Jad; Thatcher, Peter; Kyaw, Wunna; Pathmanandavel, Karrnan; Grootveld, Abigail K; Moran, Imogen; Butt, Danyal; Nguyen, Akira; Corr, Alexander; Warren, Sean; Biro, Maté; Butterfield, Natalie C; Guilfoyle, Siobhan E; Komla-Ebri, Davide; Dack, Michael R G; Dewhurst, Hannah F; Logan, John G; Li, Yongxiao; Mohanty, Sindhu T; Byrne, Niall; Terry, Rachael L; Simic, Marija K; Chai, Ryan; Quinn, Julian M W; Youlten, Scott E; Pettitt, Jessica A; Abi-Hanna, David; Jain, Rohit; Weninger, Wolfgang; Lundberg, Mischa; Sun, Shuting; Ebetino, Frank H; Timpson, Paul; Lee, Woei Ming; Baldock, Paul A; Rogers, Michael J; Brink, Robert; Williams, Graham R; Bassett, J H Duncan; Kemp, John P; Pavlos, Nathan J; Croucher, Peter I; Phan, Tri Giang.

Cell ; 184(5): 1330-1347.e13, 2021 03 04.

Artigo Inglês | MEDLINE | ID: mdl-33636130

7.

CTLA-4 tail fusion enhances CAR-T antitumor immunity.

Zhou, Xiaoyu; Cao, Hanbing; Fang, Shao-Yu; Chow, Ryan D; Tang, Kaiyuan; Majety, Medha; Bai, Meizhu; Dong, Matthew B; Renauer, Paul A; Shang, Xingbo; Suzuki, Kazushi; Levchenko, Andre; Chen, Sidi.

Nat Immunol ; 24(9): 1499-1510, 2023 09.

Artigo Inglês | MEDLINE | ID: mdl-37500885

8.

A patient-centric modeling framework captures recovery from SARS-CoV-2 infection.

Ruffieux, Hélène; Hanson, Aimee L; Lodge, Samantha; Lawler, Nathan G; Whiley, Luke; Gray, Nicola; Nolan, Tui H; Bergamaschi, Laura; Mescia, Federica; Turner, Lorinda; de Sa, Aloka; Pelly, Victoria S; Kotagiri, Prasanti; Kingston, Nathalie; Bradley, John R; Holmes, Elaine; Wist, Julien; Nicholson, Jeremy K; Lyons, Paul A; Smith, Kenneth G C; Richardson, Sylvia; Bantug, Glenn R; Hess, Christoph.

Nat Immunol ; 24(2): 349-358, 2023 02.

Artigo Inglês | MEDLINE | ID: mdl-36717723

9.

Adrenergic Signaling in Muscularis Macrophages Limits Infection-Induced Neuronal Loss.

Matheis, Fanny; Muller, Paul A; Graves, Christina L; Gabanyi, Ilana; Kerner, Zachary J; Costa-Borges, Diego; Ahrends, Tomasz; Rosenstiel, Philip; Mucida, Daniel.

Cell ; 180(1): 64-78.e16, 2020 01 09.

Artigo Inglês | MEDLINE | ID: mdl-31923400

10.

Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma.

Ji, Andrew L; Rubin, Adam J; Thrane, Kim; Jiang, Sizun; Reynolds, David L; Meyers, Robin M; Guo, Margaret G; George, Benson M; Mollbrink, Annelie; Bergenstråhle, Joseph; Larsson, Ludvig; Bai, Yunhao; Zhu, Bokai; Bhaduri, Aparna; Meyers, Jordan M; Rovira-Clavé, Xavier; Hollmig, S Tyler; Aasi, Sumaira Z; Nolan, Garry P; Lundeberg, Joakim; Khavari, Paul A.

Cell ; 182(2): 497-514.e22, 2020 07 23.

Artigo Inglês | MEDLINE | ID: mdl-32579974

11.

Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks.

Rubin, Adam J; Parker, Kevin R; Satpathy, Ansuman T; Qi, Yanyan; Wu, Beijing; Ong, Alvin J; Mumbach, Maxwell R; Ji, Andrew L; Kim, Daniel S; Cho, Seung Woo; Zarnegar, Brian J; Greenleaf, William J; Chang, Howard Y; Khavari, Paul A.

Cell ; 176(1-2): 361-376.e17, 2019 01 10.

Artigo Inglês | MEDLINE | ID: mdl-30580963

12.

A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9.

Maji, Basudeb; Gangopadhyay, Soumyashree A; Lee, Miseon; Shi, Mengchao; Wu, Peng; Heler, Robert; Mok, Beverly; Lim, Donghyun; Siriwardena, Sachini U; Paul, Bishwajit; Dancík, Vlado; Vetere, Amedeo; Mesleh, Michael F; Marraffini, Luciano A; Liu, David R; Clemons, Paul A; Wagner, Bridget K; Choudhary, Amit.

Cell ; 177(4): 1067-1079.e19, 2019 05 02.

Artigo Inglês | MEDLINE | ID: mdl-31051099

13.

Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells.

Dong, Matthew B; Wang, Guangchuan; Chow, Ryan D; Ye, Lupeng; Zhu, Lvyun; Dai, Xiaoyun; Park, Jonathan J; Kim, Hyunu R; Errami, Youssef; Guzman, Christopher D; Zhou, Xiaoyu; Chen, Krista Y; Renauer, Paul A; Du, Yaying; Shen, Johanna; Lam, Stanley Z; Zhou, Jingjia J; Lannin, Donald R; Herbst, Roy S; Chen, Sidi.

Cell ; 178(5): 1189-1204.e23, 2019 08 22.

Artigo Inglês | MEDLINE | ID: mdl-31442407

14.

Autism-related dietary preferences mediate autism-gut microbiome associations.

Yap, Chloe X; Henders, Anjali K; Alvares, Gail A; Wood, David L A; Krause, Lutz; Tyson, Gene W; Restuadi, Restuadi; Wallace, Leanne; McLaren, Tiana; Hansell, Narelle K; Cleary, Dominique; Grove, Rachel; Hafekost, Claire; Harun, Alexis; Holdsworth, Helen; Jellett, Rachel; Khan, Feroza; Lawson, Lauren P; Leslie, Jodie; Frenk, Mira Levis; Masi, Anne; Mathew, Nisha E; Muniandy, Melanie; Nothard, Michaela; Miller, Jessica L; Nunn, Lorelle; Holtmann, Gerald; Strike, Lachlan T; de Zubicaray, Greig I; Thompson, Paul M; McMahon, Katie L; Wright, Margaret J; Visscher, Peter M; Dawson, Paul A; Dissanayake, Cheryl; Eapen, Valsamma; Heussler, Helen S; McRae, Allan F; Whitehouse, Andrew J O; Wray, Naomi R; Gratten, Jacob.

Cell ; 187(2): 495-510, 2024 Jan 18.

Artigo Inglês | MEDLINE | ID: mdl-38242089

15.

The CD8⁺ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects.

Van Der Byl, Willem; Nüssing, Simone; Peters, Timothy J; Ahn, Antonio; Li, Hanjie; Ledergor, Guy; David, Eyal; Koh, Andrew S; Wagle, Mayura V; Deguit, Christian Deo T; de Menezes, Maria N; Travers, Avraham; Sampurno, Shienny; Ramsbottom, Kelly M; Li, Rui; Kallies, Axel; Beavis, Paul A; Jungmann, Ralf; Bastings, Maartje M C; Belz, Gabrielle T; Goel, Shom; Trapani, Joseph A; Crabtree, Gerald R; Chang, Howard Y; Amit, Ido; Goodnow, Chris C; Luciani, Fabio; Parish, Ian A.

Immunity ; 2024 May 16.

Artigo Inglês | MEDLINE | ID: mdl-38776918

16.

Bifunctional Immunity Proteins Protect Bacteria against FtsZ-Targeting ADP-Ribosylating Toxins.

Ting, See-Yeun; Bosch, Dustin E; Mangiameli, Sarah M; Radey, Matthew C; Huang, Shuo; Park, Young-Jun; Kelly, Katherine A; Filip, Szymon Krzysztof; Goo, Young Ah; Eng, Jimmy K; Allaire, Marc; Veesler, David; Wiggins, Paul A; Peterson, S Brook; Mougous, Joseph D.

Cell ; 175(5): 1380-1392.e14, 2018 11 15.

Artigo Inglês | MEDLINE | ID: mdl-30343895

17.

Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development.

Burrows, Natalie; Bashford-Rogers, Rachael J M; Bhute, Vijesh J; Peñalver, Ana; Ferdinand, John R; Stewart, Benjamin J; Smith, Joscelin E G; Deobagkar-Lele, Mukta; Giudice, Girolamo; Connor, Thomas M; Inaba, Akimichi; Bergamaschi, Laura; Smith, Sam; Tran, Maxine G B; Petsalaki, Evangelia; Lyons, Paul A; Espeli, Marion; Huntly, Brian J P; Smith, Kenneth G C; Cornall, Richard J; Clatworthy, Menna R; Maxwell, Patrick H.

Nat Immunol ; 21(11): 1408-1420, 2020 11.

Artigo Inglês | MEDLINE | ID: mdl-32868930

18.

Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity.

Lai, Junyun; Mardiana, Sherly; House, Imran G; Sek, Kevin; Henderson, Melissa A; Giuffrida, Lauren; Chen, Amanda X Y; Todd, Kirsten L; Petley, Emma V; Chan, Jack D; Carrington, Emma M; Lew, Andrew M; Solomon, Benjamin J; Trapani, Joseph A; Kedzierska, Katherine; Evrard, Maximilien; Vervoort, Stephin J; Waithman, Jason; Darcy, Phillip K; Beavis, Paul A.

Nat Immunol ; 21(8): 914-926, 2020 08.

Artigo Inglês | MEDLINE | ID: mdl-32424363

19.

A transcriptionally distinct subset of influenza-specific effector memory B cells predicts long-lived antibody responses to vaccination in humans.

Nellore, Anoma; Zumaquero, Esther; Scharer, Christopher D; Fucile, Christopher F; Tipton, Christopher M; King, R Glenn; Mi, Tian; Mousseau, Betty; Bradley, John E; Zhou, Fen; Mutneja, Stuti; Goepfert, Paul A; Boss, Jeremy M; Randall, Troy D; Sanz, Ignacio; Rosenberg, Alexander F; Lund, Frances E.

Immunity ; 56(4): 847-863.e8, 2023 04 11.

Artigo Inglês | MEDLINE | ID: mdl-36958335

20.

Can U Turn ILC2s Up?

Muller, Paul A; Mucida, Daniel.

Cell ; 171(4): 742-744, 2017 11 02.

Artigo Inglês | MEDLINE | ID: mdl-29100072

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Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation.

High-resolution analyses of associations between medications, microbiome, and mortality in cancer patients.

Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19.

An expanded universe of cancer targets.

Autism-related dietary preferences mediate autism-gut microbiome associations.

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption.

CTLA-4 tail fusion enhances CAR-T antitumor immunity.

A patient-centric modeling framework captures recovery from SARS-CoV-2 infection.

Adrenergic Signaling in Muscularis Macrophages Limits Infection-Induced Neuronal Loss.

Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma.

Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks.

A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9.

Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells.

Autism-related dietary preferences mediate autism-gut microbiome associations.

The CD8⁺ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects.

Bifunctional Immunity Proteins Protect Bacteria against FtsZ-Targeting ADP-Ribosylating Toxins.

Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development.

Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity.

A transcriptionally distinct subset of influenza-specific effector memory B cells predicts long-lived antibody responses to vaccination in humans.

Can U Turn ILC2s Up?