RESUMO
Garlic (Allium sativum L.) water- and ethanol-soluble extracts were prepared and purified by column chromatography. They were tested on garlic-sensitive patients and showed that the allergenic fraction was well located in a few column chromatography fractions. Guinea-pigs were sensitized with garlic water-soluble extracts and tested (open epicutaneous tests) with several fractions. The presence of diallyldisulfide was detected in the sensitizing chromatographic fractions. Guinea-pigs were successfully sensitized to this product and cross-reacted to garlic; animals sensitized to garlic extracts cross-reacted to diallyldisulfide. Both groups reacted to allicin, an oxidized derivative of diallyldisulfide present in garlic. Garlic-sensitive patients showed positive tests to diallyldisulfide, allylpropyldisulfide, allylmercaptan and allicin.
Assuntos
Alérgenos/análise , Compostos Alílicos , Dermatite de Contato/etiologia , Alho/toxicidade , Hipoglicemiantes/toxicidade , Extratos Vegetais/toxicidade , Plantas Medicinais , Animais , Dissulfetos/toxicidade , Alho/análise , Cobaias , Humanos , Testes do Emplastro , Extratos Vegetais/análise , Ácidos Sulfínicos/toxicidadeRESUMO
A capsule containing nickel sulphate (2,8 or 5,6 mg Ni) was given to 43 women with nickel contact allergy. They were all observed 24 hours later. In 9 patients no reaction was seen. Thirty-four had positive reactions: in 27 a flare up of previously affected areas of contact, in 8 patients pompholyx eczema type of the hands was observed, 23 complained of pruritus, secondary eruptions and in 4 even urticarial rush. Similar study was performed in a control group of 10 women, without any reactions. The authors compare the results of this study with others previously reported.
Assuntos
Níquel/imunologia , Administração Oral , Adolescente , Adulto , Desidratação/induzido quimicamente , Toxidermias/imunologia , Feminino , Humanos , Pessoa de Meia-Idade , Níquel/administração & dosagemRESUMO
31 patients allergic to Hirudoid cream were patch tested with the ingredients. 29 were allergic to the cream base and 16 to one or more components. The most common allergens were myristyl alcohol, cetostearyl alcohol and parabens. 14 patients reacted only to the base. The results are discussed.
Assuntos
Dermatite de Contato/etiologia , Toxidermias/etiologia , Heparinoides/efeitos adversos , Feminino , Géis , Humanos , Masculino , Testes do EmplastroRESUMO
9 patients with typical textile dermatitis were found to be allergic to dark polyester blouses. Thin-layer chromatography of the dyes extracted from the fabrics identified the presence of several dyes, from which Disperse Blue 106 was positive in all patients.
Assuntos
Compostos Azo/efeitos adversos , Corantes/efeitos adversos , Dermatite de Contato/etiologia , Adulto , Compostos Azo/isolamento & purificação , Corantes/isolamento & purificação , Dermatite de Contato/diagnóstico , Feminino , Humanos , Pessoa de Meia-Idade , Testes do Emplastro , TêxteisRESUMO
Eighty-four patients with severe psoriasis who required methotrexate (MTX) therapy have been reviewed. A total of 134 liver biopsies were performed. The lack of correlation between alcohol intake and the use of potential hepatotoxic drugs with pretreatment liver biopsies is noted. A review of 30 patients who had liver biopsies performed before and after MTX treatment showed no statistically significant difference between the histological grades before and after treatment. Nor was there any absolute correlation between the cumulative MTX doses and the histological changes of follow-up biopsies. In this group of patients, 15 (50%) developed fibrosis, which was severe in 2 patients, after 3,431 mg MTX average dose. Cirrhosis was observed in 3 patients (10%) after 1,667 mg MTX average dose. Follow-up liver biopsies are recommended for patients treated with MTX.
Assuntos
Doença Hepática Induzida por Substâncias e Drogas , Metotrexato/efeitos adversos , Psoríase/tratamento farmacológico , Adolescente , Adulto , Idoso , Criança , Feminino , Seguimentos , Humanos , Cirrose Hepática/induzido quimicamente , Hepatopatias/patologia , Masculino , Metotrexato/uso terapêutico , Pessoa de Meia-Idade , Psoríase/patologiaRESUMO
The authors report a study of allergic contact dermatitis in 329 Portuguese children of 14 years or younger. 170 children (64 male and 106 female) reacted to 1 or more allergens. Most of these were in the 11-14 years group. The main allergens were nickel, thimerosal, cobalt, mercury, fragrance-mix and potassium dichromate. Nickel reactivity predominated in females over the whole group, but a greater number of males younger than 5 years reacted to nickel. The number of positive reactions increased with age, but this was not accompained by an increase in the % of relevant tests. 12 children, all of them 13 or 14 years-old, had an occupational allergic contact dermatitis.
Assuntos
Dermatite de Contato/etiologia , Adolescente , Alérgenos/imunologia , Criança , Pré-Escolar , Dermatite de Contato/epidemiologia , Feminino , Humanos , Masculino , Portugal/epidemiologiaRESUMO
During 1995, we added gold sodium thiosulfate and potassium dicyanoaurate to the patch test standard series. Our purpose was to compare the reactivity of the gold salts, to determine the frequency of contact allergy to gold in our country, to compare our results with those of the Malmö group and, finally to try to clarify the clinical relevance 2853 patients were routinely tested and 168 patients answered a questionnaire similar to that used by the Malmö group. Contact allergy to gold was found in 23 patients, all women: 22 to gold sodium thiosulfate (0.78%), only 1 to potassium dicyanoaurate and 2 to both salts. All reactors had their ears pierced and were exposed to gold jewelery (mainly earrings). Simultaneous allergies to nickel and cobalt were statistically significant in patients with positive patch tests to gold sodium thiosulfate. Atopy was no more common among these patients.