Detalhe da pesquisa
1.
Rational design of a conformation-specific antibody for the quantification of Aß oligomers.
Proc Natl Acad Sci U S A
; 117(24): 13509-13518, 2020 06 16.
Artigo
Inglês
| MEDLINE | ID: mdl-32493749
2.
Systematic development of small molecules to inhibit specific microscopic steps of Aß42 aggregation in Alzheimer's disease.
Proc Natl Acad Sci U S A
; 114(2): E200-E208, 2017 01 10.
Artigo
Inglês
| MEDLINE | ID: mdl-28011763
3.
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.
Proc Natl Acad Sci U S A
; 114(6): E1009-E1017, 2017 02 07.
Artigo
Inglês
| MEDLINE | ID: mdl-28096355
4.
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-ß Aggregation.
ACS Chem Neurosci
; 14(4): 657-666, 2023 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36728544
5.
Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response.
Commun Biol
; 4(1): 843, 2021 07 07.
Artigo
Inglês
| MEDLINE | ID: mdl-34234268
6.
Exogenous misfolded protein oligomers can cross the intestinal barrier and cause a disease phenotype in C. elegans.
Sci Rep
; 11(1): 14391, 2021 07 13.
Artigo
Inglês
| MEDLINE | ID: mdl-34257326
7.
Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins.
Elife
; 102021 07 20.
Artigo
Inglês
| MEDLINE | ID: mdl-34292154
8.
Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer's Disease.
Pharmaceuticals (Basel)
; 14(12)2021 Dec 19.
Artigo
Inglês
| MEDLINE | ID: mdl-34959730
9.
A dopamine metabolite stabilizes neurotoxic amyloid-ß oligomers.
Commun Biol
; 4(1): 19, 2021 01 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33398040
10.
Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-ß and α-Synuclein and Suppress the Toxicity of Their Oligomers.
Front Neurosci
; 15: 680026, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34220435
11.
Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease.
Front Cell Dev Biol
; 9: 552549, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-33829010
12.
Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform.
Nat Protoc
; 15(6): 2071-2106, 2020 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32433626
13.
Small-molecule sequestration of amyloid-ß as a drug discovery strategy for Alzheimer's disease.
Sci Adv
; 6(45)2020 11.
Artigo
Inglês
| MEDLINE | ID: mdl-33148639
14.
A rationally designed bicyclic peptide remodels Aß42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer's disease.
Sci Rep
; 10(1): 15280, 2020 09 17.
Artigo
Inglês
| MEDLINE | ID: mdl-32943652
15.
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism.
Commun Biol
; 3(1): 435, 2020 08 13.
Artigo
Inglês
| MEDLINE | ID: mdl-32792544
16.
Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation.
Sci Adv
; 5(10): eaax5108, 2019 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31663025
17.
Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies.
ACS Chem Biol
; 14(6): 1352-1362, 2019 06 21.
Artigo
Inglês
| MEDLINE | ID: mdl-31050886
18.
Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans.
ACS Chem Biol
; 14(7): 1628-1636, 2019 07 19.
Artigo
Inglês
| MEDLINE | ID: mdl-31246415
19.
Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification.
ACS Cent Sci
; 5(8): 1417-1424, 2019 Aug 28.
Artigo
Inglês
| MEDLINE | ID: mdl-31482124
20.
C. elegans expressing D76N ß2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis.
Sci Rep
; 9(1): 19960, 2019 12 27.
Artigo
Inglês
| MEDLINE | ID: mdl-31882874