RESUMO
The effect of several dietary antioxidant supplements upon ultraviolet light-induced ornithine decarboxylase activity was determined. Hairless mice received diets supplemented with either butylated hydroxytoluene, disulfiram, phenobarbital, glutathione (reduced), or a special antioxidant mixture for 2 weeks before irradiation with FS-20 fluorescent sun lamps. Epidermal ornithine decarboxylase activity, the induction of which is thought to be a necessary component of skin tumor promotion, was determined at designated post-irradiation periods. Significant inhibition of ornithine decarboxylase induction was found in epidermis from animals receiving diets containing butylated hydroxytoluene, the antioxidant mixture, or disulfiram whereas no significant effects were noted in animals receiving reduced glutathione or phenobarbital. Butylated hydroxytoluene, at physiological concentrations, had no effect upon ornithine decarboxylase activity when added directly to the reaction mixture. Nor did this compound, when provided in the diet of animals, evoke a notable effect upon 12-0-tetra-decanoylphorbol-13-acetate induced ornithine decarboxylase. The latter finding suggests that dietary butylated hydroxytoluene inhibition of ultraviolet light-induced ornithine decarboxylase is a response related directly to the degree of irradation insult rather than a general effect upon the processes associated with carcinogenic promotion.
Assuntos
Antioxidantes/farmacologia , Carboxiliases/efeitos da radiação , Indução Enzimática/efeitos dos fármacos , Epiderme/enzimologia , Ornitina Descarboxilase/efeitos da radiação , Animais , Hidroxitolueno Butilado/farmacologia , Epiderme/efeitos dos fármacos , Epiderme/efeitos da radiação , Feminino , Camundongos , Camundongos Nus , Ornitina Descarboxilase/biossíntese , Raios UltravioletaRESUMO
The lesions of an unusual annular erythema in an infant evolved from erythematous papules, to rings, to interrupted arcs over 36 to 48 hours, and then resolved without a trace. New lesions appeared and evolved with remarkable uniformity for eight months and then disappeared. This seemingly unique eruption is compared with other annular erythemas described in infants.
Assuntos
Eritema/patologia , Eritema/classificação , Humanos , Lactente , Masculino , Remissão EspontâneaRESUMO
Subacute myelomonocytic leukemia is typically preceded by a preleukemic phase lasting 1 to 10 years. We describe a case of subacute myelomonocytic leukemia preceded by pruritus for 7 years and by the intermittent appearance of nonspecific necrotic dermal nodules for 4 years.