Detalhe da pesquisa
1.
A phase I study of pevonedistat, azacitidine, and venetoclax in patients with relapsed/refractory acute myeloid leukemia.
Haematologica
; 2024 Apr 04.
Artigo
Inglês
| MEDLINE | ID: mdl-38572562
2.
Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells.
Genes Dev
; 29(20): 2140-52, 2015 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26494789
3.
Reactivating latent HIV with PKC agonists induces resistance to apoptosis and is associated with phosphorylation and activation of BCL2.
PLoS Pathog
; 16(10): e1008906, 2020 10.
Artigo
Inglês
| MEDLINE | ID: mdl-33075109
4.
Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis.
Nucleic Acids Res
; 45(8): 4564-4576, 2017 05 05.
Artigo
Inglês
| MEDLINE | ID: mdl-28199696
5.
Correction: High cell surface death receptor expression determines type I versus type II signaling.
J Biol Chem
; 298(5): 101980, 2022 May.
Artigo
Inglês
| MEDLINE | ID: mdl-35490622
6.
4EBP1/c-MYC/PUMA and NF-κB/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells.
Blood
; 127(22): 2711-22, 2016 06 02.
Artigo
Inglês
| MEDLINE | ID: mdl-26917778
7.
Immunodetection of human topoisomerase I-DNA covalent complexes.
Nucleic Acids Res
; 44(6): 2816-26, 2016 Apr 07.
Artigo
Inglês
| MEDLINE | ID: mdl-26917015
8.
Synthesis of a peptide-universal nucleotide antigen: towards next-generation antibodies to detect topoisomerase I-DNA covalent complexes.
Org Biomol Chem
; 14(17): 4103-9, 2016 Apr 26.
Artigo
Inglês
| MEDLINE | ID: mdl-27113574
9.
Auxin-induced rapid degradation of inhibitor of caspase-activated DNase (ICAD) induces apoptotic DNA fragmentation, caspase activation, and cell death: a cell suicide module.
J Biol Chem
; 289(45): 31617-23, 2014 Nov 07.
Artigo
Inglês
| MEDLINE | ID: mdl-25248749
10.
Context-dependent antagonism between Akt inhibitors and topoisomerase poisons.
Mol Pharmacol
; 85(5): 723-34, 2014 May.
Artigo
Inglês
| MEDLINE | ID: mdl-24569089
11.
CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak.
J Biol Chem
; 288(32): 22899-914, 2013 Aug 09.
Artigo
Inglês
| MEDLINE | ID: mdl-23798675
12.
Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies.
Blood
; 119(2): 476-87, 2012 Jan 12.
Artigo
Inglês
| MEDLINE | ID: mdl-22080480
13.
CHK1 and WEE1 inhibition combine synergistically to enhance therapeutic efficacy in acute myeloid leukemia ex vivo.
Haematologica
; 99(4): 688-96, 2014 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-24179152
14.
Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells.
Haematologica
; 99(1): 60-9, 2014 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-23996484
15.
AMPK inhibition sensitizes acute leukemia cells to BH3 mimetic-induced cell death.
Cell Death Differ
; 31(4): 405-416, 2024 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-38538744
16.
Cytotoxicity of farnesyltransferase inhibitors in lymphoid cells mediated by MAPK pathway inhibition and Bim up-regulation.
Blood
; 118(18): 4872-81, 2011 Nov 03.
Artigo
Inglês
| MEDLINE | ID: mdl-21673341
17.
A BAK subdomain that binds mitochondrial lipids selectively and releases cytochrome C.
Cell Death Differ
; 30(3): 794-808, 2023 03.
Artigo
Inglês
| MEDLINE | ID: mdl-36376382
18.
A phase 2 and pharmacological study of sapanisertib in patients with relapsed and/or refractory acute lymphoblastic leukemia.
Cancer Med
; 12(23): 21229-21239, 2023 12.
Artigo
Inglês
| MEDLINE | ID: mdl-37960985
19.
Endoxifen downregulates AKT phosphorylation through protein kinase C beta 1 inhibition in ERα+ breast cancer.
NPJ Breast Cancer
; 9(1): 101, 2023 12 19.
Artigo
Inglês
| MEDLINE | ID: mdl-38114522
20.
High cell surface death receptor expression determines type I versus type II signaling.
J Biol Chem
; 286(41): 35823-35833, 2011 Oct 14.
Artigo
Inglês
| MEDLINE | ID: mdl-21865165