Detalhe da pesquisa
1.
Distinctive In Vitro Phenotypes in iPSC-Derived Neurons From Patients With Gain- and Loss-of-Function SCN2A Developmental and Epileptic Encephalopathy.
J Neurosci
; 44(8)2024 Feb 21.
Artigo
Inglês
| MEDLINE | ID: mdl-38148154
2.
Generation of a stably transfected mouse embryonic stem cell line for inducible differentiation to excitatory neurons.
Exp Cell Res
; 435(1): 113902, 2024 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-38145818
3.
Carbogen-Induced Respiratory Acidosis Blocks Experimental Seizures by a Direct and Specific Inhibition of NaV1.2 Channels in the Axon Initial Segment of Pyramidal Neurons.
J Neurosci
; 43(10): 1658-1667, 2023 03 08.
Artigo
Inglês
| MEDLINE | ID: mdl-36732074
4.
Variant-specific in vitro neuronal network phenotypes and drug sensitivity in SCN2A developmental and epileptic encephalopathy.
J Neurochem
; 2024 Mar 27.
Artigo
Inglês
| MEDLINE | ID: mdl-38544375
5.
The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm.
Proc Natl Acad Sci U S A
; 118(9)2021 03 02.
Artigo
Inglês
| MEDLINE | ID: mdl-33597309
6.
Cortical Tonic Inhibition Gates the Expression of Spike-and-Wave Discharges Associated with Absence Epilepsy.
J Integr Neurosci
; 23(1): 24, 2024 Jan 22.
Artigo
Inglês
| MEDLINE | ID: mdl-38287860
7.
Fundamental Neurochemistry Review: GABAA receptor neurotransmission and epilepsy: Principles, disease mechanisms and pharmacotherapy.
J Neurochem
; 165(1): 6-28, 2023 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36681890
8.
Biophysical characterization and modelling of SCN1A gain-of-function predicts interneuron hyperexcitability and a predisposition to network instability through homeostatic plasticity.
Neurobiol Dis
; 179: 106059, 2023 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36868483
9.
GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons.
Proc Natl Acad Sci U S A
; 117(6): 3192-3202, 2020 02 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31974304
10.
Therapeutic Inhibition of Acid-Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury.
Circulation
; 144(12): 947-960, 2021 09 21.
Artigo
Inglês
| MEDLINE | ID: mdl-34264749
11.
Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.
Neurobiol Dis
; 164: 105622, 2022 03.
Artigo
Inglês
| MEDLINE | ID: mdl-35031483
12.
Classification of antiseizure drugs in cultured neuronal networks using multielectrode arrays and unsupervised learning.
Epilepsia
; 63(7): 1693-1703, 2022 07.
Artigo
Inglês
| MEDLINE | ID: mdl-35460272
13.
State transitions through inhibitory interneurons in a cortical network model.
PLoS Comput Biol
; 17(10): e1009521, 2021 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34653178
14.
Cation leak underlies neuronal excitability in an HCN1 developmental and epileptic encephalopathy.
Brain
; 144(7): 2060-2073, 2021 08 17.
Artigo
Inglês
| MEDLINE | ID: mdl-33822003
15.
A P2RX7 single nucleotide polymorphism haplotype promotes exon 7 and 8 skipping and disrupts receptor function.
FASEB J
; 34(3): 3884-3901, 2020 03.
Artigo
Inglês
| MEDLINE | ID: mdl-32003498
16.
Protective effects of medium chain triglyceride diet in a mouse model of Dravet syndrome.
Epilepsia
; 62(12): 3131-3142, 2021 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34713469
17.
Posterior tibial nerve stimulation: is ultrasound guided needle placement more accurate?
Can J Urol
; 28(4): 10778-10782, 2021 08.
Artigo
Inglês
| MEDLINE | ID: mdl-34378515
18.
Dynamic action potential clamp predicts functional separation in mild familial and severe de novo forms of SCN2A epilepsy.
Proc Natl Acad Sci U S A
; 115(24): E5516-E5525, 2018 06 12.
Artigo
Inglês
| MEDLINE | ID: mdl-29844171
19.
Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death.
Proc Natl Acad Sci U S A
; 115(34): E8077-E8085, 2018 08 21.
Artigo
Inglês
| MEDLINE | ID: mdl-30076230
20.
Ion Channels in Genetic Epilepsy: From Genes and Mechanisms to Disease-Targeted Therapies.
Pharmacol Rev
; 70(1): 142-173, 2018 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29263209