Abnormalities in the distribution of serum immunoglobulin concentrations in juvenile rheumatoid arthritis.

Concentrations of serum IgG. IgA, and IgM were determined in 200 patients with juvenile rheumatoid arthritis. The relative frequency distribution of IgG and IgM approached that of a log-normal curve; however, there was marked skewing of the distribution of the serum concentrations of IgA. The prevalence of selective IgA deficiency was 4%. In order to permit further intragroup comparisons, the serum immunoglobulin concentrations were standardized by comparison to a sex-age matched control group. By this process it was found that there was concordance of the serum levels of IgG with IgA, and IgG with IgM. The standardized concentrations of IgA and IgM were less in females than males. The aberration in distribution of serum IgA concentrations found in this study, and the relative inability of females to respond to their disease by increasing specific serum immunoglobulin levels, add further data supporting the concept of immunodeficiency in the pathogenesis of juvenile rheumatoid arthritis.

The effects of stereotype activation on behavior: a review of possible mechanisms.

Considerable recent research has examined the effects that activated stereotypes have on behavior. Research on both self-stereotype activation and other-stereotype activation has tended to show that people behave in ways consistent with the stereotype (e.g., walking more slowly if the elderly stereotype is activated). Interestingly, however, the dominant account for the behavioral effects of self-stereotype activation involves a hot motivational factor (i.e., stereotype threat), whereas the dominant account for the behavioral effects of other-stereotype activation focuses on a rather cold cognitive explanation (i.e., ideomotor processes). The current review compares and contrasts the behavioral research on self- and other-stereotype activation and concludes that both motivational and cognitive explanations might account for effects in each domain.

Persistent antinuclear antibodies in children without identifiable inflammatory rheumatic or autoimmune disease.

One hundred eight children with musculoskeletal pain considered not to be due to an autoimmune or inflammatory disease had an antinuclear antibody (ANA) test performed. Twenty-four of these children were ANA positive on HEp-2 cell substrate at a screening serum dilution of 1:20. A positive ANA test persisted in 21 of 24 of the patients over a mean time period of 38 months (range 1 to 103 months). No sera from any patient at initial evaluation had anti-DNA antibodies by radioimmunoassay or by indirect immunofluorescence on Crithidia luciliae. One patient recently developed elevated anti-DNA (radioimmunoassay) antibodies but still has a negative assay on C luciliae. Four patients had antibodies to core histones by immunoblotting. None had antibodies to Sm, RNP, Ro (SS-A), or La (SS-B) by counterimmunoelectrophoresis. No patient developed an overt inflammatory or autoimmune disease during a mean follow-up period of 61 months (range 13 to 138 months). A child with musculoskeletal pain and a positive test for ANA, but with no clinical evidence at presentation of inflammatory or autoimmune disease, is at low risk of imminently developing such a disease.

The pulmonary manifestations of childhood onset systemic lupus erythematosus.

Pleuropulmonary disease in childhood onset SLE is common. It may be insidious or present as a life threatening event. North American Indian children in our population appear to be at high risk for severe lung disease. Pulmonary symptoms are present in the majority of children at some time during their disease course and pulmonary function studies are abnormal in the majority of patients. The pulmonary manifestations and frequency of occurrence in childhood appear to be similar to that described in adult onset SLE. Although pulmonary function studies do not correlate well with pulmonary symptoms, these studies provide objective quantification of the type and severity of the functional lesion. Serial tests may be helpful in monitoring disease activity in childhood SLE.

Current knowledge of the etiology and pathogenesis of chronic uveitis accompanying juvenile rheumatoid arthritis.

Inflammation of ocular and articular tissues occurs together with high frequency. In children with juvenile rheumatoid arthritis, uveitis not only is a frequent occurrence but constitutes the most serious complication of the most common type of chronic inflammatory arthritis of childhood.

Juvenile ankylosing spondylitis.

We are beginning to understand the clinical nature of JAS, its relationship with other SSA, and factors involved in its pathogenesis. Clinical data may now allow early recognition of JAS through the identification of children with the SEA syndrome or chronic arthritis associated with the HLA-B27. Comparative clinical studies of the prevalence of the disease and the role of immunogenetic, racial and environmental factors are needed. It may be necessary to review current criteria for the diagnosis of JRA and to develop similar criteria for the diagnosis of AS in childhood and adolescence.

Rubella virus and arthritis.

Rubella virus and the rubella virus vaccine are relatively common causes of acute arthralgias and occasionally objective arthritis. Rarely, chronic or relapsing joint syndromes may follow exposure to this virus or vaccine. This article will focus on the virus and its clinical illness. Major emphasis then will be given to the resulting arthritis syndromes and to consideration of the possible pathogenetic mechanisms of the joint manifestations.

Juvenile psoriatic arthritis, or juvenile arthritis with psoriasis?

Juvenile psoriatic arthritis (JPsA) has traditionally been considered to be one of the spondyloarthropathies. Clinical and laboratory evidence had shed doubt on the appropriateness of its inclusion in this classification, however. It is suggested that included under the rubric of JPsA there are two or more conditions: one in which arthritis and psoriasis occur coincidentally, and a second in which psoriasis occurs with a characteristic pattern of joint involvement: asymmetric oligoarthritis affecting large and small joints, with or without dactylitis, chronic uveitis, and antinuclear antibodies. Whether it is appropriate to consider JPsA as a variant of juvenile rheumatoid arthritis, or as an entirely separate disorder is uncertain.

Pneumococcal vertebral osteomyelitis presenting with an aseptic knee effusion in a child.

An 11 year-old girl developed a sterile knee effusion in association with vertebral osteomyelitis. Blood cultures grew Streptococcus Pneumoniae. Sterile joint effusions and vertebral osteomyelitis are both rare complications of pneumococcal infection although this organism is a frequent cause of bacteremia in childhood.

An unusual case of mixed sclerosing bone dystrophy presenting with morning stiffness and joint swelling in childhood: a case report.

We describe a case of a 16 year old native Indian girl with pain, morning stiffness and foot swelling who had radiographic changes consistent with mixed sclerosing bone dystrophy (MSBD) combined with fibrous dysplasia.

Maternal autoantibodies and fetal disease.

We have examined the relationships between maternal connective tissue disease (CTD), fetal and neonatal health, and the presence of specific autoantibodies: antinuclear antibodies (ANA), anti-Ro, antiLa, anti-Sm, anti-RNP, anti-DNA, and anticardiolipin (ACL) in 27 mothers with CTD (Group A), and 10 asymptomatic mothers of babies with complete congenital heart block (CCHB), or cardiac arrhythmias (Group B). Compared to 100 normal pregnant controls, autoantibodies were significantly more common in both Group A (96.3%, p less than 0.0005) and Group B (70%, p less than 0.0005), although the prevalence of autoantibodies in the Group A mothers having abnormal babies compared with those who had normal babies did not differ. Anti-La was present only in mothers with abnormal babies (7 of 17 compared to 0 of 10, p less than 0.025). Anti-La did not occur without anti-Ro, but anti-Ro occurred in 9 mothers without anti-La. Anti-Ro was present in the serum of all mothers of infants with CCHB and occurred alone in 3 of 4 instances. Titers of anti-Ro did not differ between abnormal and normal infants or their mothers. ACL occurred alone in the serum of 10 of 38 mothers, and was present in 7 mothers who had infants with cardiac abnormalities other than CCHB.

Mood management across affective states: the hedonic contingency hypothesis.

Mood management in positive and negative moods is relevant to a variety of social phenomena and has been especially important in the helping literature. Theorists have predicted that sad people strategically engage in mood management activities more than happy people. However, application of learning principles across affective states led the authors to hypothesize that hedonic rewards are more contingent on scrutiny of hedonic consequences in happy than sad states. Thus, happy people should scrutinize the hedonic consequences of potential behaviors more than sad people. A selective exposure paradigm was used to test this hedonic contingency hypothesis. People in whom happy, sad, or neutral states were induced were asked to choose activities in which to engage. In 3 experiments, happy people based their choices on the affective consequences of those activities more than sad or neutral individuals. Implications for interpreting past work are discussed.

Extending the bases of subjective attitudinal ambivalence: interpersonal and intrapersonal antecedents of evaluative tension.

Researchers have conceptualized ambivalence as resulting from the conflicting positive and negative thoughts and feelings that a person holds toward an attitude object (intrapersonal discrepancy). The authors investigated the hypothesis that perceived interpersonal attitudinal discrepancies can also contribute to feelings of subjective ambivalence beyond that determined by intrapersonal discrepancy. Study 1 revealed that the perception of attitudinal discrepancy with one's parents was associated with greater feelings of ambivalence. Studies 2 and 3 found increased ambivalence as a function of manipulated interpersonal discrepancies. Study 4 replicated and reversed the effect, revealing that interpersonal attitudinal discrepancy with a disliked other was associated with less ambivalence. Together, these studies provide support for the proposition that, because of balance processes, interpersonal relationships influence feelings of subjective ambivalence.

The gradual threshold model of ambivalence: relating the positive and negative bases of attitudes to subjective ambivalence.

This research examined the relationship between the measured (Study 1) and manipulated (Studies 2 and 3) positive and negative bases of attitudes and the psychological experience of attitudinal ambivalence. On the basis of these studies, the gradual threshold model of ambivalence (GTM) was advanced. The GTM holds that: (a) ambivalence increases in a negatively accelerating manner as the number of conflicting reactions (whichever of the positive or negative reactions are fewer in number) increases, (b) ambivalence is a negative function of the extent of dominant reactions, and (c) as the number of conflicting reactions increases, the impact of dominant reactions on ambivalence gradually decreases such that at some level of conflicting reactions (i.e, the threshold), the number of dominant reactions no longer has an impact on subjective ambivalence.

Flexible correction processes in social judgment: the role of naive theories in corrections for perceived bias.

Unlike many models of bias correction, our flexible correction model posits that corrections occur when judges are motivated and able to adjust assessments of targets according to their naive theories of how the context affects judgments of the target(s). In the current research, people flexibly correct assessments of different targets within the same context according to the differing theories associated with the context-target pairs. In Study 1, shared theories of assimilation and contrast bias are identified. Corrections consistent with those theories are obtained in Studies 2 and 3. Study 4 shows that idiographic measures of theories of bias predict the direction and magnitude of corrections. Implications of this work for corrections of attributions and bias removal in general are discussed.

Personality moderators of mood congruency effects on cognition: the role of self-esteem and negative mood regulation.

The authors report 3 experiments on negative mood regulation in which whether mood-congruency or mood-incongruency effects of negative mood on cognition were observed was dependent on an individual's self-esteem (SE). We found that most of our 224 participants tended toward mood-congruent recall under control conditions in which mood was relatively neutral. However, when a negative emotional state was induced, participants low in SE exhibited mood-congruent recall, but high-SE participants did not. In fact, the more negative high-SE participants felt, the more positive were their cognitions (mood-incongruent recall). This pattern was replicated in 3 experiments that included variations in the negative mood inductions and the type of information that was generated or retrieved. Our results suggest a strong link between SE and the regulation of negative emotional states.

Beyond valence in the perception of likelihood: the role of emotion specificity.

Positive and negative moods have been shown to increase likelihood estimates of future events matching these states in valence (e.g., E. J. Johnson & A. Tversky, 1983). In the present article, 4 studies provide evidence that this congruency bias (a) is not limited to valence but functions in an emotion-specific manner, (b) derives from the informational value of emotions, and (c) is not the inevitable outcome of likelihood assessment under heightened emotion. Specifically, Study 1 demonstrates that sadness and anger, 2 distinct, negative emotions, differentially bias likelihood estimates of sad and angering events. Studies 2 and 3 replicate this finding in addition to supporting an emotion-as-information (cf. N. Schwarz & G. L. Clore, 1983), as opposed to a memory-based, mediating process for the bias. Finally, Study 4 shows that when the source of the emotion is salient, a reversal of the bias can occur given greater cognitive effort aimed at accuracy.

Positive mood can increase or decrease message scrutiny: the hedonic contingency view of mood and message processing.

Currently dominant explanations of mood effects on persuasive message processing (i.e., cognitive capacity and feelings as information) predict that happy moods lead to less message scrutiny than neutral or sad moods. The hedonic contingency view (D. T. Wegener & R. E. Petty, 1994) predicts that happy moods can sometimes be associated with greater message processing activity because people in a happy mood are more attentive than neutral or sad people to the hedonic consequences of their actions. Consistent with this view, Experiment 1 finds that a happy mood can lead to greater message scrutiny than a neutral mood when the message is not mood threatening. Experiment 2 finds that a happy mood leads to greater message scrutiny than a sad mood when an uplifting message is encountered, but to less message scrutiny when a depressing message is encountered.

Individual differences in relative hemispheric alpha abundance and cognitive responses to persuasive communications.

Three experiments are reported investigating individual differences in interhemispheric electroencephalogram (EEG) activity and cognitive responses to persuasion. Experiment 1 indicated that subjects who were characterized by relative left hemispheric EEG activity over the parietal areas also produced a less affectively polarized profile of thought listings about the persuasive communication. Moreover, this individual difference emerged only when subjects were confronted by the forewarning and message; the basal patterns of interhemispheric EEG activity, which were obtained prior to the announcement of the attitudinal recommendation, did not portend distinguishable profiles of cognitive responding. Experiment 2 replicated the major findings of Experiment 1 using different topics and a within-subjects rather than a between-subjects design. Further analyses suggested that thinking about an attitude issue rather than responding to a persuasive communication was sufficient to obtain the above relationship between interhemispheric EEG alpha abundance and cognitive response. Experiment 3 used Tesser's time-to-think procedure to assess interhemispheric EEG patterning as a function of the affective polarization of topic-relevant thinking. The results supported the expectation that as subjects thought longer about attitude issues they exhibited a shifting of relative hemispheric EEG activity from the left toward the right parietal areas of the cerebral hemispheres. The significance and limitations of these findings for research on attitude change and the utility of including psychophysiological approaches to elusive research problems in personality and social psychology are discussed.

Stigmatized sources and persuasion: prejudice as a determinant of argument scrutiny.

Two experiments examined the viability of several explanations for why majority group individuals process persuasive messages from stigmatized sources more than those from nonstigmatized sources. In each study, majority group participants who either were high or low in prejudice or were high or low in ambivalence toward a stigmatized source's group were exposed to a persuasive communication attributed to a stigmatized (Black, Experiment 1; homosexual, Experiment 2) or nonstigmatized (White, Experiment 1; heterosexual, Experiment 2) source. In both studies, source stigmatization increased message scrutiny only among those who were low in prejudice toward the stigmatized group. This finding is most consistent with the view that people scrutinize messages from stigmatized sources in order to guard against possibly unfair reactions by themselves or others.