Detalhe da pesquisa
1.
Comparison of permitted daily exposure (PDE) values for active pharmaceutical ingredients (APIs) - Evidence of a robust approach.
Regul Toxicol Pharmacol
; 150: 105649, 2024 May 21.
Artigo
Inglês
| MEDLINE | ID: mdl-38782234
2.
Deriving harmonised permitted daily exposures (PDEs) for paracetamol (acetaminophen) CAS #: 103-90-2.
Regul Toxicol Pharmacol
; 115: 104692, 2020 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-32522580
3.
Use of the permitted daily exposure (PDE) concept for contaminants of intravitreal (IVT) drugs in multipurpose manufacturing facilities.
Regul Toxicol Pharmacol
; 101: 29-34, 2019 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-30367903
4.
Enhancing Mn(II)-Binding and Manganese Peroxidase Activity in a Designed Cytochrome c Peroxidase through Fine-Tuning Secondary-Sphere Interactions.
Biochemistry
; 55(10): 1494-502, 2016 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26885726
5.
A harmonization effort for acceptable daily exposure derivation - Considerations for application of adjustment factors.
Regul Toxicol Pharmacol
; 79 Suppl 1: S57-66, 2016 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-27221789
6.
Toxicokinetic and toxicodynamic considerations when deriving health-based exposure limits for pharmaceuticals.
Regul Toxicol Pharmacol
; 79 Suppl 1: S67-78, 2016 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-27224509
7.
Contribution of new technologies to characterization and prediction of adverse effects.
Crit Rev Toxicol
; 45(2): 172-83, 2015 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-25615431
8.
Identifying the elusive sites of tyrosyl radicals in cytochrome c peroxidase: implications for oxidation of substrates bound at a site remote from the heme.
Biochemistry
; 53(23): 3781-9, 2014 Jun 17.
Artigo
Inglês
| MEDLINE | ID: mdl-24901481
9.
EPITOME-2: An open-label study assessing the transition to a new formulation of intravenous epoprostenol in patients with pulmonary arterial hypertension.
Am Heart J
; 167(2): 210-7, 2014 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-24439982
10.
Bioavailability of therapeutic proteins by inhalation--worker safety aspects.
Ann Occup Hyg
; 58(7): 899-911, 2014 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-24958792
11.
Why Language Matters in Digital Endpoint Development: Harmonized Terminology as a Key Prerequisite for Evidence Generation.
Digit Biomark
; 8(1): 1-12, 2024.
Artigo
Inglês
| MEDLINE | ID: mdl-38222479
12.
Guidance on the establishment of acceptable daily exposure limits (ADE) to support Risk-Based Manufacture of Pharmaceutical Products.
Regul Toxicol Pharmacol
; 65(2): 242-50, 2013 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-23291300
13.
Assessing Daily Life Physical Activity by Actigraphy in Pulmonary Arterial Hypertension: Insights From the Randomized Controlled Study With Selexipag (TRACE).
Chest
; 163(2): 407-418, 2023 02.
Artigo
Inglês
| MEDLINE | ID: mdl-36089068
14.
Safety, Immunologic, and Clinical Activity of Durvalumab in Combination with Olaparib or Cediranib in Advanced Leiomyosarcoma: Results of the DAPPER Clinical Trial.
Clin Cancer Res
; 29(20): 4128-4138, 2023 Oct 13.
Artigo
Inglês
| MEDLINE | ID: mdl-37566240
15.
Increase in serum choline levels predicts for improved progression-free survival (PFS) in patients with advanced cancers receiving pembrolizumab.
J Immunother Cancer
; 10(6)2022 06.
Artigo
Inglês
| MEDLINE | ID: mdl-35705312
16.
Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1.
J Exp Med
; 201(6): 993-1005, 2005 Mar 21.
Artigo
Inglês
| MEDLINE | ID: mdl-15767369
17.
Effect of immunisation against angiotensin II with CYT006-AngQb on ambulatory blood pressure: a double-blind, randomised, placebo-controlled phase IIa study.
Lancet
; 371(9615): 821-7, 2008 Mar 08.
Artigo
Inglês
| MEDLINE | ID: mdl-18328929
18.
Environmental Risk Assessment for the Active Pharmaceutical Ingredient Mycophenolic Acid in European Surface Waters.
Environ Toxicol Chem
; 38(10): 2259-2278, 2019 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31225916
19.
Safety and tolerability of transition from inhaled treprostinil to oral selexipag in pulmonary arterial hypertension: Results from the TRANSIT-1 study.
J Heart Lung Transplant
; 38(1): 43-50, 2019 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30391194
20.
Preclinical evidence for nitrogen-containing bisphosphonate inhibition of farnesyl diphosphate (FPP) synthase in the kidney: implications for renal safety.
Toxicol In Vitro
; 22(4): 899-909, 2008 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-18325729