RESUMO
BACKGROUND: Oxidative stress and chronic inflammatory states triggered by a single-nucleotide polymorphism (SNP) in superoxide dismutase manganese-dependent gene (Val16Ala-SOD2) have been associated with the risk of developing several chronic, nontransmissible diseases. However, it is still not clear whether the VV-SOD2 genotype that causes higher basal superoxide anion levels has any impact on the risk for depression and self-reported psychological stress in elderly people. METHODS: In the present study, we tested this hypothesis using a case-control study where depression was detected using the Geriatric Depression Scale-15 (GDS-15). A total of 612 Brazilian free-living elderly subjects with a mean age of 67.1 ± 7.1 years old (number of controls, C = 497, and depressive individuals, D = 115) were included in this study. All participants had similar social, health, and lifestyle variables, with the exception of polypharmacy (≥5 medicines daily intake), which was higher in the D group, compared to C subjects. RESULTS: Our results showed that the VV-SOD2 genotype significantly increased the risk for depression and psychological stress in the elderly subjects, independently of sex/gender, age, and other prior diseases and health indicators (depression risk = 1.842, 1.109-3.061 95% CI, p = .018). VV-subjects also had a higher daily intake of antidepressants, anxiolytics, and anti-inflammatory drugs than A-allele subjects. CONCLUSION: Our findings support the hypothesis that genetically induced oxidative superoxide-hydrogen peroxide imbalance may be involved in an increased risk for developing depression and psychological stress in free-living elderly people without other chronic nontransmissible diseases.
Assuntos
Depressão/genética , Polimorfismo de Nucleotídeo Único , Estresse Psicológico/genética , Superóxido Dismutase/genética , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Vida Independente , Masculino , Pessoa de Meia-Idade , Mutação de Sentido Incorreto , Estresse Oxidativo , Superóxidos/metabolismoRESUMO
INTRODUCTION: Coronary artery bypass graft is often the treatment of choice for patients who suffer from unstable angina. We do not know whether this condition adds morbidity in this scenario. OBJECTIVE: To compare the outcomes of patients undergoing coronary artery bypass graft with unstable angina framework with patients who underwent coronary artery bypass graft showed no unstable angina. METHODS: Retrospective cohort study. Unstable angina was defined as acute coronary syndrome without ST elevation and without enzymatic alteration and/or class IV angina. RESULTS: Between February 1996 and July 2010, to 2,818 isolated coronary artery bypass graft performed, 1,016 (36.1%) patients had unstable angina. Multivariate analysis showed that patients with preoperative unstable angina used more medications such as acetylsalicylic acid, beta-blocker, heparin (anticoagulation), nitrate and less need for diuretics than patients without unstable angina. Patients with unstable angina used increased monitoring with Swan-Ganz and support with intra-aortic balloon than stable patients. On outcomes, required longer hospitalization (P=0.030) and had a lower death rate (P=0.018) in the post-coronary artery bypass graft alone. CONCLUSION: Submit patients to coronary artery bypass graft in the presence of acute coronary syndrome such as unstable angina did not increase the mortality rate.
Assuntos
Angina Instável/mortalidade , Ponte de Artéria Coronária/mortalidade , Idoso , Angina Instável/complicações , Feminino , Mortalidade Hospitalar , Humanos , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Período Perioperatório , Estudos Retrospectivos , Medição de Risco , Fatores de Risco , Fatores Sexuais , Resultado do TratamentoRESUMO
In Brazil, cervical uterine cancer is a major public health problem as it has high mortality rate indices among women of different ages. A cytopathological examination is recommended for preventing this type of cancer from the early stages of a woman's reproductive life. The scope of this study was both to give talks on sexual health education and establish the sexual health profile of women from St. Angelo/RS. The lectures included measures for prevention as well as identification of possible symptoms of the disease. The research into the sexual health profile of the participants was conducted by a structured questionnaire applied to 140 women aged between 15 and 60. It was found that even experiencing difficulties and apprehension, the majority of the women performed the preventive examination. The motivation for taking the exam is the appearance of symptoms and the habit of caring for their health. The participants mentioned the importance of health professionals and educators working together. The study sought to promote health and cancer prevention, seeking to avoid the disease and ensure better living conditions for women.
Assuntos
Educação em Saúde , Educação Sexual , Neoplasias do Colo do Útero/prevenção & controle , Adolescente , Adulto , Brasil , Feminino , Humanos , Pessoa de Meia-Idade , Adulto JovemRESUMO
INTRODUÇÃO: A cirurgia de revascularização do miocárdio muitas vezes é o tratamento de escolha de pacientes que sofrem angina instável. Não sabemos se essa condição acresce morbimortalidade nesse cenário. OBJETIVO: Comparar os desfechos dos pacientes submetidos a cirurgia de revascularização do miocárdio com quadro de angina instável com os pacientes submetidos a cirurgia de revascularização do miocárdio que não apresentaram angina instável. MÉTODOS: Coorte retrospectiva. A angina instável foi definida como síndrome coronariana aguda sem supradesnivelamento de ST e sem alteração enzimática e/ou angina classe IV. RESULTADOS: No período entre fevereiro de 1996 a julho de 2010, de 2.818 a cirurgia de revascularização do miocárdio isoladas realizadas, 1.016 (36,1%) pacientes apresentaram angina instável. A análise multivariada demonstrou que os pacientes com angina instável no pré-operatório utilizaram mais medicações como ácido acetilsalicílico, betabloqueador, heparina (anticoagulação plena), nitrato e menor necessidade de diureticoterapia, do que pacientes sem angina instável. Pacientes com angina instável utilizaram maior monitorização com Swan-Ganz e suporte com balão intra-aórtico do que os pacientes estáveis. Sobre os desfechos, necessitaram de maior tempo de internação (P=0,030) e apresentaram menor taxa de óbito (P=0,018) no pós-operatório de cirurgia de revascularização do miocárdio isolada. CONCLUSÃO: Submeter pacientes a cirurgia de revascularização do miocárdio isolada na vigência de síndrome coronariana aguda como angina instável não elevou a taxa de mortalidade.
INTRODUCTION: Coronary artery bypass graft is often the treatment of choice for patients who suffer from unstable angina. We do not know whether this condition adds morbidity in this scenario. OBJECTIVE: To compare the outcomes of patients undergoing coronary artery bypass graft with unstable angina framework with patients who underwent coronary artery bypass graft showed no unstable angina. METHODS: Retrospective cohort study. Unstable angina was defined as acute coronary syndrome without ST elevation and without enzymatic alteration and/or class IV angina. RESULTS: Between February 1996 and July 2010, to 2,818 isolated coronary artery bypass graft performed, 1,016 (36.1%) patients had unstable angina. Multivariate analysis showed that patients with preoperative unstable angina used more medications such as acetylsalicylic acid, beta-blocker, heparin (anticoagulation), nitrate and less need for diuretics than patients without unstable angina. Patients with unstable angina used increased monitoring with Swan-Ganz and support with intra-aortic balloon than stable patients. On outcomes, required longer hospitalization (P=0.030) and had a lower death rate (P=0.018) in the post-coronary artery bypass graft alone. CONCLUSION: Submit patients to coronary artery bypass graft in the presence of acute coronary syndrome such as unstable angina did not increase the mortality rate.
Assuntos
Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Angina Instável/mortalidade , Ponte de Artéria Coronária/mortalidade , Angina Instável/complicações , Mortalidade Hospitalar , Tempo de Internação , Análise Multivariada , Período Perioperatório , Estudos Retrospectivos , Medição de Risco , Fatores de Risco , Fatores Sexuais , Resultado do TratamentoRESUMO
No Brasil, o câncer cérvico-uterino constitui importante problema de saúde, pois apresenta alto índice de letalidade entre mulheres de varias idades. O exame citopatológico foi preconizado como medida de prevenção deste tipo de câncer, devendo ser realizado a partir do início da vida sexual. O estudo teve um caráter prático de promover educação em saúde sexual e conhecer o perfil da saúde sexual de mulheres de Santo Ângelo/RS. As palestras abordaram formas de prevenção e identificação de possíveis sintomas da doença. O levantamento do perfil de saúde sexual das participantes foi realizado através da aplicação de um questionário estruturado. Participaram das palestras 140 mulheres com idades entre 15 e 60 anos. Verificou-se que, mesmo enfrentando dificuldades e medo, a maioria delas realiza exame preventivo, motivada por aparecimento de sintomas e pelo hábito de cuidar da saúde. As participantes referiram a importância da integração entre profissionais e educadores em Saúde. O estudo foi direcionado no sentido de dar relevância à promoção da saúde e à prevenção do câncer, buscando evitar a doença e obter melhores condições de vida para as mulheres.
In Brazil, cervical uterine cancer is a major public health problem as it has high mortality rate indices among women of different ages. A cytopathological examination is recommended for preventing this type of cancer from the early stages of a woman's reproductive life. The scope of this study was both to give talks on sexual health education and establish the sexual health profile of women from St. Angelo/RS. The lectures included measures for prevention as well as identification of possible symptoms of the disease. The research into the sexual health profile of the participants was conducted by a structured questionnaire applied to 140 women aged between 15 and 60. It was found that even experiencing difficulties and apprehension, the majority of the women performed the preventive examination. The motivation for taking the exam is the appearance of symptoms and the habit of caring for their health. The participants mentioned the importance of health professionals and educators working together. The study sought to promote health and cancer prevention, seeking to avoid the disease and ensure better living conditions for women.