Increased resting heart rate and glucose metabolism in a community population.

OBJECTIVE: Resting heart rate (RHR) independently predicts cardiovascular death. Increased RHR is related to chronic diseases, but community-based studies are rare. We investigated this population and factors related to RHR. METHODS: In total, 374 participants underwent medical examinations from March 2019 to December 2019. Participants were divided into groups with low RHR (LRHR; <65 beats/minute) and high RHR (HRHR; ≥65 beats/minute). RHR was judged using resting electrocardiogram at physical examination. We conducted laboratory examinations, including glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG), and blood lipids, among participants with chronic diseases. We used Cox proportional risk regression and multivariate analyses for the following covariates: previous chronic diseases, body mass index (BMI), smoking, blood lipids, and FPG. RESULTS: The incidence of type 2 diabetes mellitus (T2DM) and HbA1c values were both significantly higher in the HRHR group than in the LRHR group. Spearman correlation analysis showed RHR had a positive correlation with low-density lipoprotein, BMI, FPG, and HbA1c (r = 0.104574, 0.117266, 0.116041, and 0.311761, respectively). Multiple linear regression analysis showed age, hypertension, T2DM, and HbA1c were factors influencing RHR. CONCLUSION: RHR showed strong correlation with T2DM and HbA1c in our community population, suggesting that RHR may be a risk factor for cardiovascular disease.

Analysis in saliva microbiome composition in patients with NAFLD and normal subjects / 实用医学杂志

Objective To analyze the diversity of salivary bacteria in patients with nonalcoholic fatty liv-er disease(NAFLD group)and healthy control group(HC group). Methods Saliva samples were collected from 24 patients with nonalcoholic fatty liver disease and 22 healthy control.Genomic DNA of the samples was extracted and extended to 16S rRNA V4-V5 hypervariable region after PCR with Illumina high-throughput sequencing tech-nology.All the data,including operational taxonomic units,diversity indexes and species annotation,etc.was ana-lyzed. Results 39118 optimized sequences in the saliva of each group were obtained,including nonalcoholic fatty liver group clustering OTUs about 308 ± 48 and healthy control group clustering OTUs about 305 ± 53.The diversi-ty analysis of NAFLD group and HC group showed that there was little difference in diversity of the whole salivary bacteria.The data of the species analysis of the saliva bacteria in two group indicate that the composition was simi-lar and the relative abundance was different in phylum and genus.In NAFLD group,the ratio of the abundance of firmicutes(20.42%)increased and the proportion of bacteroides(36.75%)decreased in phylum. Genus of the NAFLD group,the ratio of fusobacterium,porphyromonas and veillonella increased significantly,and the ratio of prevotella and[Prevotella]decreased.Conclusion In the NAFLD group,the abundance of firmicutes increased, and the abundance of the bacteria decreased.It was speculated that the imbalance of the salivary bacteria is associ-ated with nonalcoholic fatty liver disease.