Detalhe da pesquisa
1.
Predicting multiple conformations via sequence clustering and AlphaFold2.
Nature
; 625(7996): 832-839, 2024 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-37956700
2.
From primordial clocks to circadian oscillators.
Nature
; 616(7955): 183-189, 2023 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36949197
3.
Cumulative mechanism of several major imatinib-resistant mutations in Abl kinase.
Proc Natl Acad Sci U S A
; 117(32): 19221-19227, 2020 08 11.
Artigo
Inglês
| MEDLINE | ID: mdl-32719139
4.
Tuning of pKa values activates substrates in flavin-dependent aromatic hydroxylases.
J Biol Chem
; 295(12): 3965-3981, 2020 03 20.
Artigo
Inglês
| MEDLINE | ID: mdl-32014994
5.
Informing Efforts to Develop Nitroreductase for Amine Production.
Molecules
; 23(2)2018 Jan 24.
Artigo
Inglês
| MEDLINE | ID: mdl-29364838
6.
Understanding the broad substrate repertoire of nitroreductase based on its kinetic mechanism.
J Biol Chem
; 289(22): 15203-14, 2014 May 30.
Artigo
Inglês
| MEDLINE | ID: mdl-24706760
7.
The conformational landscape of fold-switcher KaiB is tuned to the circadian rhythm timescale.
bioRxiv
; 2024 Jun 03.
Artigo
Inglês
| MEDLINE | ID: mdl-38895306
8.
The transfer of reduced flavin mononucleotide from LuxG oxidoreductase to luciferase occurs via free diffusion.
Biochemistry
; 52(39): 6834-43, 2013 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24004065
9.
A conserved active-site threonine is important for both sugar and flavin oxidations of pyranose 2-oxidase.
J Biol Chem
; 285(13): 9697-9705, 2010 Mar 26.
Artigo
Inglês
| MEDLINE | ID: mdl-20089849
10.
Ancient origins of allosteric activation in a Ser-Thr kinase.
Science
; 367(6480): 912-917, 2020 02 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32079772
11.
How directed evolution reshapes the energy landscape in an enzyme to boost catalysis.
Science
; 370(6523): 1442-1446, 2020 12 18.
Artigo
Inglês
| MEDLINE | ID: mdl-33214289
12.
Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2.
Nat Commun
; 9(1): 4507, 2018 10 30.
Artigo
Inglês
| MEDLINE | ID: mdl-30375376
13.
Dynamics of human protein kinase Aurora A linked to drug selectivity.
Elife
; 72018 06 14.
Artigo
Inglês
| MEDLINE | ID: mdl-29901437
14.
Mechanism-Informed Refinement Reveals Altered Substrate-Binding Mode for Catalytically Competent Nitroreductase.
Structure
; 25(7): 978-987.e4, 2017 07 05.
Artigo
Inglês
| MEDLINE | ID: mdl-28578873
15.
H-bonding and positive charge at the N5/O4 locus are critical for covalent flavin attachment in trametes pyranose 2-oxidase.
J Mol Biol
; 402(3): 578-94, 2010 Sep 24.
Artigo
Inglês
| MEDLINE | ID: mdl-20708626