Detalhe da pesquisa
1.
Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease.
J Neurochem
; 124(6): 880-93, 2013 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-23121022
2.
The long lifespan of two bat species is correlated with resistance to protein oxidation and enhanced protein homeostasis.
FASEB J
; 23(7): 2317-26, 2009 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-19244163
3.
Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer's disease.
Exp Neurol
; 239: 28-37, 2013 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-23022919
4.
Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice.
J Cereb Blood Flow Metab
; 33(10): 1605-11, 2013 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-23838831
5.
Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production?
J Gerontol A Biol Sci Med Sci
; 67(8): 841-52, 2012 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-22219516
6.
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease.
PLoS One
; 5(4): e9979, 2010 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20376313
7.
Testing hypotheses of aging in long-lived mice of the genus Peromyscus: association between longevity and mitochondrial stress resistance, ROS detoxification pathways, and DNA repair efficiency.
Age (Dordr)
; 30(2-3): 121-33, 2008 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-19424862