Detalhe da pesquisa
1.
Prediction of inotropic effect based on calcium transients in human iPSC-derived cardiomyocytes and machine learning.
Toxicol Appl Pharmacol
; 459: 116342, 2023 01 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36502871
2.
Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery.
Annu Rev Pharmacol Toxicol
; 58: 65-82, 2018 01 06.
Artigo
Inglês
| MEDLINE | ID: mdl-29029591
3.
Evolving Cardiac Safety in Drug Discovery: Time for Immunology Integration.
Circulation
; 149(22): 1704-1707, 2024 May 28.
Artigo
Inglês
| MEDLINE | ID: mdl-38805578
4.
Cytochrome P450 2J2: Potential Role in Drug Metabolism and Cardiotoxicity.
Drug Metab Dispos
; 46(8): 1053-1065, 2018 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29695613
5.
Information-Derived Mechanistic Hypotheses for Structural Cardiotoxicity.
Chem Res Toxicol
; 31(11): 1119-1127, 2018 11 19.
Artigo
Inglês
| MEDLINE | ID: mdl-30350600
6.
Application of microphysiological systems for nonclinical evaluation of cell therapies.
ALTEX
; 2024 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38746991
7.
Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes.
Cell Stem Cell
; 31(3): 292-311, 2024 03 07.
Artigo
Inglês
| MEDLINE | ID: mdl-38366587
8.
Preservation of cardiomyocytes from the adult heart.
J Mol Cell Cardiol
; 64: 108-19, 2013 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-24051370
9.
Simultaneously discovering the fate and biochemical effects of pharmaceuticals through untargeted metabolomics.
Nat Commun
; 14(1): 4653, 2023 08 03.
Artigo
Inglês
| MEDLINE | ID: mdl-37537184
10.
Deriving waveform parameters from calcium transients in human iPSC-derived cardiomyocytes to predict cardiac activity with machine learning.
Stem Cell Reports
; 17(3): 556-568, 2022 03 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35148844
11.
Intra- and intercellular signaling pathways associated with drug-induced cardiac pathophysiology.
Trends Pharmacol Sci
; 42(8): 675-687, 2021 08.
Artigo
Inglês
| MEDLINE | ID: mdl-34092416
12.
An Extensive Metabolomics Workflow to Discover Cardiotoxin-Induced Molecular Perturbations in Microtissues.
Metabolites
; 11(9)2021 Sep 21.
Artigo
Inglês
| MEDLINE | ID: mdl-34564460
13.
Cardiovascular microphysiological systems (CVMPS) for safety studies - a pharma perspective.
Lab Chip
; 21(3): 458-472, 2021 02 09.
Artigo
Inglês
| MEDLINE | ID: mdl-33471007
14.
In silico approaches in organ toxicity hazard assessment: Current status and future needs for predicting heart, kidney and lung toxicities.
Comput Toxicol
; 202021 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-35721273
15.
Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective.
Clin Pharmacol Ther
; 109(2): 310-318, 2021 02.
Artigo
Inglês
| MEDLINE | ID: mdl-32866317
16.
A pharmacological characterization of electrocardiogram PR and QRS intervals in conscious telemetered rats.
J Pharmacol Toxicol Methods
; 102: 106679, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-32014539
17.
Current and future approaches to nonclinical cardiovascular safety assessment.
Drug Discov Today
; 25(7): 1129-1134, 2020 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32209428
18.
Drug-induced myocardial dysfunction - recommendations for assessment in clinical and pre-clinical studies.
Expert Opin Drug Saf
; 19(3): 281-294, 2020 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-32064957
19.
Pivotal role for two electron reduction in 2,3-dimethoxy-1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone metabolism and kinetics in vivo that prevents liver redox stress.
Chem Res Toxicol
; 22(4): 717-25, 2009 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-19338340
20.
Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency.
PLoS One
; 14(3): e0214545, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-30925190