Detalhe da pesquisa
1.
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity.
Bioorg Med Chem
; 21(13): 3695-701, 2013 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23680444
2.
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212.
Antimicrob Agents Chemother
; 56(1): 324-31, 2012 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-22024828
3.
Identification of a novel pyrrole derivative endowed with antimycobacterial activity and protection index comparable to that of the current antitubercular drugs streptomycin and rifampin.
Bioorg Med Chem
; 18(22): 8076-84, 2010 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20934344
4.
1,5-Diphenylpyrrole derivatives as antimycobacterial agents. Probing the influence on antimycobacterial activity of lipophilic substituents at the phenyl rings.
J Med Chem
; 51(12): 3644-8, 2008 Jun 26.
Artigo
Inglês
| MEDLINE | ID: mdl-18494459
5.
HPLC enantioseparation and absolute configuration of novel anti-inflammatory pyrrole derivatives.
Chirality
; 20(6): 775-80, 2008 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-18200590
6.
Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity.
J Med Chem
; 50(22): 5403-11, 2007 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17915854
7.
Antimycobacterial agents. Novel diarylpyrrole derivatives of BM212 endowed with high activity toward Mycobacterium tuberculosis and low cytotoxicity.
J Med Chem
; 49(16): 4946-52, 2006 Aug 10.
Artigo
Inglês
| MEDLINE | ID: mdl-16884306
8.
1,5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors.
J Med Chem
; 48(9): 3428-32, 2005 May 05.
Artigo
Inglês
| MEDLINE | ID: mdl-15857149
9.
Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography.
ChemMedChem
; 8(7): 1175-83, 2013 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-23733388
10.
Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection.
PLoS One
; 8(2): e56980, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23437287
11.
Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme.
Eur J Med Chem
; 58: 287-98, 2012 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-23131542
12.
Developing pyrrole-derived antimycobacterial agents: a rational lead optimization approach.
ChemMedChem
; 6(4): 593-9, 2011 Apr 04.
Artigo
Inglês
| MEDLINE | ID: mdl-21341373
13.
Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties.
J Med Chem
; 54(22): 7759-71, 2011 Nov 24.
Artigo
Inglês
| MEDLINE | ID: mdl-21992176
14.
Antimycobacterial compounds. Optimization of the BM 212 structure, the lead compound for a new pyrrole derivative class.
Bioorg Med Chem
; 13(4): 1221-30, 2005 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-15670931
15.
Antimycobacterial compounds. New pyrrole derivatives of BM212.
Bioorg Med Chem
; 12(6): 1453-8, 2004 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-15018918