Detalhe da pesquisa
1.
A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3' End Processing Complex.
Mol Cell
; 77(6): 1206-1221.e7, 2020 03 19.
Artigo
Inglês
| MEDLINE | ID: mdl-31980388
2.
Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance.
Mol Cell
; 79(4): 645-659.e9, 2020 08 20.
Artigo
Inglês
| MEDLINE | ID: mdl-32692974
3.
Base editing of haematopoietic stem cells rescues sickle cell disease in mice.
Nature
; 595(7866): 295-302, 2021 07.
Artigo
Inglês
| MEDLINE | ID: mdl-34079130
4.
The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development.
J Biol Chem
; 295(24): 8325-8330, 2020 06 12.
Artigo
Inglês
| MEDLINE | ID: mdl-32350114
5.
PAX3-FOXO1 dictates myogenic reprogramming and rhabdomyosarcoma identity in endothelial progenitors.
Nat Commun
; 14(1): 7291, 2023 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37968277
6.
Potent and uniform fetal hemoglobin induction via base editing.
Nat Genet
; 55(7): 1210-1220, 2023 07.
Artigo
Inglês
| MEDLINE | ID: mdl-37400614
7.
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells.
bioRxiv
; 2023 May 27.
Artigo
Inglês
| MEDLINE | ID: mdl-37292647
8.
Attenuation of zinc finger nuclease toxicity by small-molecule regulation of protein levels.
PLoS Genet
; 5(2): e1000376, 2009 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-19214211
9.
SJPYT-195: A Designed Nuclear Receptor Degrader That Functions as a Molecular Glue Degrader of GSPT1.
ACS Med Chem Lett
; 13(8): 1311-1320, 2022 Aug 11.
Artigo
Inglês
| MEDLINE | ID: mdl-35978691
10.
CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk.
Nat Genet
; 54(5): 637-648, 2022 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35513723
11.
Antitumor Effects of CAR T Cells Redirected to the EDB Splice Variant of Fibronectin.
Cancer Immunol Res
; 9(3): 279-290, 2021 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33355188
12.
Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin.
Nat Genet
; 53(8): 1177-1186, 2021 08.
Artigo
Inglês
| MEDLINE | ID: mdl-34341563
13.
Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL).
Sci Rep
; 11(1): 5154, 2021 03 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33664368
14.
SLFN11 is Widely Expressed in Pediatric Sarcoma and Induces Variable Sensitization to Replicative Stress Caused By DNA-Damaging Agents.
Mol Cancer Ther
; 20(11): 2151-2165, 2021 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34413129
15.
Therapeutic gene editing strategies using CRISPR-Cas9 for the ß-hemoglobinopathies.
J Biomed Res
; 35(2): 115-134, 2020 Nov 09.
Artigo
Inglês
| MEDLINE | ID: mdl-33349624
16.
Single-Cell Analysis of Neonatal HSC Ontogeny Reveals Gradual and Uncoordinated Transcriptional Reprogramming that Begins before Birth.
Cell Stem Cell
; 27(5): 732-747.e7, 2020 11 05.
Artigo
Inglês
| MEDLINE | ID: mdl-32822583
17.
BCL11A enhancer-edited hematopoietic stem cells persist in rhesus monkeys without toxicity.
J Clin Invest
; 130(12): 6677-6687, 2020 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32897878
18.
A Practical Guide to Genome Editing Using Targeted Nuclease Technologies.
Compr Physiol
; 9(2): 665-714, 2019 03 14.
Artigo
Inglês
| MEDLINE | ID: mdl-30873595
19.
The efficiency of murine MLL-ENL-driven leukemia initiation changes with age and peaks during neonatal development.
Blood Adv
; 3(15): 2388-2399, 2019 08 13.
Artigo
Inglês
| MEDLINE | ID: mdl-31405949
20.
Genome editing of HBG1 and HBG2 to induce fetal hemoglobin.
Blood Adv
; 3(21): 3379-3392, 2019 11 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31698466