1.
Clin Infect Dis
; 53(12): 1291-5, 2011 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22028438
RESUMO
The role of rs1127354/rs7270101 alleles at the inosine triphosphatase (ITPA) gene on ribavirin-induced anemia was assessed in 74 patients with hepatitis C virus and human immunodeficiency virus coinfection. Anemia developed in 80% of patients with normal ITPA activity compared with 33% of those with reduced ITPA activity. In contrast, ITPA variants did not influence sustained virological response.