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Indoor Air ; 27(5): 933-945, 2017 09.
Artigo em Inglês | MEDLINE | ID: mdl-28370571

RESUMO

Most studies on molds focus on Alternaria alternata and Aspergillus fumigatus. Here, we report on inflammatory and allergenic properties of more typical indoor species Aspergillus versicolor, P. chrysogenum, C. cladosporioïdes, and C. sphaerospermum that were compared to A. alternata and A. fumigatus. In a mouse model, after intranasal instillation, A. alternaria, A. versicolor, and C. sphaerospermum induced the early recruitment of neutrophils and the strong expression of inflammatory markers in the bronchoalveolar lavages fluids. A. fumigatus also induced the early accumulation of neutrophils but with lower levels of inflammatory markers. Chronic treatment induced variable response according to species: P. chrysogenum and A. fumigatus appeared strong pro-allergenic inducers compared to A. alternata and C. sphaerospermum while A. versicolor and C. cladosporioides induced a mixed pro-allergenic/pro-inflammatory response. In mold-sensitized asthmatics, mold-specific Immunoglobulin E (IgE) were detected with an in-house dot-blot assay. A. fumigatus and A. alternata were the most frequent sensitizers. Altogether, P. chrysogenum, P. brevicompactum, C. sphaerospermum, and C. cladosporïoides were the "major sensitizer" (defined as the strongest response against a single mold species) for almost 30% of the asthmatics. These results show that, not only A. alternata and A. fumigatus, but also indoor species have strong inflammatory and allergic properties and a harmful potency.


Assuntos
Microbiologia do Ar , Asma/imunologia , Hipersensibilidade/imunologia , Inflamação/imunologia , Poluição do Ar em Ambientes Fechados , Alternaria/isolamento & purificação , Animais , Aspergillus/isolamento & purificação , Líquido da Lavagem Broncoalveolar , Cladosporium/isolamento & purificação , Citocinas/imunologia , Feminino , Humanos , Imunoglobulina E/sangue , Pulmão/patologia , Camundongos , Camundongos Endogâmicos C57BL , Penicillium/isolamento & purificação
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