Preoperative vascular mapping with multislice CT of deep inferior epigastric artery perforators in planning breast reconstruction after mastectomy.

PURPOSE: Our aim was to evaluate the usefulness of computed tomography angiography (CTA) in vascular mapping for planning breast reconstruction after mastectomy using a free flap made with the deep inferior epigastric perforators (DIEP). MATERIALS AND METHODS: We retrospectively evaluated 41 patients, mean age 57 years, scheduled for mastectomy. CTA was performed with a 64-row scanner (Aquilion 64, Toshiba Medical Systems, Japan), with injection of 100 ml of contrast medium (iomeprol 350 mgI/ml, Bracco, Italy) at 4.5 ml/s. Maximum intensity projection (MIP) and three-dimensional volume-rendering (VR) reconstructions were made to mark perforator positions. Presentation frequency, anatomy and artery opacification quality were evaluated. RESULTS: DIEP were always depicted (n=81) and subdivided according to Taylor's classification into type I (65%), type II (28%), and type III (7%). We observed a mean of three (range, 1-5) DIEP arteries on the right and two (range, 1-5) on the left side. The superficial inferior epigastric artery (SIEA) was depicted in 6/41 patients, bilaterally in three cases. Opacification was optimal in 30/41 cases, venous contamination due to late arterial phase in eight and low opacification due to early scan in three. CONCLUSIONS: Studying DIEP with CTA is useful in the surgical planning of breast reconstruction, even though it requires careful optimisation owing to the critical timing of opacification typical of that vascular district.

Multimodal approach to the endovascular treatment of embolisation or exclusion of the renal arteries and their distal and/or polar branches: personal experience.

PURPOSE: This study reviews our experience over the last 10 years with procedures of embolisation and/or exclusion of the renal arteries, their parenchymal branches and the polar arteries [renal artery embolisation (RAE)]. MATERIALS AND METHODS: Twenty-seven patients (19 men and eight women; age range 37-93 years; mean 74 years) underwent RAE. The indications were: symptomatic gross haematuria in nine patients (33.3%) (tumour-related in seven and iatrogenic in two), symptomatic inoperable renal tumour in five (18.5%), large subcapsular or perirenal haematoma in three (11.1%) and aneurysm of the main renal artery in two (7.4%). Eight patients (29.6%) scheduled for endovascular aneurysm repair (EVAR) of the abdominal aorta underwent prophylactic embolisation of the renal polar branch arising from the aneurysmal sac or the subrenal aortic neck to prevent the possible revascularisation of the sac. Different embolisation agents were used: coils (17 cases), embolisation particles (14 cases), glue (one case), coated stent (two cases) and mechanical occlusion devices (two cases). In 11 cases, two to three different embolisation agents were used together. RESULTS: Technical success was achieved in 26/27 patients (96.3%); in one case, embolisation of a polar artery arising from the aneurysmal sac was not possible. One case of gross haematuria recurred 13 months after the procedure and was re-treated with success. There were no cases of major or minor complications. CONCLUSIONS: RAE is an effective and minimally invasive procedure in the treatment of neoplastic/iatrogenic symptomatic gross haematuria and in the palliative treatment of inoperable renal tumours. One possible new indication is the prophylactic exclusion of the polar artery arising from the neck or the sac of an abdominal aortic aneurysm in patients who are candidates for EVAR. In our experience, we observed very low morbidity and a short hospital stay. This procedure requires the availability of various materials for performing embolisation and experience in their use.

Prevalence of extravascular collateral findings during 64-slice CT angiography of the abdominal aorta and lower limbs.

PURPOSE: The aim of this study was to assess the prevalence of extravascular collateral findings during 64-slice CT angiography of the abdominal aorta (AA-CTA) and lower limbs (LL-CTA). MATERIALS AND METHODS: The images of 536 AA-CTA and LL-CTA examinations performed for suspected aortic and peripheral vascular disease in 500 patients were retrospectively reviewed. Two radiologists evaluated the 5-mm axial images independently using appropriate window settings for the area under investigation. Collateral findings were divided according to their clinical significance into significant, nonsignificant and meriting further investigation. RESULTS: No collateral findings were identified in 97/500 patients (19.4%). In the remaining patients, 821 collateral findings were detected, of which 43 (5.24%) were classified as significant, 135 (16.44%) as meriting further investigation and 643 (78.32%) as nonsignificant. The findings indicative of the presence of a malignant lesion totalled 36 (4.5%). CONCLUSIONS: AA-CTA and LL-CTA demonstrate a nonnegligible prevalence of collateral findings, many of them major. It therefore appears that the evaluation should focus not only on the image reconstructions to identify vascular disease, but also on the native axial images to detect incidental findings.

Comparison between 64-row CT angiography and digital subtraction angiography in the study of lower extremities: personal experience.

PURPOSE: This study was undertaken to evaluate the potential of 64-row multislice computed tomography (CT) versus digital subtraction angiography (DSA) in detecting significant lesions of lower-extremity inflow and runoff arteries. MATERIALS AND METHODS: Fifty-three patients underwent 64-row multislice CT and DSA over a mean of 36 days. The vascular tree was divided into 33 segments. Three readers independently reviewed the axial CT scans and multiplanar oblique and two- and three-dimensional reconstructions (maximum intensity projection and volume rendering) images to assess degree of stenosis according to four categories: 1 (0%-49% stenosis); 2 (50%-99% stenosis); 3 (occluded); 4 (not evaluable). In all cases, DSA was performed by arterial catheterisation. RESULTS: In 53 patients, 1,440 segments were evaluated (infrarenal aorta and 16 arterial segments for each leg; 42 bilateral studies, 11 unilateral studies). Compared with DSA, CT angiography yielded 97.2% sensitivity, 97% specificity, 92.5% positive predictive value, 98.9% negative predictive value, 97.1% diagnostic accuracy and 95.4% concordance on the degree of stenosis. CONCLUSIONS: Sixty-four-row multislice CT proved to be helpful in detecting haemodynamically significant lesions in peripheral arterial occlusive disease and improved the results obtained with 4- and 16-slice multidetector CT. In addition, owing to the high spatial resolution and rigorous technique, no variations in the data obtained below the knee were detected, overcoming a limitation of earlier generations of CT scanners.

Systemic and regional haemodynamic effects of aortofemoral angiography.

UNLABELLED: The aim was to investigate the regional and systemic haemodynamic consequences of bolus injection of fluids with different physical properties in the course of routine aortography. Iopamidol was compared with an equiosmolar solution of mannitol and with a 0.9 N saline solution. Continuous blood flow and Pulsatility Index (PI), as an index of regional vascular resistance, were measured by Doppler technique. Finger arterial pressure and heart rate were monitored at the time and for 3 min following each intraaortic bolus injections. The patients who underwent routine aortography were grouped according to the site of the flow measurements: common femoral artery, common carotid artery and brachial artery. Flow changes induced by the bolus infusion were evident for all the fluids but only at the femoral artery level. After an immediate (3 +/- 2 s) and brief (2 +/- 2 s) but marked reduction of flow and in-phase increase of PI following the bolus, further haemodynamic changes were observed only in the femoral artery, with a peak at 35 +/- 10 s and returning to baseline values after 70 +/- 15 s, in terms of both increased mean blood velocity and decreased PI. Saline and mannitol induced overall blood velocity alterations of 54% and 80%, respectively, and PI reductions of 44% and 57% compared with those induced by iopamidol. In the other vascular areas there was only a 17 +/- 2% increase of the physiological early diastolic backflow at the brachial artery level. Blood pressure decreased and heart rate increased in phase with the flow changes of the femoral artery. IN CONCLUSION: (1) a dramatic rheodynamic perturbation at the site of injection induces a vasodilating stimulus; (2) the haemodynamic response following injection results in marked vasodilation of only the tributary vascular bed; (3) flow steal may occur from other beds towards the lower limb vascular beds owing to vascular impedance imbalance; (4) a reduction of systemic arterial pressure is induced in phase with the regional vascular events and a reflex increase of the heart rate; and (5) the physical properties of the injected fluids influence the intensity of the perturbation, although the decisive triggering factor is the counterflowing bolus per se.

Computed tomographic follow-up in a case of Addison's disease.

Addison's disease of the adrenal glands presents with different pathological findings depending on the stage. In the acute phase the adrenal glands are bilaterally enlarged while in the chronic phase the glands are small and calcified. A case of Addison's disease with follow-up over a period of a year by CT is reported. CT showed the evolution of the adrenal glands from bilateral masses to small calcified glands. The differential diagnostic problems in the acute phase are also discussed.

Three-dimensional computed tomography of the acetabulum.

Acetabular fractures represent a complex variety that are classified in different types. Conventional radiology is often inadequate to demonstrate and classify the fractures. Computed tomography (CT) has already been shown to be superior in this field. A further advantage of CT is represented by the recent availability of three-dimensional (3D) images that are realized from axial CT scans by means of a new software. The Authors report the applications of this new software to the study of the normal acetabulum and in patients with fractures. 3D images allows an effective demonstration of the fracture, its irradiation and the dislocation of bone fragments. The information is contained in one or few images rather than many axial images. Therefore the role of 3D images may be considered complementary to axial CT scans.

Delayed CT in acute renal infection.

CT scans of the kidneys obtained approximately 3 hours after contrast administration often reveal useful information in patients with renal infections. In this article, we discuss three main features of these delayed scans. Feature 1 shows a nephrogram replacing a variable portion of the low density areas present in the early enhanced phase. The nephrogram can be streaky, band-like, cone or horseshoe-shaped; Feature 2 exhibits a focal staining or a hyperdense rim surrounding microabscesses and macroabscesses; Feature 3, very rare, is characterized by hyperdense areas located far from the lesions detected on early scans. These features make it possible to better define the actual extent of infection and the presence of the edema, improving diagnostic confidence.

Venous thromboembolism and melanoma.

The association between venous thromboembolism and cancer has been known for many years. The clotting system may be activated because of enhanced platelet aggregation and adhesion or by stimulation from the endothelial cells or the tumour cells themselves. Furthermore, thrombosis may develop as a result of prolonged immobilization, surgery, chemotherapy or hormone therapy. We present a case of a patient who underwent surgery for excision of a Clark level II melanoma on the back who developed pulmonary metastasis four years after the operation. The metastasis manifested with very severe venous thromboembolism which, despite anticoagulant therapy and the placement of a vena caval filter, led to the patient's death from pulmonary embolism. The case is uncommon, in terms of both the rarity with which venous thromboembolism is associated to melanoma, and the severity with which it manifested.

[Emergency surgery: suppurating urachal cyst producing intestinal occlusion]. / In tema di chirurgia d'urgenza: cisti uracale suppurata come causa di occlusione intestinale.

Urachal cysts are anomalies related to the persistence of urachal remnants after the birth. They are seldom asymptomatic, but in some cases they mimic acute abdominal disease. We report a case of a 67-year-old man with relapsing episodes of intestinal sub-occlusion caused by the presence of an infected urachal cyst. The surgical procedure we used consisted of a viscerolysis and excision of the infected cyst, avoiding partial resection of the dome of the urinary bladder. Our article also includes a review of the literature on urachal infected cyst and its management.

Renal artery stenosis: comparative evaluation of gadolinium-enhanced MRA and DSA.

PURPOSE: This study was undertaken to evaluate the accuracy of contrast-enhanced magnetic resonance angiography (CE-MRA) in detecting renal artery stenosis using intra-arterial digital subtraction angiography (DSA) as the gold standard. MATERIALS AND METHODS: Thirty-five consecutive patients with possible renovascular hypertension were prospectively studied; 26 of them underwent both MRA and DSA. In these 26 cases, two readers assessed the number of renal arteries, the presence of stenoses and their degree. Results were compared with DSA, and sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of MRA were determined. Interobserver variability was also calculated. RESULTS: DSA showed 51 main renal arteries (one patient had a single kidney) and six accessory arteries (total number of arteries 57) in the 26 patients considered. Both MRA readers detected all of the 51 main renal arteries and only one accessory vessel. When the presence of stenosis was considered, the readers' results, respectively, were as follows: sensitivity 77% and 72%, specificity 69% and 69%, PPV 86% and 85%, NPV 55% and 50% and diagnostic accuracy 75% and 71%. When the detection of significant stenosis was considered, the results, respectively, were: sensitivity 83% and 83%, specificity 73% and 78%, PPV 60% and 65%, NPV 90% and 91%, and diagnostic accuracy 76% and 80%. Interobserver variation was good when considering stenosis detection (kappa=0.69) and excellent when considering detection of significant stenosis (kappa=0.85). CONCLUSIONS: MRA results do not appear as positive as in the majority of papers in the literature. Multiple reasons can probably be invoked to explain this difference. The mean age of our patients, higher than in many other studies, should be noted and may have accounted for their possible poor cooperation. Moreover, all of the missed significant stenoses were distally located, and therefore, the failure to detect them might be related to the suboptimal spatial resolution of MRA. Nevertheless, MRA showed a high NPV for detecting significant stenoses, a finding of considerable clinical relevance in that it allows patients with normal MRA findings to be spared additional more invasive procedures.

Virtual angioscopy by means of three-dimensional rotational angiography of the aortoiliac arteries.

PURPOSE: The aim of this study was to report the different findings that can be visualised with virtual angioscopy starting from rotational angiography (RA) and three-dimensional (3D) image processing (3DRA) in the evaluation of the abdominal aorta and iliac arteries. MATERIALS AND METHODS: Fifty-seven patients showing an occlusive or aneurysmal disease of the abdominal aorta and iliac arteries underwent intraarterial digital subtraction angiography (DSA) equipped with the RA function and a 3D workstation. We found that 3DRA is able to generate images of the examined vessels with a very effective 3D appearance; furthermore, it is able to create images of the lumen and wall of the vessel through two different modalities: endoviews and cross sections. The possibility of matching high-density structures (i.e. calcified plaques and stents) to standard 3D reconstructions of the examined arteries was applied. RESULTS: Different aspects of the arteries can be demonstrated in the angioscopic elaborations: the normal and stenotic lumen, artery bifurcations, the collateral vessel origins and the severity and extensions of atheromatous calcifications and their relationships to the vessel wall. Virtual angioscopy is able to visualise some devices (catheters, stents) introduced during diagnostic and interventional procedures. CONCLUSIONS: The constant technological evolution of diagnostic imaging is offering new image-processing techniques, providing new types of previously unexplored information. We present a summary of the different radiological findings that can be demonstrated with this new imaging technique.

Endovascular treatment of endoleaks after endovascular abdominal aortic aneurysm repair: personal experience.

PURPOSE: This paper describes the different endovascular treatments (cuffs, endografts and embolisation) available for types I, II and III endoleaks occurring after endovascular abdominal aortic aneurysm repair (EVAR). MATERIALS AND METHODS: From January 2000 to June 2006, 134 patients (118 men, 16 women; mean age 75.1 years) underwent EVAR. Ten patients (7%) developed significant endoleaks requiring endovascular treatment. RESULTS: Five endoleaks were type I, two were type II and three were type III. Of the five type I endoleaks, four were proximal and one was distal. The proximal endoleaks were treated by cuff deployment, whereas the distal endoleak was treated with a bifurcated graft. Of the two patients with type II endoleak, one was treated by translumbar puncture and coil embolisation, and the other was treated by superselective embolisation of the lumbar feeding vessel with nonresorbable particles. Of the three patients with type III endoleak, two were treated by deploying an aortouniiliac endograft inside the bifurcated graft and the other by implanting a cuff to restore continuity between the graft body and the contralateral limb. Endovascular treatment was successful in 6/10 cases, whereas three cases required surgical conversion. One patient did not undergo surgery owing to poor general condition. CONCLUSIONS: The reported incidence of endoleaks after EVAR is 10%-20%. Significant endoleaks should be treated promptly. Endovascular treatment can be done with different techniques, but success in not constant due to adverse anatomical conditions and technical difficulties.

MR angiography versus intra-arterial digital subtraction angiography of the lower extremities: activity-based cost analysis.

PURPOSE: The aim of this study was to analyse the costs pertaining to the radiology department of magnetic resonance angiography (MRA) and intra-arterial digital subtraction angiography (DSA) in the evaluation of arterial disease of the lower limbs. MATERIALS AND METHODS: The differential cost of the two procedures, i.e. the sum of equipment costs (amortisation and service contract), variable costs (supplies and related services) and personnel costs (radiologist, radiographer and nurse) was determined. The common cost (auxiliary personnel and indirect internal costs) was also calculated. Finally, the full cost of the two procedures was obtained (sum of differential and common costs). RESULTS: The differential cost of MRA was 186.14 euro (equipment costs: 50.80 euro, variable costs: 75.04 euro, personnel costs: 60.30 euro) while the differential cost of intra-arterial DSA was 238.18 euro (equipment costs: 57.60 euro, variable costs: 90.13 euro, staff costs: 90.45 euro). The estimated common cost was 5.62 euro. Therefore, the full cost of MRA was 191.76 euro and the full cost of intra-arterial DSA was 243.80 euro (27.1% higher). DISCUSSION AND CONCLUSIONS: Intra-arterial DSA costs more than MRA, mainly because of the higher costs of supplies used during the procedure and higher personnel costs (as a result of the longer duration of intra-arterial DSA). It should be noted that our evaluation considers costs pertaining to the radiology department only. It is evident that an economic analysis considering hospital costs as well would result in much higher costs for DSA if post-procedure hospitalisation is required. Our results cannot be simply exported to other radiology departments since they refer to the technology and organisation adopted in our department. However, our cost analysis model can be easily applied to other environments. MRA provides good diagnostic accuracy in the evaluation of arteries of the lower extremities, and its biological cost is far lower than that of intra-arterial DSA (MRA is noninvasive, it does not use ionising radiation, and the contrast medium is safe). Its lower cost is another argument in favour of the use of MRA instead of intra-arterial DSA in the evaluation of lower-extremity arterial disease.

Three-dimensional rotational angiography of the carotid arteries with high-flow injection from the aortic arch. Preliminary experience.

PURPOSE: Three-Dimensional Rotational Angiography (3DRA) is a new technique based on a rotational angiographic acquisition able to display arterial vessels in a 3D rendering mode. The system was mainly developed for neuroradiological evaluations but preliminary extracranial experiences have also been reported. The aim of our work was to compare the results of three-dimensional angiography of the carotid arteries done with high-flow injection of contrast medium from the aortic arch with the results of selective angiography. MATERIALS AND METHODS: Twenty patients underwent digital angiography of the supra-aortic vessels in order to quantify a stenosis of the carotid bifurcations previously detected at Doppler Ultrasound. Examinations were performed with the Philips Integris Allura system provided with the rotational angiography (RA) tool connected to a workstation for three-dimensional reconstruction able to display vessels in a 3D fashion (Volume Rendering, Gradient Rendering, Shaded Surface Display), automatically remove bone structures (cervical spine, calcified plaque, etc.) and perform an automatic analysis of the vessel diameter and surface area at the point of major stenosis and in the disease-free vessel segments above and below. The carotid evaluation was done either with selective catheterization and the two standard AP and LL projections and with RA after contrast medium injection from the aortic arch followed by 3D reconstruction. RESULTS: The comparison of the selective angiography and three-dimensional images was possible in 37 out of 40 carotid bifurcations (3 internal carotid arteries were occluded) and a good diagnostic quality was obtained in 35 out of 37 cases with an high correlation in the degree of stenosis. In 2/37 cases with calcified plaques the degree of stenosis was effectively demonstrated only after electronic subtraction of the calcified component of the plaque. CONCLUSIONS: The technique we propose proved to be feasible in all cases with a good correlation in the quantification of the degree of stenosis. The practical advantage of our technique is the almost complete exclusion of risks of neurological complications due to selective catheterization, and reduced examination time.

[The imaging of chronic renal infections]. / Bildgebung chronischer renaler Infektionen.

From pathological point of view the chronic renal infections include two types, interstitial chronic pyelonephritis and granulomatous pyelonephritis, namely xanthogranulomatous, malacoplakia and renal tuberculosis. Indications for imaging modalities are more common compared to the acute types and allow to depict both factors causing obstruction and infection such as stones ant the renal and extrarenal extension of the disease. In this article the authors review the findings and the role of plain film and urography, computed tomography and ultrasonography.

[Arterial anatomy of the celiac trunk and the superior mesenteric artery with computerized tomography]. / Anatomia arteriosa del tripode celiaco e dell'arteria mesenterica superiore con la tomografia computerizzata.

A hundred patients with different conditions underwent CT and the results were retrospectively reviewed to evaluate the visibility of the celiac trunk, of its branches and of the superior mesenteric artery. Thirty-six patients underwent angiography too, which allowed the anatomical variants suspected on CT to be demonstrated, according to Kuhns' criteria. The other 64 patients were consecutively selected and only aneurysmal changes were not included. All examinations were performed using a General Electric 9800 Advantage scanner, with 2 second scanning time and 10 mm-thick contiguous scans. In 20 patients 5 mm contiguous scans were performed. All examinations followed i.v. injections of contrast agents which were given with an automatic injector. The cases with suspected anatomical variants on CT but with no angiographic confirmation were not considered. A hundred CT exams were retrospectively reviewed: the celiac trunk and the common hepatic artery were demonstrated in all of them. Visibility of the other branches was 40% for the hepatic artery, 53% for the right branch of the hepatic artery and 39% for its left branch, 70% for the gastroduodenal artery, 82% for the left gastric artery, 97% for the splenic artery and 100% for the superior mesenteric artery. As for the 36 patients who underwent both CT and angiography, right hepatic artery from the superior mesenteric artery was seen in 19% of cases with both modalities; common hepatic artery arising from the superior mesenteric artery was detected in 2% of cases. In both instances, these anatomical variants appeared as a vessel running posterior to the portal vein. The careful investigation of axial CT scans showed the level of origin of the artery from the superior mesenteric artery. These results are in agreement with the angiographic data reported in the literature. Our study demonstrated that the celiac trunk and its variants are always depicted by the new CT scanner. The knowledge of these variants may be useful in the patients to submit to liver surgery. The celiac trunk and its variants are demonstrated with conventional 10 mm slices. The use of 5 mm slices improves the visibility of thin anatomical branches but is not essential to recognize the major vessels and anatomical variants.

[Computerized tomography: problems and errors in the diagnosis of renal masses]. / La Tomografia Computerizzata: problemi ed errori nella diagnostica delle masse renali.

The diagnostic imaging of renal masses has greatly benefitted from US and CT. Nevertheless, a certain number of problems and errors are still present, and they must be discussed once more. In the authors' experience, problems and errors have 3 fundamental causes: operator, examination technique and complex patterns of renal masses. The latter is the most important cause of error in CT diagnosis. Complex patterns are seen in a limited number of cystic masses--i.e., hemorrhagic, inflammatory, and septated cysts, and cystic tumors. Hemorrhagic cysts, if hemorrhage is not recent, can cause some diagnostic difficulties since the typical high density of the recent hemorrhage is no longer present. Other renal masses may appear hyperdense on unenhanced CT scans, and therefore they must be considered in the differential diagnosis. Inflammatory cysts and abscesses are sometimes difficult to differentiate from other masses due to their aspecific appearance; clinical correlation is important in these instances to support CT diagnosis. Multiseptated cysts and cystic tumors cause huge problems of differential diagnosis. A good knowledge of differential CT findings is sure to reduce the problems in differentiating benign from malignant tumors and, among the latter, the different histotypes and metastases, when present as solitary masses. Also in this case, the correlation between CT, clinical history and other modalities can reduce the number of questionable cases.