Stress and selective attention: Immediate and delayed stress effects on inhibition of return.

The relationship between attention and stress is far from understood. In fact, some studies reported better attentional selection during and after stress, some studies reported worse attentional selection, and some studies reported no effects of stress on attentional selection at all. We argue that given the complexity of both concepts more data are needed as to ultimately understand this relationship. Here we use an established attentional task that yields the inhibition of return (IOR) effect which is assumed to tap attentional control of oculomotor behavior. Participants were stressed with a Cold Pressor Test (CPT) and immediate and delayed effects of stress on hypothalamus-pituitary-adrenal (HPA) axis activation and IOR were analyzed. IOR was neither by immediate nor by delayed after-effects of the CPT stress procedure modulated, instead, we observed reliable and significant IOR in all experimental conditions. Attentional control of oculomotor behavior is therefore not altered after CPT stress, nor related to the post-stress activity of the HPA axis.

Distractor inhibition: Evidence from lateralized readiness potentials.

The present study investigated distractor inhibition on the level of stimulus representation. In a sequential distractor-to-distractor priming task participants had to respond to target letters flanked by distractor digits. Reaction time and stimulus-locked lateralized readiness potentials (S-LRPs) of probe responses were measured. Distractor-target onset asynchrony was varied. For RTs responses to probe targets were faster in the case of prime-distractor repetition compared to distractor changes indicating distractor inhibition. Benefits in RTs and the latency of S-LRP onsets for distractor repetition were also modulated by distractor-target onset asynchrony. For S-LRPs distractor inhibition was only present with a simultaneous onset of distractors and target. The results confirm previous results indicating inhibitory mechanisms of object-based selective attention on the level of distractor representations.

Virtual reality in the diagnostic and therapy for mental disorders: A systematic review.

BACKGROUND: Virtual reality (VR) technologies are playing an increasingly important role in the diagnostics and treatment of mental disorders. OBJECTIVE: To systematically review the current evidence regarding the use of VR in the diagnostics and treatment of mental disorders. DATA SOURCE: Systematic literature searches via PubMed (last literature update: 9th of May 2022) were conducted for the following areas of psychopathology: Specific phobias, panic disorder and agoraphobia, social anxiety disorder, generalized anxiety disorder, posttraumatic stress disorder (PTSD), obsessive-compulsive disorder, eating disorders, dementia disorders, attention-deficit/hyperactivity disorder, depression, autism spectrum disorder, schizophrenia spectrum disorders, and addiction disorders. ELIGIBILITY CRITERIA: To be eligible, studies had to be published in English, to be peer-reviewed, to report original research data, to be VR-related, and to deal with one of the above-mentioned areas of psychopathology. STUDY EVALUATION: For each study included, various study characteristics (including interventions and conditions, comparators, major outcomes and study designs) were retrieved and a risk of bias score was calculated based on predefined study quality criteria. RESULTS: Across all areas of psychopathology, k = 9315 studies were inspected, of which k = 721 studies met the eligibility criteria. From these studies, 43.97% were considered assessment-related, 55.48% therapy-related, and 0.55% were mixed. The highest research activity was found for VR exposure therapy in anxiety disorders, PTSD and addiction disorders, where the most convincing evidence was found, as well as for cognitive trainings in dementia and social skill trainings in autism spectrum disorder. CONCLUSION: While VR exposure therapy will likely find its way successively into regular patient care, there are also many other promising approaches, but most are not yet mature enough for clinical application. REVIEW REGISTRATION: PROSPERO register CRD42020188436. FUNDING: The review was funded by budgets from the University of Bonn. No third party funding was involved.

Cardiac cycle time effects on selection efficiency in vision.

The effect of cardiac cycle time on attentional selection was investigated in an experiment in which participants classified target letters in a visual selection task. Stimulus onsets were aligned to the R wave of the electrocardiogram and stimuli presented either during the ventricular systole or diastole. Selection efficiency was operationalized as difference in target selection performance under conditions of homogeneous and heterogeneous distractors. Differences in performance (i.e., the impact selection difficulty had on the ability to select the target) were attenuated for stimuli presented during the ventricular systole compared to the diastole. Increased baroafferent signal transmission during the systole appears to reduce interference of highly distracting stimuli on visual selection efficiency.

Baroreceptor activity impacts upon controlled but not automatic distractor processing.

Changes within the cardiovascular system have been shown to alter sensorimotor and memory performance, pain perception as well as cortical arousal. This influence is assumed to be mediated by afferent feedback of baroreceptors that when stimulated exert inhibitory effects on cortical structures. Mainly responsible for short-term regulation of blood pressure, afferents of the baroreceptors are widely connected to subcortical and cortical structures like the insular cortex. A putative impact on cognitive control processes remains an open question, however. Using a sequential distractor priming task, the present study investigated whether inhibitory influences of baroreceptor activation apply to selective information processing in the presence of irrelevant information. In particular, we assessed distractor-response binding and Negative Priming as indices of automatic and controlled distractor processing, respectively. Baroreceptor activation was experimentally manipulated by the systematic variation of body position. The results showed that only Negative Priming but not distractor-response binding was modulated by body position suggesting that controlled but not automatic processing of distractors is affected by baroreceptor activity.

Cardiac cycle time effects on mask inhibition.

Research on the interaction of the cardiovascular and the central nervous system has demonstrated inhibitory effects associated with baroreceptor stimulation. One way of examining baroreceptor influence on behavior and central nervous processes is by making use of naturally occurring variations in baroreceptor stimulation in the course of the cardiac cycle. In terms of perceptual and sensorimotor processes, until today, research has focused primarily on cardiac cycle time effects on the perception of and reaction to simple stimuli. The present study is the first to investigate modulatory effects of variations in baroreceptor activity in the context of a more complex stimulus configuration using a visual masking task in which a target has to be selected against an interfering mask. The results suggest that baroreceptor stimulation enhances inhibitory processes needed to solve perceptual interference.