RESUMO
Multiparametric magnetic resonance (MR) imaging combines anatomic and functional imaging techniques for evaluating the prostate and is increasingly being used in diagnosis and management of prostate cancer. A wide spectrum of anatomic and pathologic processes in the prostate may masquerade as prostate cancer, complicating the imaging interpretation. The histopathologic and imaging findings of these potential mimics are reviewed. These entities include the anterior fibromuscular stroma, surgical capsule, central zone, periprostatic vein, periprostatic lymph nodes, benign prostatic hyperplasia (BPH), atrophy, necrosis, calcification, hemorrhage, and prostatitis. An understanding of the prostate zonal anatomy is helpful in distinguishing the anatomic entities from prostate cancer. The anterior fibromuscular stroma, surgical capsule, and central zone are characteristic anatomic features of the prostate with associated low T2 signal intensity due to dense fibromuscular tissue or complex crowded glandular tissue. BPH, atrophy, necrosis, calcification, and hemorrhage all have characteristic features with one or more individual multiparametric MR imaging modalities. Prostatitis constitutes a heterogeneous group of infective and inflammatory conditions including acute and chronic bacterial prostatitis, infective and noninfective granulomatous prostatitis, and malacoplakia. These entities are associated with variable clinical manifestations and are characterized by the histologic hallmark of marked inflammatory cellular infiltration. In some cases, these entities are indistinguishable from prostate cancer at multiparametric MR imaging and may even exhibit extraprostatic extension and lymphadenopathy, mimicking locally advanced prostate cancer. It is important for the radiologists interpreting prostate MR images to be aware of these pitfalls for accurate interpretation. Online supplemental material is available for this article.
Assuntos
Calcinose/patologia , Imageamento por Ressonância Magnética/métodos , Próstata/patologia , Hiperplasia Prostática/patologia , Neoplasias da Próstata/patologia , Prostatite/diagnóstico , Atrofia/patologia , Humanos , Aumento da Imagem/métodos , Masculino , Patologia , Estatística como AssuntoRESUMO
Unusual imaging features of urothelial cancer of the renal pelvicaliceal system can be challenging for any radiologist. These manifestations include noncalcified and calcified focal infiltrative parenchymal masses, incidentally detected tumors in a hydronephrotic kidney due to ureteropelvic junction obstruction, transpelvic infiltrating solid masses extending through the retroperitoneum, and tumors primarily invading the perirenal fat. Less common manifestations include massive papillary frond-like projections within a large hydronephrotic sac, large multiloculated cystic masses with thick and irregular septa, tumors invading the renal vein, and paraaortic lymph node metastases as the only sign of an undetectable primary tumor of the renal collecting system. Radiologists should be aware that an eccentric, focal, infiltrative pelvicaliceal carcinoma that causes distortion of the renal contour may simulate renal cell carcinoma; when calcified, such a pelvicaliceal carcinoma may simulate chronic inflammatory renal disease. The radiologist should also be aware of the importance of a meticulous sonographic evaluation of a hydronephrotic kidney, particularly in older patients, to avoid missing a urothelial cancer. When a nonfunctioning and enlarged kidney is present, radiologists should always consider infiltrative hydronephrotic urothelial carcinoma as a diagnostic possibility. Familiarity with unusual imaging features of urothelial cancer of the renal pelvicaliceal system may facilitate making the correct diagnosis, thus enabling adequate therapeutic management.
Assuntos
Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células de Transição/diagnóstico , Diagnóstico por Imagem , Cálices Renais/patologia , Neoplasias Renais/diagnóstico , Pelve Renal/patologia , Neoplasias Urológicas/diagnóstico , Urotélio/patologia , Calcinose , Carcinoma de Células Escamosas/patologia , Carcinoma de Células de Transição/patologia , Diagnóstico Diferencial , Humanos , Neoplasias Renais/patologia , Neoplasias Urológicas/patologiaRESUMO
PURPOSE: This prospective study was performed to achieve visualization of the reestablishment of anatomy after reconstructive surgery in the different pelvic compartments with non-absorbable radiopaque meshes, providing valuable anatomic information for surgeons implanting meshes. MATERIALS AND METHODS: A total of 30 female patients with stress urinary incontinence (SUI), anterior and posterior vaginal wall prolapse, or both underwent surgical repair using radiopaque meshes after written informed consent. Patients with SUI underwent five different surgeries. Patients with anterior vaginal prolapse underwent a procedure using a combined pre-pubic and transobturator mesh, and those with posterior vaginal prolapse underwent posterior slingplasty. Three-dimensional reconstruction using helical CT was performed four weeks postoperatively. RESULTS: In all cases, the mesh was clearly visualized. Transobturator slings were shown at the midurethra, and the anchoring tails perforated the obturator foramen at the safety region. Mini-slings were in the proper place, and computed angiography revealed that the anchoring system was away from the obturator vessels. In patients undergoing procedure for anterior vaginal prolapse, both pre-pubic armpit and obturator slings were clearly seen and the mesh was in the proper position, supporting the bladder base and occluding the distal part of the urogenital hiatus. Transcoccygeal sacropexy revealed indirectly a well-supported "neo rectovaginal fascia" and the anchoring tails at the level of ischial spines. CONCLUSION: Three-dimensional helical tomography images of the female pelvis using radiopaque meshes have a potential role in improving our understanding of pelvic floor reconstructive surgeries. These radiopaque meshes might be the basis of a new investigative methodology.
Assuntos
Imageamento Tridimensional/métodos , Diafragma da Pelve/cirurgia , Telas Cirúrgicas , Tomografia Computadorizada Espiral/métodos , Incontinência Urinária por Estresse/cirurgia , Prolapso Uterino/cirurgia , Feminino , Humanos , Diafragma da Pelve/anatomia & histologia , Estudos Prospectivos , Interpretação de Imagem Radiográfica Assistida por Computador/métodos , Slings Suburetrais , Resultado do TratamentoRESUMO
Prostatic atrophy which represents a form of adaptive response to injury most commonly to inflammation and/or chronic ischemia is a histological abnormality frequently found in prostate biopsies and autopsies. Although commonly found, this lesion is rarely reported in the prostatic biopsy reports. It is well known that histologically focal prostatic atrophy (FPA) is one of the most frequent mimics of prostatic adenocarcinoma. On conventional and color Doppler transrectal ultrasound and on magnetic resonance spectroscopic imaging studies (MRSI), FPA may also simulate prostate cancer. Thus, this entity should be considered together with prostatitis as an important cause of false-positive results in MRSI of the prostate. It has been shown that there is a positive and significant association between extent of FPA in biopsies and serum total or free PSA elevation. For this reason, pathologists should include the presence of FPA in the pathology report of a prostatic biopsy, particularly in those patients with absence of cancer. When extensive FPA is the only finding in patients with several negative prostatic biopsies, this lesion may be the source for PSA elevation.
Assuntos
Espectroscopia de Ressonância Magnética , Próstata/diagnóstico por imagem , Próstata/patologia , Adenocarcinoma/diagnóstico , Adenocarcinoma/diagnóstico por imagem , Atrofia , Biópsia , Diagnóstico Diferencial , Humanos , Imageamento Tridimensional , Masculino , Antígeno Prostático Específico/sangue , Neoplasias da Próstata/diagnóstico , Neoplasias da Próstata/diagnóstico por imagem , Reto/diagnóstico por imagem , Ultrassonografia Doppler em CoresRESUMO
OBJECTIVE: Although non-contrast MR angiography (NC-MRA) is well established for the evaluation of renal artery stenosis, its usefulness in the evaluation of other abdominal aortic branches remains to be studied. This study aimed at evaluating the image quality and diagnostic accuracy of NC-MRA using a three-dimensional balanced steady-state free-precession sequence in identifying stenosis in the celiac trunk (CTR) and superior mesenteric artery (SMA) as compared with CT angiography (CTA) as the reference standard. METHODS: 41 patients underwent both NC-MRA and CTA of the abdominal aorta. Two radiologists analyzed the quality of the images (diagnostic vs non-diagnostic) and the performance (accuracy, sensitivity and specificity) of NC-MRA for the identification of arterial stenosis. Kappa tests were used to determine the interobserver agreement and the intermethod agreement between NC-MRA and CTA. RESULTS: NC-MRA provided diagnostic quality images of the CTR and SMA in 87.8% and 90.2% of cases, respectively, with high interobserver agreement (kappa 0.95 and 0.80, respectively). For stenosis assessment, NC-MRA had a sensitivity of 100%, a positive-predictive value of 50% and a negative-predictive value of 100% for both segments, with accuracies of 88.8% for the CTR and 94.5% for the SMA. CONCLUSION: NC-MRA is an accurate method for detecting stenosis in the CTR and SMA. Advances in knowledge: Data from this study suggest that MR angiography with balanced steady-state free-precession sequence is a viable non-contrast alternative for stenosis evaluation of these branches in patients for whom a contrast-enhanced examination is contraindicated.
Assuntos
Arteriopatias Oclusivas/diagnóstico por imagem , Artéria Celíaca/diagnóstico por imagem , Angiografia por Tomografia Computadorizada/métodos , Imageamento Tridimensional/métodos , Angiografia por Ressonância Magnética/métodos , Artéria Mesentérica Superior/diagnóstico por imagem , Oclusão Vascular Mesentérica/diagnóstico por imagem , Adulto , Idoso , Idoso de 80 Anos ou mais , Constrição Patológica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Reprodutibilidade dos TestesRESUMO
Unusual radiologic manifestations of a renal cell carcinoma (RCC) can present a diagnostic challenge. These manifestations include bilateral synchronous multifocal tumors, a small RCC with synchronous adrenal metastasis, and RCC associated with bulky abdominal lymphoma. Less common manifestations include multiseptated cystic carcinoma simulating a moderately complex renal cyst at ultrasonography (US), paraaortic metastatic adenopathy as the only sign of an undetectable primary renal neoplasm, RCC causing a large arteriovenous fistula, RCC simulating angiomyolipoma, and a nonfunctioning kidney due to transparenchymal renal propagation of cancer associated with a tumor thrombus occluding the renal vein. Radiologists should be aware of the possibility of tumor multifocality or of adrenal metastases from a high-grade small renal tumor, as well as of the association of RCC with lymphoma. They should also be aware of the importance of following up a multiseptated cystic mass found at US or a Bosniak category IIF renal cyst, since these lesions can serve as early indicators of cystic carcinoma. Because the clinical implications of and therapeutic strategies for RCC vary depending on imaging characterization of the nature and extent of the disease, familiarity with its more unusual radiologic manifestations facilitates accurate diagnosis and management.
Assuntos
Carcinoma de Células Renais/diagnóstico , Neoplasias Renais/diagnóstico , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma de Células Renais/diagnóstico por imagem , Carcinoma de Células Renais/secundário , Feminino , Humanos , Neoplasias Renais/diagnóstico por imagem , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Neoplasias Primárias Múltiplas , Estudos Retrospectivos , Tomografia Computadorizada por Raios X , UltrassonografiaRESUMO
In the appropriate clinical setting, certain aspects of extranodal abdominal lymphoma, as revealed by current cross-sectional imaging techniques, should be considered potentially diagnostic and can hasten the diagnosis. In addition, diagnostic imaging in the context of biopsy-proven lymphoma can accurately stage the disease for its appropriate treatment. The purpose of this article was to illustrate the various imaging aspects of extranodal lymphoma in the abdomen.
O linfoma extranodal abdominal tem um espectro de manifestações radiológicas que, no contexto clínico adequado, permite que o radiologista, ao considerar corretamente esta hipótese, otimize o seu diagnóstico e sua terapia. Além disso, depois de comprovado por biópsia, o linfoma pode ser estadiado e a resposta ao tratamento, avaliada pelos métodos de imagem. O presente ensaio iconográfico tem como objetivo ilustrar os diferentes achados por imagem do acometimento extranodal no linfoma abdominal.
RESUMO
Renal cell carcinoma (RCC) is the seventh most common histological type of cancer in the Western world and has shown a sustained increase in its prevalence. The histological classification of RCCs is of utmost importance, considering the significant prognostic and therapeutic implications of its histological subtypes. Imaging methods play an outstanding role in the diagnosis, staging and follow-up of RCC. Clear cell, papillary and chromophobe are the most common histological subtypes of RCC, and their preoperative radiological characterization, either followed or not by confirmatory percutaneous biopsy, may be particularly useful in cases of poor surgical condition, metastatic disease, central mass in a solitary kidney, and in patients eligible for molecular targeted therapy. New strategies recently developed for treating renal cancer, such as cryo and radiofrequency ablation, molecularly targeted therapy and active surveillance also require appropriate preoperative characterization of renal masses. Less common histological types, although sharing nonspecific imaging features, may be suspected on the basis of clinical and epidemiological data. The present study is aimed at reviewing the main clinical and imaging findings of histological RCC subtypes.
Os carcinomas de células renais (CCRs) são o sétimo tipo histológico de câncer mais comum no mundo ocidental e vêm apresentando uma tendência mantida de aumento em sua prevalência. A classificação histológica dos CCRs é de extrema importância, uma vez que a determinação dos subtipos histológicos tem significativas implicações prognósticas e terapêuticas. Os métodos de imagem têm destacada importância no diagnóstico, estadiamento e seguimento dos pacientes com CCR. As variantes histológicas mais comuns são células claras, papilífero e cromófobo. A caracterização radiológica dos subtipos de CCRs, seguida ou não de biópsia percutânea confirmatória, é particularmente útil em pacientes sem adequadas condições cirúrgicas, pacientes com doença metastática, pacientes com rim único e lesão central, e em pacientes candidatos a terapia de alvo molecular. As novas estratégias, recentemente desenvolvidas, para o tratamento do câncer renal, como crio e radiofrequência, terapia molecular alvo e vigilância ativa também exigem adequada caracterização pré-operatória das massas renais. Os subtipos histológicos menos comuns, apesar de não terem achados de imagem específicos, podem ser suspeitados com base em dados clínicos e epidemiológicos.
RESUMO
Prostatic atrophy may be histologically and at ultrasound similar to adenocarcinoma causing diagnostic confusion, its frequency increases with age but the etiopathogenesis is unknown. Based on a systematic study in autopsies previously done by one of us, ischemia due to local intense arteriosclerosis seems to be a potential factor for its pathogenesis. Absent blood flow in areas of prostatic atrophy might be a further evidence for a possible role of ischemia. From a total of 298 patients biopsied and studied by gray-scale and color Doppler transrectal ultrasound in the period 1998 to 2001, 33 patients had suspicious lesions (37 hypoechoic nodules and 3 heterogeneous lesions) showing prostatic atrophy as the only diagnosis on all these biopsied lesions. Adenocarcinoma, high-grade intraepithelial neoplasia or other atypical lesions were absent in all patients. On color Doppler the suspicious areas showed absent flow in 24/40 (60%), present flow in 12/40 (30%), and increased flow in 4/40 (10%) of the lesions. Absent flow in the majority of the lesions studied may be a further evidence for a possible role of local ischemia in the etiopathogenesis of prostatic atrophy.
Assuntos
Isquemia/diagnóstico por imagem , Isquemia/patologia , Próstata/patologia , Adulto , Idoso , Atrofia/diagnóstico por imagem , Atrofia/etiologia , Diagnóstico Diferencial , Humanos , Isquemia/complicações , Masculino , Pessoa de Meia-Idade , Próstata/irrigação sanguínea , Próstata/diagnóstico por imagem , Ultrassonografia Doppler em CoresRESUMO
The involvement of the retroperitoneum by endometriosis occurs only sporadically. In the present report, emphasis will be given to the magnetic resonance imaging findings which raised the diagnostic suspicion of periureteral lesion in a patient undergoing tamoxifen therapy, presenting with left upper quadrant pain and hydronephrosis. Histopathological findings obtained by means of computed tomography-guided percutaneous biopsy revealed the diagnosis of periureteral endometriosis.
O acometimento por endometriose do retroperitônio é infrequente. Será dada importância aos achados da ressonância magnética que permitiram a suspeita diagnóstica de lesão periureteral em uma paciente em uso de tamoxifeno e que se apresentou com dor lombar esquerda e hidronefrose. Os achados histopatológicos obtidos por intermédio de biópsia percutânea orientada por tomografia computadorizada permitiram o diagnóstico de endometriose periureteral.
RESUMO
CONTEXT: Extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. CASE REPORT: This report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. The patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. It was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. Immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral S100 protein expression in sustentacular cells. Succinate dehydrogenase A and B-related (SDHA and SDHB) expression was present in both tumors. CONCLUSIONS: No genetic alterations to the VHL and SDHB genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary syndrome that could explain the association between paraganglioma and chromophobe renal cell carcinoma in a patient with arterial hypertension.
Assuntos
Carcinoma de Células Renais/patologia , Neoplasias dos Genitais Masculinos/patologia , Neoplasias Renais/patologia , Neoplasias Primárias Múltiplas/patologia , Paraganglioma/patologia , Glândulas Seminais/patologia , Diagnóstico Diferencial , Neoplasias dos Genitais Masculinos/genética , Humanos , Hipertensão/etiologia , Masculino , Pessoa de Meia-Idade , Neoplasias Primárias Múltiplas/genética , Paraganglioma/genética , Succinato Desidrogenase/genética , Proteína Supressora de Tumor Von Hippel-Lindau/genéticaRESUMO
Abstract In the appropriate clinical setting, certain aspects of extranodal abdominal lymphoma, as revealed by current cross-sectional imaging techniques, should be considered potentially diagnostic and can hasten the diagnosis. In addition, diagnostic imaging in the context of biopsy-proven lymphoma can accurately stage the disease for its appropriate treatment. The purpose of this article was to illustrate the various imaging aspects of extranodal lymphoma in the abdomen.
Resumo O linfoma extranodal abdominal tem um espectro de manifestações radiológicas que, no contexto clínico adequado, permite que o radiologista, ao considerar corretamente esta hipótese, otimize o seu diagnóstico e sua terapia. Além disso, depois de comprovado por biópsia, o linfoma pode ser estadiado e a resposta ao tratamento, avaliada pelos métodos de imagem. O presente ensaio iconográfico tem como objetivo ilustrar os diferentes achados por imagem do acometimento extranodal no linfoma abdominal.
RESUMO
Abstract Renal cell carcinoma (RCC) is the seventh most common histological type of cancer in the Western world and has shown a sustained increase in its prevalence. The histological classification of RCCs is of utmost importance, considering the significant prognostic and therapeutic implications of its histological subtypes. Imaging methods play an outstanding role in the diagnosis, staging and follow-up of RCC. Clear cell, papillary and chromophobe are the most common histological subtypes of RCC, and their preoperative radiological characterization, either followed or not by confirmatory percutaneous biopsy, may be particularly useful in cases of poor surgical condition, metastatic disease, central mass in a solitary kidney, and in patients eligible for molecular targeted therapy. New strategies recently developed for treating renal cancer, such as cryo and radiofrequency ablation, molecularly targeted therapy and active surveillance also require appropriate preoperative characterization of renal masses. Less common histological types, although sharing nonspecific imaging features, may be suspected on the basis of clinical and epidemiological data. The present study is aimed at reviewing the main clinical and imaging findings of histological RCC subtypes.
Resumo Os carcinomas de células renais (CCRs) são o sétimo tipo histológico de câncer mais comum no mundo ocidental e vêm apresentando uma tendência mantida de aumento em sua prevalência. A classificação histológica dos CCRs é de extrema importância, uma vez que a determinação dos subtipos histológicos tem significativas implicações prognósticas e terapêuticas. Os métodos de imagem têm destacada importância no diagnóstico, estadiamento e seguimento dos pacientes com CCR. As variantes histológicas mais comuns são células claras, papilífero e cromófobo. A caracterização radiológica dos subtipos de CCRs, seguida ou não de biópsia percutânea confirmatória, é particularmente útil em pacientes sem adequadas condições cirúrgicas, pacientes com doença metastática, pacientes com rim único e lesão central, e em pacientes candidatos a terapia de alvo molecular. As novas estratégias, recentemente desenvolvidas, para o tratamento do câncer renal, como crio e radiofrequência, terapia molecular alvo e vigilância ativa também exigem adequada caracterização pré-operatória das massas renais. Os subtipos histológicos menos comuns, apesar de não terem achados de imagem específicos, podem ser suspeitados com base em dados clínicos e epidemiológicos.
RESUMO
O acometimento por endometriose do retroperitônio é infrequente. Será dada importância aos achados da ressonância magnética que permitiram a suspeita diagnóstica de lesão periureteral em uma paciente em uso de tamoxifeno e que se apresentou com dor lombar esquerda e hidronefrose. Os achados histopatológicos obtidos por intermédio de biópsia percutânea orientada por tomografia computadorizada permitiram o diagnóstico de endometriose periureteral.
The involvement of the retroperitoneum by endometriosis occurs only sporadically. In the present report, emphasis will be given to the magnetic resonance imaging findings which raised the diagnostic suspicion of periureteral lesion in a patient undergoing tamoxifen therapy, presenting with left upper quadrant pain and hydronephrosis. Histopathological findings obtained by means of computed tomography-guided percutaneous biopsy revealed the diagnosis of periureteral endometriosis.
RESUMO
OBJECTIVE: To present the spectrum of abnormalities found at endorectal magnetic resonance imaging (E-MRI), in patients with persistent hemospermia. MATERIALS AND METHODS: A review of E-MRI findings observed in 86 patients with persistent hemospermia was performed and results compared with those reported in the literature. Follow-up was possible in 37 of 86 (43%) patients with hemospermia. RESULTS: E-MRI showed abnormal findings in 52 of 86 (60%) patients with hemospermia. These findings were: a) hemorrhagic seminal vesicle and ejaculatory duct, isolated (n = 11 or 21%) or associated with complicated midline prostatic cyst (n = 10 or 19.0%); b) hemorrhagic chronic seminal vesiculitis, isolated (n = 14 or 27%) or associated with calculi within dilated ejaculatory ducts (n = 2 or 4 %); c) hemorrhagic seminal vesicle associated with calculi within dilated ejaculatory duct (n = 4 or 7.7%) or within seminal vesicle (n = 4 or 7.7%); d) non-complicated midline prostatic cyst (n = 6 or 11.5%); and e) prostate cancer (n = 1 or 2%). Successful treatment was more frequent in patients with chronic inflammatory and/or obstructive abnormalities. CONCLUSION: E-MRI should be considered the modality of choice, for the evaluation of patients with persistent hemospermia.
Assuntos
Ductos Ejaculatórios , Hemospermia/etiologia , Imageamento por Ressonância Magnética/métodos , Glândulas Seminais , Adulto , Idoso , Cistos/complicações , Cistos/diagnóstico , Doenças dos Genitais Masculinos/complicações , Doenças dos Genitais Masculinos/diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias da Próstata/complicações , Neoplasias da Próstata/diagnósticoRESUMO
OBJECTIVES: Prostatic atrophy is one of the most frequent benign mimics of prostate adenocarcinoma. Regardless of the cause, we hypothesized that damaged epithelial cells in the atrophic acini could be a source of the elevation of serum prostate-specific antigen (PSA). The aim of this study was to find any possible association between the extent of prostatic atrophy in needle biopsies and serum PSA level. METHODS: The study was based on 131 needle prostatic biopsies corresponding to 107 patients. The only diagnosis in all biopsies was focal prostatic atrophy without the presence of cancer, high-grade prostatic intraepithelial neoplasia, or areas suspicious for cancer. The extent of atrophy was measured in two ways: the linear extent in millimeters and the percentage of linear extent showing atrophy for each biopsy. Spearman's coefficient of rank correlation was used to evaluate the association of atrophy extent with total and free serum PSA levels. RESULTS: A positive and statistically significant correlation was found between the linear atrophy extent and the total serum PSA level (r = 0.25, P = <0.01) and free PSA level (r = 0.23, P = 0.01). A positive and statistically significant correlation was found between the percentage of the linear extent showing atrophy and the total serum PSA level (r = 0.23, P = 0.01) and free PSA level (r = 0.20, P = 0.02). CONCLUSIONS: A positive and significant association was found between the extent of atrophy and the total or free serum PSA elevation. The findings suggest that damaged epithelial cells in atrophic acini, regardless of cause, could be a source of serum PSA elevation.
Assuntos
Adenocarcinoma/patologia , Antígeno Prostático Específico/análise , Neoplasias da Próstata/patologia , Prostatite/patologia , Adenocarcinoma/diagnóstico , Idoso , Idoso de 80 Anos ou mais , Atrofia/patologia , Biópsia por Agulha , Estudos de Coortes , Diagnóstico Diferencial , Humanos , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Probabilidade , Neoplasias da Próstata/diagnóstico , Prostatite/diagnóstico , Fatores de Risco , Sensibilidade e Especificidade , Índice de Gravidade de DoençaRESUMO
CONTEXT: Extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. CASE REPORT: This report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. The patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. It was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. Immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral S100 protein expression in sustentacular cells. Succinate dehydrogenase A and B-related (SDHA and SDHB) expression was present in both tumors. CONCLUSIONS: No genetic alterations to the VHL and SDHB genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary syndrome that could explain the association between paraganglioma and chromophobe renal cell carcinoma in a patient with arterial hypertension.
CONTEXTO: Paragangliomas extra-adrenais são tumores raros que têm sido relatados em muitas localizações, incluindo rim, uretra, bexiga, próstata, cordão espermático, vesícula biliar, útero e vagina. RELATO DE CASO: Este relato descreve, pela primeira vez em nosso conhecimento, um paraganglioma primário da vesícula seminal ocorrendo em um paciente do sexo masculino de 61 anos de idade. O paciente apresentou hipertensão arterial persistente e um diagnóstico prévio de carcinoma de células renais cromófobo (CCRC). Foi pensado que o tumor de vesícula seminal poderia ser uma metástase do CCRC. A caracterização imunoistoquímica revelou expressão de sinaptofisina e cromogranina nos ninhos de células tumorais e expressão de proteína S100 nas células sustentaculares. Expressão de succinato de-hidrogenase A e B relacionada (SDHA e SDHB) estiveram presentes em ambos os tumores CONCLUSÕES: Nenhuma alteração genética dos genes VHL e SDHB foi detectada nos tecidos tumorais e adjacentes ao tumor, o que nos levou a afastar uma síndrome hereditária que poderia explicar a associação entre o paraganglioma e o CCRC em um paciente com hipertensão arterial.
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Carcinoma de Células Renais/patologia , Neoplasias dos Genitais Masculinos/patologia , Neoplasias Renais/patologia , Neoplasias Primárias Múltiplas/patologia , Paraganglioma/patologia , Glândulas Seminais/patologia , Diagnóstico Diferencial , Neoplasias dos Genitais Masculinos/genética , Hipertensão/etiologia , Neoplasias Primárias Múltiplas/genética , Paraganglioma/genética , Succinato Desidrogenase/genética , Proteína Supressora de Tumor Von Hippel-Lindau/genéticaRESUMO
Myelomeningocele (MM) is a congenital neural tube defect with serious consequences, including hydrocephaly. An important hope for intrauterine repair is that hydrocephaly may be prevented by reversing the Arnold-Chiari malformation. Three medical centers in the United States are doing trials with this objective. We describe an intrauterine correction of MM in a Brazilian research center of fetal medicine, which resulted in abruptio placentae and fetal death, to illustrate factors that influence fetal-maternal risks during this surgical procedure.
Assuntos
Descolamento Prematuro da Placenta/etiologia , Complicações Intraoperatórias/etiologia , Meningomielocele/cirurgia , Descolamento Prematuro da Placenta/patologia , Adulto , Feminino , Humanos , Meningomielocele/complicações , Gravidez , Fatores de RiscoRESUMO
Diverticulite jejunal é doença rara que acomete principalmente os idosos. Os sintomas e sinais clínicos são inespecíficos, fato que dificulta e retarda o diagnóstico. A tomografia computadorizada é muito valiosa na definição do diagnóstico. Neste relato será apresentado um caso de diverticulose jejunal complicada com diverticulite aguda perfurada bloqueada, assim como uma discussão breve sobre diverticulite jejunal e suas complicações.
Jejunal diverticulitis is a rare disease that primarily affects the elderly. Clinical signs and symptoms are nonspecific, a fact that complicates and delays the diagnosis. Computed tomography is very valuable in defining the diagnosis. The present report describes a case of jejunal diverticulosis complicated with acute perforated obstructive diverticulitis, and presents a brief discussion on jejunal diverticulitis and its complications.