Detalhe da pesquisa
1.
Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M ß-Lactamases: Biochemical and Structural Analyses.
Antimicrob Agents Chemother
; 67(1): e0093022, 2023 01 24.
Artigo
Inglês
| MEDLINE | ID: mdl-36602311
2.
Natural protein engineering in the Ω-loop: the role of Y221 in ceftazidime and ceftolozane resistance in Pseudomonas-derived cephalosporinase.
Antimicrob Agents Chemother
; 67(11): e0079123, 2023 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37850746
3.
Straightforward synthesis of chiral non-racemic α-boryl isocyanides.
Org Biomol Chem
; 19(30): 6687-6691, 2021 08 05.
Artigo
Inglês
| MEDLINE | ID: mdl-34286797
4.
Structural Insights into Inhibition of the Acinetobacter-Derived Cephalosporinase ADC-7 by Ceftazidime and Its Boronic Acid Transition State Analog.
Antimicrob Agents Chemother
; 64(12)2020 11 17.
Artigo
Inglês
| MEDLINE | ID: mdl-32988830
5.
Small-molecule inhibitors prevent the genotoxic and protumoural effects induced by colibactin-producing bacteria.
Gut
; 65(2): 278-85, 2016 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-25588406
6.
Crystal Structures of KPC-2 and SHV-1 ß-Lactamases in Complex with the Boronic Acid Transition State Analog S02030.
Antimicrob Agents Chemother
; 60(3): 1760-6, 2016 Jan 04.
Artigo
Inglês
| MEDLINE | ID: mdl-26729491
7.
Boronic Acid Transition State Inhibitors Active against KPC and Other Class A ß-Lactamases: Structure-Activity Relationships as a Guide to Inhibitor Design.
Antimicrob Agents Chemother
; 60(3): 1751-9, 2016 Jan 04.
Artigo
Inglês
| MEDLINE | ID: mdl-26729496
8.
Structure-based approach for identification of novel phenylboronic acids as serine-ß-lactamase inhibitors.
J Comput Aided Mol Des
; 30(10): 851-861, 2016 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27632226
9.
Ligand-Induced Proton Transfer and Low-Barrier Hydrogen Bond Revealed by X-ray Crystallography.
J Am Chem Soc
; 137(25): 8086-95, 2015 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26057252
10.
Synthesis of 1,2,3-triazol-1-yl-methaneboronic acids via click chemistry: an easy access to a new potential scaffold for protease inhibitors.
European J Org Chem
; 2015(5): 1075-1083, 2015 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26257579
11.
Fragment-guided design of subnanomolar ß-lactamase inhibitors active in vivo.
Proc Natl Acad Sci U S A
; 109(43): 17448-53, 2012 Oct 23.
Artigo
Inglês
| MEDLINE | ID: mdl-23043117
12.
Biochemical and structural analysis of inhibitors targeting the ADC-7 cephalosporinase of Acinetobacter baumannii.
Biochemistry
; 53(48): 7670-9, 2014 Dec 09.
Artigo
Inglês
| MEDLINE | ID: mdl-25380506
13.
Interactions of oximino-substituted boronic acids and ß-lactams with the CMY-2-derived extended-spectrum cephalosporinases CMY-30 and CMY-42.
Antimicrob Agents Chemother
; 57(2): 968-76, 2013 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-23229484
14.
Defining the minimum inhibitory concentration of 22 rifamycins in iron limited, physiologic medium against Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae clinical isolates.
PLoS One
; 18(6): e0287102, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37310985
15.
Sulfonamidoboronic Acids as "Cross-Class" Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to Combat Resistance in Acinetobacter baumannii.
Antibiotics (Basel)
; 12(4)2023 Mar 24.
Artigo
Inglês
| MEDLINE | ID: mdl-37107006
16.
Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter-Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum.
J Med Chem
; 66(13): 8510-8525, 2023 07 13.
Artigo
Inglês
| MEDLINE | ID: mdl-37358467
17.
Optically active α-phenylethylamine as efficient organocatalyst in the solvent-free reactions between 2,3-butanedione and conjugated nitroolefins.
Chirality
; 24(12): 1005-12, 2012 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-22836830
18.
Unexpected tricovalent binding mode of boronic acids within the active site of a penicillin-binding protein.
J Am Chem Soc
; 133(28): 10839-48, 2011 Jul 20.
Artigo
Inglês
| MEDLINE | ID: mdl-21574608
19.
Novel insights into the mode of inhibition of class A SHV-1 beta-lactamases revealed by boronic acid transition state inhibitors.
Antimicrob Agents Chemother
; 55(1): 174-83, 2011 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-21041505
20.
Insights Into the Inhibition of MOX-1 ß-Lactamase by S02030, a Boronic Acid Transition State Inhibitor.
Front Microbiol
; 12: 720036, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34970229