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1.
Skeletal Radiol ; 50(8): 1557-1565, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-33410965

RESUMO

OBJECTIVE: To identify if morphology of the entering and exiting nerve involved by a nerve sheath tumour in the brachial plexus can help differentiate between benign (B) and malignant (M) peripheral nerve sheath tumours (PNSTs). MATERIALS AND METHODS: Retrospective review of 85 patients with histologically confirmed primary PNSTs of the brachial plexus over a 12.5-year period. Clinical data and all available MRI studies were independently evaluated by 2 consultant musculoskeletal radiologists blinded to the final histopathological diagnosis assessing for maximal lesion dimension, visibility and morphology of the entering and exiting nerve, and other well-documented features of PNSTs. RESULTS: The study included 47 males and 38 females with mean age 46.7 years (range, 8-81 years). There were 73 BPNSTs and 12 MPNSTs. The entering nerve was not identified in 5 (7%), was normal in 17 (23%), was tapered in 38 (52%) and showed lobular enlargement in 13 (18%) BPNSTs compared with 0 (0%), 0 (0%), 2 (17%) and 10 (83%) MPNSTs respectively. The exiting nerve was not identified in 5 (7%), was normal in 20 (27%), was tapered in 42 (58%) and showed lobular enlargement in 6 (8%) BPNSTs compared with 4 (33%), 0 (0%), 2 (17%) and 6 (50%) MPNSTs respectively. Increasing tumour size, entering and exiting nerve morphology and suspected MRI diagnosis were statistically significant differentiators between BPNST and MPNST (p < 0.001). IOC for nerve status was poor to fair but improved to good if normal/tapered appearance were considered together with improved specificity of 81-91% for BPNST and sensitivity of 75-83%. CONCLUSIONS: Morphology of the adjacent nerve is a useful additional MRI feature for distinguishing BPNST from MPNST of the brachial plexus.


Assuntos
Plexo Braquial , Neoplasias de Bainha Neural , Neurofibrossarcoma , Plexo Braquial/diagnóstico por imagem , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Neoplasias de Bainha Neural/diagnóstico por imagem , Estudos Retrospectivos
2.
Skeletal Radiol ; 50(5): 993-1005, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33078239

RESUMO

OBJECTIVE: Intra-medullary tumour length is accurately assessed on T1-weighted turbo spin echo (T1W TSE) MRI which can be relatively time consuming, whilst the gradient echo Dixon (T1W GrE Dixon) technique is a rapid sequence (imaging time ~ 30 s). The aim of this study was to determine if the out-of-phase Dixon (OP T1W GrE Dixon) sequence can produce equivalent measurements of intra-medullary tumour length compared to the T1W TSE sequence. MATERIALS AND METHOD: Tumour length was assessed in 90 patients undergoing MRI for staging of primary bone tumours with both T1W TSE and OP T1W GrE Dixon MRI sequences at 3 T (n = 42) and 1.5 T (n = 48). Tumour length was measured independently by different observers allowing assessment of inter-observer correlation, and the correlation between measurements on T1W TSE and OP T1W GrE Dixon sequences was also determined. RESULTS: There were 53 males and 37 females (mean age 36.4 years; range 2-77 years). Inter-observer correlation for tumour length on both the T1W TSE and T1W OP GrE Dixon sequences was very good (ICC = 0.94-0.98), and measurement of tumour length comparing T1W TSE and T1W GrE Dixon was also very good (ICC = 0.91-0.99). In 4 cases, tumour length was significantly overestimated on T1W TSE images due to extensive reactive marrow oedema, but more accurately determined on the OP sequence when compared to resection specimens. CONCLUSIONS: The OP T1W GrE Dixon sequence is comparable to T1W TSE for assessment of the intra-medullary length of appendicular bone tumours, and more accurate in the presence of extensive reactive marrow oedema.


Assuntos
Neoplasias Ósseas , Imageamento por Ressonância Magnética , Adolescente , Adulto , Idoso , Medula Óssea , Neoplasias Ósseas/diagnóstico por imagem , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem
3.
Skeletal Radiol ; 44(4): 497-503, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25331354

RESUMO

OBJECTIVES: To assess the diagnostic yield and diagnostic accuracy of image-guided percutaneous needle biopsy of clavicle lesions and to analyse the diagnostic spectrum of clavicular lesions referred to a tertiary musculoskeletal oncology centre. To further describe safe biopsy routes for biopsy of the unique clavicle bone. MATERIALS AND METHODS: A retrospective review of all patients who underwent an image-guided clavicle biopsy during the period from August 2006 to December 2013. A total of 52 patients with 55 consecutive biopsies were identified and included in the study. Image-guided percutaneous biopsy was performed using CT (n = 38) or ultrasound (n = 17). RESULTS: There were 23 males and 29 females, with a mean age of 40 years (range 2 to 87 years). Forty-six of the 55 biopsies (83.6 %) yielded a diagnostic sample and 9 (16.4 %) were non-diagnostic. Thirty of 46 (65.2 %) lesions were malignant and 16 (34.8 %) were benign/non-neoplastic. The most common malignant lesions were metastases, 22 of 30 (73.3 %), followed by primary tumours in 8 of 30 (26.7 %). The most common benign/non-neoplastic lesion was chronic recurrent multifocal osteomyelitis (4 of 16, 25 %) followed by Langerhans cell histiocytosis, epithelioid haemangioma and osteomyelitis (each with 2 of 16, 12.5 %). There was complete agreement between the needle and surgical histology specimen in 12 of 13 subjects (92.3 %). No post-biopsy complications were reported. CONCLUSIONS: Image-guided percutaneous biopsy has high diagnostic yield and accuracy and the described approaches are a safe means of biopsy for clavicle lesions.


Assuntos
Neoplasias Ósseas/diagnóstico , Neoplasias Ósseas/patologia , Clavícula/diagnóstico por imagem , Radiografia Intervencionista , Tomografia Computadorizada por Raios X , Adolescente , Adulto , Idoso , Biópsia por Agulha , Criança , Pré-Escolar , Clavícula/patologia , Feminino , Humanos , Biópsia Guiada por Imagem , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Estudos Retrospectivos , Ultrassonografia de Intervenção , Adulto Jovem
4.
Clin Radiol ; 67(2): 157-64, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-21943720

RESUMO

AIM: To undertake a pilot study assessing whether tumour heterogeneity evaluated using computed tomography texture analysis (CTTA) has the potential to provide a marker of tumour aggression and prognosis in oesophageal cancer. MATERIALS AND METHODS: In 21 patients, unenhanced CT images of the primary oesophageal lesion obtained using positron-emission tomography (PET)-CT examinations underwent CTTA. CTTA was carried out using a software algorithm that selectively filters and extracts textures at different anatomical scales between filter values 1.0 (fine detail) and 2.5 (coarse features) with quantification as entropy and uniformity (measures image heterogeneity). Texture parameters were correlated with average tumour 2-[(18)F]-fluoro-2-deoxy-d-glucose (FDG) uptake [standardized uptake values (SUV(mean) and SUV(max))] and clinical staging as determined by endoscopic ultrasound (nodal involvement) and PET-CT (distant metastases). The relationship between tumour stage, FDG uptake, and texture with survival was assessed using Kaplan-Meier analysis. RESULTS: Tumour heterogeneity correlated with SUV(max) and SUV(mean). The closest correlations were found for SUV(mean) measured as uniformity and entropy with coarse filtration (r=-0.754, p<0.0001; and r=0.748, p=0.0001 respectively). Heterogeneity was also significantly greater in patients with clinical stage III or IV for filter values between 1.0 and 2.0 (maximum difference at filter value 1.5: entropy: p=0.027; uniformity p=0.032). The median (range) survival was 21 (4-34) months. Tumour heterogeneity assessed by CTTA (coarse uniformity) was an independent predictor of survival [odds ratio (OR)=4.45 (95% CI: 1.08, 18.37); p=0.039]. CONCLUSION: CTTA assessment of tumour heterogeneity has the potential to identify oesophageal cancers with adverse biological features and provide a prognostic indicator of survival.


Assuntos
Neoplasias Esofágicas/diagnóstico , Neoplasias Esofágicas/patologia , Tomografia Computadorizada por Raios X , Idoso , Neoplasias Esofágicas/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Projetos Piloto , Tomografia por Emissão de Pósitrons , Estudos Retrospectivos
5.
Eur J Radiol ; 84(1): 123-141, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25445894

RESUMO

Shin pain is a common complaint, particularly in young and active patients, with a wide range of potential diagnoses and resulting implications. We review the natural history and multimodality imaging findings of the more common causes of cortically-based tibial lesions, as well as the rarer pathologies less frequently encountered in a general radiology department.


Assuntos
Doenças Ósseas/diagnóstico , Traumatismos da Perna/diagnóstico , Imagem Multimodal/métodos , Síndrome Pós-Trombótica/diagnóstico , Tíbia/diagnóstico por imagem , Tíbia/patologia , Doenças Ósseas/complicações , Neoplasias Ósseas/complicações , Neoplasias Ósseas/diagnóstico , Feminino , Humanos , Traumatismos da Perna/complicações , Imageamento por Ressonância Magnética/métodos , Dor/etiologia , Síndrome Pós-Trombótica/complicações , Cintilografia , Tomografia Computadorizada por Raios X/métodos
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