Detalhe da pesquisa
1.
Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors.
Proc Natl Acad Sci U S A
; 113(29): 8188-93, 2016 07 19.
Artigo
Inglês
| MEDLINE | ID: mdl-27382179
2.
Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.
Proc Natl Acad Sci U S A
; 111(46): 16274-9, 2014 Nov 18.
Artigo
Inglês
| MEDLINE | ID: mdl-25368144
3.
The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability.
J Biol Chem
; 289(31): 21651-62, 2014 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24936059
4.
Identification through structure-based methods of a bacterial NAD(+)-dependent DNA ligase inhibitor that avoids known resistance mutations.
Bioorg Med Chem Lett
; 24(1): 360-6, 2014 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24287382
5.
Structure-Based Design of Selective Noncovalent CDK12 Inhibitors.
ChemMedChem
; 13(3): 231-235, 2018 02 06.
Artigo
Inglês
| MEDLINE | ID: mdl-29266803
6.
Design, synthesis, and crystal structure of hydroxyethyl secondary amine-based peptidomimetic inhibitors of human beta-secretase.
J Med Chem
; 50(4): 776-81, 2007 Feb 22.
Artigo
Inglês
| MEDLINE | ID: mdl-17300163
7.
Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
J Med Chem
; 60(10): 4386-4402, 2017 05 25.
Artigo
Inglês
| MEDLINE | ID: mdl-28485934
8.
X-ray crystal structure of Staphylococcus aureus FemA.
Structure
; 10(8): 1107-15, 2002 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-12176388
9.
4,5-Disubstituted 6-Aryloxy-1,3-dihydrobenzo[c][1,2]oxaboroles Are Broad-Spectrum Serine ß-Lactamase Inhibitors.
ACS Infect Dis
; 1(7): 310-6, 2015 Jul 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27622821
10.
Correction to Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
J Med Chem
; 60(14): 6459, 2017 07 27.
Artigo
Inglês
| MEDLINE | ID: mdl-28714680
11.
Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1.
Bioorg Med Chem Lett
; 17(12): 3378-83, 2007 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-17434734