Detalhe da pesquisa
1.
Multiomic prediction of therapeutic targets for human diseases associated with protein phase separation.
Proc Natl Acad Sci U S A
; 120(40): e2300215120, 2023 10 03.
Artigo
Inglês
| MEDLINE | ID: mdl-37774095
2.
Applying Artificial Intelligence to Identify Common Targets for Treatment of Asthma, Eczema, and Food Allergy.
Int Arch Allergy Immunol
; 185(2): 99-110, 2024.
Artigo
Inglês
| MEDLINE | ID: mdl-37989115
3.
PandaOmics: An AI-Driven Platform for Therapeutic Target and Biomarker Discovery.
J Chem Inf Model
; 64(10): 3961-3969, 2024 May 27.
Artigo
Inglês
| MEDLINE | ID: mdl-38404138
4.
TNIK's emerging role in cancer, metabolism, and age-related diseases.
Trends Pharmacol Sci
; 45(6): 478-489, 2024 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-38777670
5.
A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models.
Nat Biotechnol
; 2024 Mar 08.
Artigo
Inglês
| MEDLINE | ID: mdl-38459338
6.
AI-powered therapeutic target discovery.
Trends Pharmacol Sci
; 44(9): 561-572, 2023 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-37479540
7.
Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature importance analysis for aging and age-related disease target discovery.
Aging (Albany NY)
; 15(11): 4649-4666, 2023 06 13.
Artigo
Inglês
| MEDLINE | ID: mdl-37315204
8.
Biomedical generative pre-trained based transformer language model for age-related disease target discovery.
Aging (Albany NY)
; 15(18): 9293-9309, 2023 09 22.
Artigo
Inglês
| MEDLINE | ID: mdl-37742294
9.
Identification of dual-purpose therapeutic targets implicated in aging and glioblastoma multiforme using PandaOmics - an AI-enabled biological target discovery platform.
Aging (Albany NY)
; 15(8): 2863-2876, 2023 04 26.
Artigo
Inglês
| MEDLINE | ID: mdl-37100462
10.
A comprehensive AI-driven analysis of large-scale omic datasets reveals novel dual-purpose targets for the treatment of cancer and aging.
Aging Cell
; 22(12): e14017, 2023 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-37888486
11.
AlphaFold accelerates artificial intelligence powered drug discovery: efficient discovery of a novel CDK20 small molecule inhibitor.
Chem Sci
; 14(6): 1443-1452, 2023 Feb 08.
Artigo
Inglês
| MEDLINE | ID: mdl-36794205
12.
High-confidence cancer patient stratification through multiomics investigation of DNA repair disorders.
Cell Death Dis
; 13(11): 999, 2022 11 26.
Artigo
Inglês
| MEDLINE | ID: mdl-36435816
13.
Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine.
Aging (Albany NY)
; 14(6): 2475-2506, 2022 03 29.
Artigo
Inglês
| MEDLINE | ID: mdl-35347083
14.
Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics - An AI-Enabled Biological Target Discovery Platform.
Front Aging Neurosci
; 14: 914017, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35837482
15.
AluScan: a method for genome-wide scanning of sequence and structure variations in the human genome.
BMC Genomics
; 12: 564, 2011 Nov 17.
Artigo
Inglês
| MEDLINE | ID: mdl-22087792
16.
GABRB2 in schizophrenia and bipolar disorder: disease association, gene expression and clinical correlations.
Biochem Soc Trans
; 37(Pt 6): 1415-8, 2009 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-19909288
17.
Leveraging AI to identify dual-purpose aging and disease targets.
Expert Opin Ther Targets
; : 1-4, 2023 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-38038952
18.
GABRB2 association with schizophrenia: commonalities and differences between ethnic groups and clinical subtypes.
Biol Psychiatry
; 61(5): 653-60, 2007 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-16950232
19.
Glioma Association and Balancing Selection of ZFPM2.
PLoS One
; 10(7): e0133003, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26207917
20.
Massive interstitial copy-neutral loss-of-heterozygosity as evidence for cancer being a disease of the DNA-damage response.
BMC Med Genomics
; 8: 42, 2015 Jul 25.
Artigo
Inglês
| MEDLINE | ID: mdl-26208496