RESUMO
Ultrastructural adenohypophysis-thyroid system investigation of Wistar male rats under conditions of chronic poisoning by Linuron herbicide and administration of thymohemin immunomodulator was performed. The release of thyrocyte fragments into the vascular lumen, electron-dense deposits in the area of vascular basal membrane, dilatation of endoplasmic reticulum cisternae as well as inhibition of Golgi complex in thyrocytes are observed in the thyroid exposed to Linuron; in the adenohypophysis under the same conditions swelling and splitting of microvessel basal membrane as well as the increase of biosynthetic and secretory thyrotrophic function can be seen. Thymohemin reduces the degree of degenerative processes in the thyroid gland.
Assuntos
Adjuvantes Imunológicos/uso terapêutico , Linurona/intoxicação , Peptídeos/uso terapêutico , Adeno-Hipófise/efeitos dos fármacos , Hormônios do Timo/uso terapêutico , Glândula Tireoide/efeitos dos fármacos , Animais , Retículo Endoplasmático/efeitos dos fármacos , Retículo Endoplasmático/ultraestrutura , Complexo de Golgi/efeitos dos fármacos , Complexo de Golgi/ultraestrutura , Masculino , Adeno-Hipófise/ultraestrutura , Ratos , Ratos Endogâmicos , Glândula Tireoide/ultraestrutura , Fatores de TempoAssuntos
Ácidos Ftálicos/toxicidade , Poluentes Químicos da Água/toxicidade , Poluentes da Água/toxicidade , Animais , Dose Letal Mediana , Concentração Máxima Permitida , Camundongos , Ácidos Ftálicos/intoxicação , Coelhos , Ratos , Solubilidade , Fatores de Tempo , Poluentes Químicos da Água/intoxicaçãoRESUMO
Dynamic investigation of several immunologic data and complex morphologic study of the thymus of rats fed for a long time (6 months) by very low doses of herbicide simazine have been carried out. Chronic simazine treatment resulted in the development of the secondary immunodeficient state with the damage of T lymphocytes. The morphologic signs of this process were the disarray in thymus structure (dystrophic changes and intercellular contact break of nurse cells, sclerosis of microvessel walls and stromal elements), severe decrease of the T lymphocyte number in peripheral blood, inhibition of phagocytosis reaction of neutrophils.
Assuntos
Síndromes de Imunodeficiência/induzido quimicamente , Simazina/intoxicação , Animais , Técnicas Histológicas , Síndromes de Imunodeficiência/imunologia , Síndromes de Imunodeficiência/patologia , Contagem de Leucócitos , Masculino , Microscopia Eletrônica , Sistema Fagocitário Mononuclear/imunologia , Fagocitose , Ratos , Ratos Endogâmicos , Simazina/administração & dosagem , Linfócitos T/imunologia , Timo/imunologia , Timo/patologiaRESUMO
The authors investigated the effect of long-term use of the herbicide linuron on the histo- and ultrastructure of the thymus and factors of immunological defense. It was found that the use of linuron in animals resulted in development of secondary immunodeficiency states manifested in pathology of the thymic structure, first of all lesions of the epithelial cells-feeders and disorders of immunological indices.
Assuntos
Linurona/toxicidade , Animais , Peso Corporal/efeitos dos fármacos , Imunidade Celular/efeitos dos fármacos , Imunidade Celular/imunologia , Masculino , Microscopia Eletrônica , Tamanho do Órgão/efeitos dos fármacos , Ratos , Ratos Endogâmicos , Timo/efeitos dos fármacos , Timo/imunologia , Timo/patologia , Fatores de TempoRESUMO
State of immunologic and nonspecific resistance of the organism, ultra- and histostructure of the thymus, histopathology of the wall of experimental staph abscess reproduced in animals given low doses of the herbicide simazine for a long time have been studied. It is established that simazine induced the immunodeficiency state underlain by pathologic changes in the thymus. Against this background experimental abscesses developed more rapidly, alterative and exudative processes in their wall proceeding more intensively and proliferative ones--attenuating. This provides prolongation of the abscesses healing phase for an indefinite time and chronization of the process.