RESUMO
Ectopic production of adrenocorticotrophic hormone (ACTH) by malignant neoplasms is a well recognised cause of Cushing's syndrome but is extremely rare in ovarian carcinoma. A patient who underwent surgery for ovarian carcinoma followed by a course of chemotherapy is reported. The tumour was a bilateral moderately differentiated endometrioid adenocarcinoma and contained numerous chromogranin immunoreactive endocrine cells as well as small foci of ACTH immunoreactivity. She subsequently presented with Cushing's syndrome in association with extensive pelvic recurrence of the tumour.
Assuntos
Carcinoma Endometrioide/complicações , Síndrome de Cushing/etiologia , Recidiva Local de Neoplasia/complicações , Neoplasias Ovarianas/complicações , Síndromes Paraneoplásicas/etiologia , Carcinoma Endometrioide/patologia , Feminino , Humanos , Pessoa de Meia-Idade , Neoplasias Ovarianas/patologiaRESUMO
A case of mixed acute leukaemia with T lymphoblastic, myeloblastic, and monocytic components is described. The use of immunological markers, ultrastructural morphology, cytochemistry, immunochemistry, and combined techniques, simultaneously detecting two markers in individual cells, made it possible to define the different blast cell populations.
Assuntos
Leucemia Linfoide/patologia , Leucemia Mieloide Aguda/patologia , Idoso , Anticorpos Monoclonais/imunologia , Feminino , Humanos , Leucemia Linfoide/enzimologia , Leucemia Linfoide/imunologia , Leucemia Mieloide Aguda/enzimologia , Leucemia Mieloide Aguda/imunologia , Microscopia Eletrônica , Peroxidase/metabolismo , Fenótipo , Formação de Roseta , Linfócitos T/ultraestruturaRESUMO
Five patients are described who had repeated endoscopy because of continuing dyspeptic symptoms associated with a negative barium meal. They were found to have multiple recurring gastric erosions (aphthous ulcers). No common aetiological factor could be found, although four of these patients did have a mild or moderatley active superficial chronic gastritis. Conventional peptic ulcer therapy failed to control either symptoms or ulceration. Two patients finally came to gastric surgery (highly selective vagotomy), which resulted in the relief of symptoms and healing of the gastric aphthous ulceration.