Condensed Tannins Improved Immune Functions and Reduced Environmental Pollution of Captive Sichuan Black Goat Kids Under Cadmium Toxicity.

To investigate the effects of condensed tannins (CT) on immune functions and nitrogen (N) emissions of captive Sichuan black goat kids under cadmium (Cd) toxicity, a total of 18 Sichuan black goat kids (2 months old, 9.6 ± 1.2 kg) were randomly used in this 30-day trial. The dietary treatments were (1) CON group, basic diet; (2) Cd group, basic diet + oral 10 mg Cd/kg·BW; and (3) CT group, Cd group + 400 mg/kg CT. Oral Cd supplementation significantly decreased the Cu and Fe contents in serums and livers of captive Sichuan black goat kids (P < 0.05), but adding CT in the Cd group increased the Fe and Mo contents and decreased the Cd content in serums and livers (P < 0.05). Additional CT supplementation in the Cd group extremely increased the activities of serum SOD, GSH-Px, and CAT (P < 0.05), and greatly decreased the serum MDA content (P < 0.05). The CT supplementation in the Cd group also extremely increased the concentrations of serum IgG, IgM, and IgA (P < 0.05), and greatly decreased the contents of IL-6, IL-1ß, and TNF-α in serums (P < 0.05). Adding CT in the Cd group significantly increased the apparent digestibility of CP and EE and decreased the urinary nitrogen (UN) content (P < 0.05, Table 7). In conclusion, the application of additional CT improved antioxidant capacities and immune functions of captive black goats under Cd toxicity, then reduced the oxidative stress and toxic damage of Cd contamination. CT also improved the N digestibility and reduced the N emission, which was helpful to reduce environmental pollution.

Nano-selenium and Macleaya cordata Extracts Improved Immune Function and Reduced Oxidative Damage of Sows and IUGR Piglets After Heat Stress of Sows in Late Gestation.

To investigate the effects of nano-selenium (nano-Se) and Macleaya cordata extracts (MCE) on immune function and oxidative damage of sows and intrauterine growth retardation (IUGR) piglets exposed to heat stress (HS) in large-scale farms, a 2 × 2 factorial design was adopted in this test, and the two factors were nano-Se (0, 0.50 mg/kg) and MCE (0, 500 mg/kg). A total of 80 sows ([Landrace × Yorkshire] × Duroc, parity 2) were used in a 25-day trial from day 90 of gestation to delivery with 20 replications per group and 1 sow per replication. The dietary treatments of sows were as follows: (1) CON group, basic diet (0.30 mg/kg added Se, sodium selenite); (2) Nano-Se group, basic diet (0.00 mg/kg added Se) + 0.50 mg/kg added nano-Se; (3) MCE group, basic diet (0.00 mg/kg added Se) + 500 mg/kg added MCE; and (4) Combined group, basic diet (0.00 mg/kg added Se) + 0.50 mg/kg added nano-Se and 500 mg/kg added MCE. The activities of serum SOD, CAT, and GSH-Px of sows and IUGR piglets were significantly increased in MCE group and combined group, and the MDA content was extremely decreased. There were extreme differences in serum IgG level of sows and IUGR piglets, colostrum, and serum IgM level of IUGR piglets in MCE group and combined group compared with CON group. Maternal combined diets increased greatly the levels of serum IL-10 and IFN-γ of sows and IUGR piglets, and decreased extremely the contents of serum IL-1ß and TNF-α. MCE alone or combination with nano-Se in sow diets decreased greatly mRNA level of Hsp70 and increased mRNA level of Hsp27 in sows and IUGR piglets. In conclusion, nano-Se and/or MCE can be added to sow diets for the amelioration of HS-induced oxidative damage through improving immune function.