Detalhe da pesquisa
1.
Novel antibody-antibiotic conjugate eliminates intracellular S. aureus.
Nature
; 527(7578): 323-8, 2015 Nov 19.
Artigo
Inglês
| MEDLINE | ID: mdl-26536114
2.
High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers.
Bioconjug Chem
; 29(2): 473-485, 2018 02 21.
Artigo
Inglês
| MEDLINE | ID: mdl-29425028
3.
An anti-B7-H4 antibody-drug conjugate for the treatment of breast cancer.
Mol Pharm
; 12(6): 1717-29, 2015 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25853436
4.
Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for THIOMAB™ Drug Conjugates.
Pharm Res
; 32(6): 1884-93, 2015 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-25446772
5.
The cryptophycins as potent payloads for antibody drug conjugates.
Bioorg Med Chem Lett
; 25(4): 864-8, 2015 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25613677
6.
The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma.
J Biol Chem
; 287(29): 24082-91, 2012 Jul 13.
Artigo
Inglês
| MEDLINE | ID: mdl-22613716
7.
Total antibody quantification for MMAE-conjugated antibody-drug conjugates: impact of assay format and reagents.
Bioconjug Chem
; 24(5): 772-9, 2013 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23578050
8.
Characterization of intact antibody-drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography-mass spectrometry.
Anal Biochem
; 412(1): 56-66, 2011 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21216214
9.
Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs.
J Immunol Methods
; 332(1-2): 41-52, 2008 Mar 20.
Artigo
Inglês
| MEDLINE | ID: mdl-18230399
10.
Anti-CD22-MCC-DM1 and MC-MMAF conjugates: impact of assay format on pharmacokinetic parameters determination.
Bioconjug Chem
; 19(8): 1673-83, 2008 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-18637680
11.
An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer.
Mol Cancer Ther
; 17(3): 638-649, 2018 03.
Artigo
Inglês
| MEDLINE | ID: mdl-29282299
12.
Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity.
J Med Chem
; 61(3): 989-1000, 2018 02 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29227683
13.
Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers.
J Med Chem
; 60(23): 9490-9507, 2017 12 14.
Artigo
Inglês
| MEDLINE | ID: mdl-29112410
14.
Disulfide locked variants of factor VIIa with a restricted beta-strand conformation have enhanced enzymatic activity.
Protein Sci
; 14(5): 1171-80, 2005 May.
Artigo
Inglês
| MEDLINE | ID: mdl-15840825
15.
A Novel Anti-CD22 Anthracycline-Based Antibody-Drug Conjugate (ADC) That Overcomes Resistance to Auristatin-Based ADCs.
Clin Cancer Res
; 21(14): 3298-306, 2015 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25840969
16.
Site-specific antibody drug conjugates for cancer therapy.
MAbs
; 6(1): 34-45, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-24423619
17.
Correction: An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer.
Mol Cancer Ther
; 18(11): 2182, 2019 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-31676543
18.
Site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity through linker and antibody engineering.
J Med Chem
; 57(19): 7890-9, 2014 Oct 09.
Artigo
Inglês
| MEDLINE | ID: mdl-25191794
19.
Engineering THIOMABs for site-specific conjugation of thiol-reactive linkers.
Methods Mol Biol
; 1045: 189-203, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23913148
20.
Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates.
Nat Biotechnol
; 30(2): 184-9, 2012 Jan 22.
Artigo
Inglês
| MEDLINE | ID: mdl-22267010