1.
Bioorg Med Chem Lett
; 25(4): 864-8, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25613677
RESUMO
The cryptophycins are a potent class of cytotoxic agents that were evaluated as antibody drug conjugate (ADC) payloads. Free cryptophycin analog 1 displayed cell activity an order of magnitude more potent than approved ADC payloads MMAE and DM1. This potency increase was also reflected in the activity of the cryptophycin ADCs, attached via a either cleavable or non-cleavable linker.