Detalhe da pesquisa
1.
eHydrogenation: Hydrogen-free Electrochemical Hydrogenation.
Angew Chem Int Ed Engl
; 62(38): e202309563, 2023 Sep 18.
Artigo
Inglês
| MEDLINE | ID: mdl-37540528
2.
A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant.
Bioorg Med Chem Lett
; 26(15): 3436-40, 2016 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27374241
3.
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin.
Bioorg Med Chem
; 24(14): 3174-83, 2016 07 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27265687
4.
Rethinking the old antiviral drug moroxydine: Discovery of novel analogues as anti-hepatitis C virus (HCV) agents.
Bioorg Med Chem Lett
; 25(22): 5372-6, 2015 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26428870
5.
Insight into the allosteric inhibition of Abl kinase.
J Chem Inf Model
; 54(5): 1325-38, 2014 May 27.
Artigo
Inglês
| MEDLINE | ID: mdl-24787133
6.
4-Trifluoromethyl bithiazoles as broad-spectrum antimicrobial agents for virus-related bacterial infections or co-infections.
RSC Med Chem
; 15(5): 1589-1600, 2024 May 22.
Artigo
Inglês
| MEDLINE | ID: mdl-38784463
7.
Identification of 4-amino-2-Pyridones as new potent PCSK9 inhibitors: From phenotypic hit discovery to in vivo tolerability.
Eur J Med Chem
; 265: 116063, 2024 Feb 05.
Artigo
Inglês
| MEDLINE | ID: mdl-38160616
8.
Unconventional plasticity of HIV-1 reverse transcriptase: how inhibitors could open a connection "gate" between allosteric and catalytic sites.
J Chem Inf Model
; 53(12): 3117-22, 2013 Dec 23.
Artigo
Inglês
| MEDLINE | ID: mdl-24256065
9.
Nucleoside Derivatives of 2,6-Diaminopurine Antivirals: Base-Modified Nucleosides with Broad-Spectrum Antimicrobial Properties.
ChemMedChem
; 18(16): e202300200, 2023 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37221137
10.
Probing the effects of MR120 in preclinical chronic colitis: A first-in-class anti-IBD agent targeting the CCL20/CCR6 axis.
Eur J Pharmacol
; 945: 175613, 2023 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36841282
11.
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors.
Bioorg Med Chem Lett
; 22(5): 2094-8, 2012 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22300661
12.
A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: from in silico screening to cyclodextrin formulation.
Bioorg Med Chem Lett
; 22(17): 5579-83, 2012 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22853993
13.
Towards Innovative Antibacterial Correctors for Cystic Fibrosis Targeting the Lung Microbiome with a Multifunctional Effect.
ChemMedChem
; 17(17): e202200277, 2022 09 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35638249
14.
Discovery of small-molecules targeting the CCL20/CCR6 axis as first-in-class inhibitors for inflammatory bowel diseases.
Eur J Med Chem
; 243: 114703, 2022 Dec 05.
Artigo
Inglês
| MEDLINE | ID: mdl-36067700
15.
Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells.
Bioorg Med Chem Lett
; 21(19): 5928-33, 2011 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21856155
16.
Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3σ case.
Bioorg Med Chem Lett
; 21(22): 6867-71, 2011 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21962576
17.
Biologically driven synthesis of pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors: an old scaffold as a new tool for medicinal chemistry and chemical biology studies.
Chem Rev
; 114(14): 7189-238, 2014 Jul 23.
Artigo
Inglês
| MEDLINE | ID: mdl-24873489
18.
System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2.
Eur J Med Chem
; 224: 113683, 2021 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-34273661
19.
Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIIIß) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus, and Human Rhinoviruses.
ChemMedChem
; 16(23): 3548-3552, 2021 12 06.
Artigo
Inglês
| MEDLINE | ID: mdl-34382337
20.
Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms.
Bioorg Med Chem
; 18(11): 3999-4008, 2010 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20451394