Detalhe da pesquisa
1.
Medicinal Polypharmacology in the Clinic - Translating the Polypharmacolome into Therapeutic Benefit.
Pharm Res
; 41(3): 411-417, 2024 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-38366233
2.
Target repurposing unravels avermectins and derivatives as novel antibiotics inhibiting energy-coupling factor transporters (ECFTs).
Arch Pharm (Weinheim)
; : e2400267, 2024 Jun 19.
Artigo
Inglês
| MEDLINE | ID: mdl-38896404
3.
Medicinal polypharmacology: Exploration and exploitation of the polypharmacolome in modern drug development.
Drug Dev Res
; 85(1): e22125, 2024 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-37920929
4.
Stereoselective Inhibition of High- and Low-Affinity Organic Cation Transporters.
Mol Pharm
; 20(12): 6289-6300, 2023 Dec 04.
Artigo
Inglês
| MEDLINE | ID: mdl-37962560
5.
A Novel Huntington's Disease Assessment Platform to Support Future Drug Discovery and Development.
Int J Mol Sci
; 23(23)2022 Nov 25.
Artigo
Inglês
| MEDLINE | ID: mdl-36499090
6.
Unraveling binding mechanism and kinetics of macrocyclic Gαq protein inhibitors.
Pharmacol Res
; 173: 105880, 2021 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34506902
7.
Adenine-(methoxy)-ethoxy-Pα,α-dithio-triphosphate inhibits pathologic calcium pyrophosphate deposition in osteoarthritic human chondrocytes.
Org Biomol Chem
; 17(46): 9913-9923, 2019 11 27.
Artigo
Inglês
| MEDLINE | ID: mdl-31720670
8.
Synthesis, characterization, and in vitro evaluation of the selective P2Y2 receptor antagonist AR-C118925.
Purinergic Signal
; 13(1): 89-103, 2017 03.
Artigo
Inglês
| MEDLINE | ID: mdl-27766552
9.
8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors.
Bioorg Med Chem
; 24(21): 5462-5480, 2016 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27658798
10.
Stereoselectivity in Cell Uptake by SLC22 Organic Cation Transporters 1, 2, and 3.
J Med Chem
; 66(23): 15990-16001, 2023 12 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38052451
11.
Stereoselectivity in the Membrane Transport of Phenylethylamine Derivatives by Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3.
Biomolecules
; 12(10)2022 Oct 18.
Artigo
Inglês
| MEDLINE | ID: mdl-36291716
12.
Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2.
Biochem Pharmacol
; 197: 114871, 2022 03.
Artigo
Inglês
| MEDLINE | ID: mdl-34902340
13.
Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients.
Front Pharmacol
; 12: 688950, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34093211
14.
Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin.
Cell Chem Biol
; 28(12): 1750-1757.e5, 2021 12 16.
Artigo
Inglês
| MEDLINE | ID: mdl-33725479
15.
Cellular Uptake of Psychostimulants - Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers?
Front Pharmacol
; 11: 609811, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-33551812
16.
Stereoselective cell uptake of adrenergic agonists and antagonists by organic cation transporters.
Biochem Pharmacol
; 171: 113731, 2020 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31783011
17.
Ligand binding and activation of UTP-activated G protein-coupled P2Y2 and P2Y4 receptors elucidated by mutagenesis, pharmacological and computational studies.
Biochim Biophys Acta Gen Subj
; 1864(3): 129501, 2020 03.
Artigo
Inglês
| MEDLINE | ID: mdl-31812541
18.
Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors.
Br J Pharmacol
; 177(8): 1898-1916, 2020 04.
Artigo
Inglês
| MEDLINE | ID: mdl-31881095
19.
The big data challenge - and how polypharmacology supports the translation from pre-clinical research into clinical use against neurodegenerative diseases and beyond.
Neural Regen Res
; 19(8): 1647-1648, 2024 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-38103223
20.
Highly Variable Pharmacokinetics of Tyramine in Humans and Polymorphisms in OCT1, CYP2D6, and MAO-A.
Front Pharmacol
; 10: 1297, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-31736764