Detalhe da pesquisa
1.
Potent, selective and orally bioavailable leucine-rich repeat kinase 2 (LRRK2) inhibitors.
Bioorg Med Chem Lett
; 26(11): 2631-5, 2016 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27106707
2.
Attenuation of scratch-induced reactive astrogliosis by novel EphA4 kinase inhibitors.
J Neurochem
; 118(6): 1016-31, 2011 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-21736568
3.
Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitors.
Bioorg Med Chem Lett
; 20(5): 1779-82, 2010 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20122828
4.
SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition.
Bioorg Med Chem Lett
; 20(6): 1885-9, 2010 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20176482
5.
First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.
J Pharmacol Exp Ther
; 328(1): 131-40, 2009 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-18854490
6.
A conformational constraint improves a beta-secretase inhibitor but for an unexpected reason.
Bioorg Med Chem Lett
; 19(17): 4993-5, 2009 Sep 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19640712
7.
Discovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1.
Bioorg Med Chem Lett
; 19(11): 2977-80, 2009 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19409780
8.
Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1).
J Med Chem
; 49(25): 7270-3, 2006 Dec 14.
Artigo
Inglês
| MEDLINE | ID: mdl-17149856
9.
Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).
J Med Chem
; 47(26): 6447-50, 2004 Dec 16.
Artigo
Inglês
| MEDLINE | ID: mdl-15588077
10.
Asymmetric syntheses of pectenotoxins-4 and -8, part I: synthesis of the C1-C19 subunit.
Angew Chem Int Ed Engl
; 41(23): 4569-73, 2002 Dec 02.
Artigo
Inglês
| MEDLINE | ID: mdl-12458541
11.
Asymmetric syntheses of pectenotoxins-4 and -8, part II: synthesis of the C20-C30 and C31-C40 subunits and fragment assembly.
Angew Chem Int Ed Engl
; 41(23): 4573-6, 2002 Dec 02.
Artigo
Inglês
| MEDLINE | ID: mdl-12458542
12.
Small molecule inhibitors of the XIAP protein-protein interaction.
Curr Top Med Chem
; 7(10): 966-71, 2007.
Artigo
Inglês
| MEDLINE | ID: mdl-17508928
13.
Beta-secretase (BACE-1) inhibitors: accounting for 10s loop flexibility using rigid active sites.
Bioorg Med Chem Lett
; 17(4): 1117-21, 2007 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-17112725
14.
Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors.
Bioorg Med Chem Lett
; 17(21): 5831-5, 2007 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17827011
15.
Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.
Bioorg Med Chem Lett
; 17(14): 4057-61, 2007 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-17482814
16.
Strategies towards improving the pharmacokinetic profile of ε-substituted lysinol-derived HIV protease inhibitors.
ChemMedChem
; 6(2): 253-7, 2011 Feb 07.
Artigo
Inglês
| MEDLINE | ID: mdl-21275047
17.
Evolution of tertiary carbinamine BACE-1 inhibitors: Abeta reduction in rhesus CSF upon oral dosing.
ChemMedChem
; 4(1): 37-40, 2009 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-19085994