1.
Bioorg Med Chem Lett
; 20(18): 5443-8, 2010 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20724156
RESUMO
Melanin concentrating hormone (MCH) is an important mediator of energy homeostasis and plays role in several disorders such as obesity, stress, depression and anxiety. The synthesis and biological evaluation of novel benzimidazole derivatives as MCHR1 antagonists are described. The in vivo proof of principle for weight loss with a lead compound from this series is exemplified.