Bis(µ-Tartrato)Di(µ-Hydroxy) Germanate (IV) Triethanolammonium as a Mononuclear Alkaline Phospholipase A2 Inhibitor.

It was established that the administration of an aqueous solution of bis(µ-tartrato)di(µ-hydroxy) germanate (IV) triethanolammonium to animals daily for 2 months at a dose of the active substance of 10 mg/kg of the animal's weight leads to inhibition of the total activity of the alkaline phospholipase A2 of mononuclear cells. The results of the study can be used to correct lipid metabolism in the development of disorders in hyperlipidemia. This makes it possible to expand the scope of use of the studied substance and create new pharmaceuticals based on bis(µ-tartrato)di(µ-hydroxy) germanate (IV) triethanolammonium prevent and inhibit the development of hyperlipidemia.

[Antibiotic Resistance of Microbial Isolates from Long-Term Healing Wounds Exposed to Light of Various Wave Lengths].

The data on inhibition of the growth of microorganisms of a characteristic spectrum and antibiotic resistance isolated from long-term healing wounds by light of various wave ranges are presented. The growing cultures on blood agar were exposed to polarized light, red and infrared, ultraviolet of medium- and short-wave continuous modes accustomed in physiotherapy of wounds.The effect of light in some way induced inhibition of the growth, but complete recovery was stated only after the use of ultraviolet light when confirmed quantitatively in terms of the CFU.

[Molecular imprinted polymers for macrolides, aminoglycosides and some other biosynthetic antibiotics].

Molecular imprinted polymers (MIP) for macrolides, aminoglycosides and some other biosynthetic antibiotics described in the literature were analysed with a purpose of evaluating their possible use for the antibiotics sorption.

[Molecular imprinted polymers for penicillins and tetracyclines].

The molecular imprinted polymers (MIPs) for penicillins and tetracyclines described in the literature were analysed with a purpose of evaluating their possible use for the antibiotic sorption isolation.

Iron-containing proteins lactoferrin and ferritin in biological media of patients with pulmonary tuberculosis.

Salivary and serum levels of lactoferrin and ferritin were measured in patients with pulmonary tuberculosis and patients with other nonspecific respiratory diseases. Measurements of lactoferrin in biological media and particularly in the serum of patients with pulmonary tuberculosis proved to be a highly informative test for monitoring the disease course, i.e. for evaluation of inflammatory process activity. Ferritin level can serve as an indicator of tissue destruction during inflammation and of the course of rehabilitation processes.

[Sensitivity of the reproductive organs to hormones in hypobaric hypoxia].

Antihypoxic activity of oxytocin and feasibility of its use as an antihypoxic agent are shown. ACTH and vasopressin have an opposite action. Female rat castration leads to enhancement of FSH and LH activity of the hypophysis. Hypoxia does not influence gonadotrophic activity of castrate and cycling animals. Chronic hypobaric hypoxia depresses myometrial contractility in intact sensitivity to oxytocin. Sensitivity of the ovaries to exogenic FSH and ovarian secretory function decline. Hypoxia has no effect on sensitivity of vaginal epithelium to folliculin, but raises uterine sensitivity to adrenaline.

The effects of oxytocin on the activity of cells in the anterior hypothalamus in experimental stress.

Acute experiments on white laboratory rats were performed to study spike activity in neurons of the anterior hypothalamus in response to i.v. injections of different doses of oxytocin. The results showed that oxytocin evoked different types of rearrangement of neuron activity both in intact and in stressed animals. The dose-related effects of oxytocin affected the latent periods of neuron responses and the nature of rearrangements in spike activity. The greater the frequency of the baseline activity of the cells, the less marked was the response of the neurons to administration of oxytocin.

[Effect of oxytocin on the activity of neurons in posterior hypothalamic regions of stressed rats].

The dynamics of pulse activity in the cells of posterior hypothalamic regions was studied in acute experiments on white rats treated with oxytocin. Intravenous injections of the drug induced dose-dependent reorganization of the neuron discharge both in intact rats and in animals with obvious emotional sexual stress. The dose-dependent effect was observed in various latent periods of the neuron response and was manifested by changes in the character of pulsation. The higher the background frequency of cell pulses, the less pronounced was the neuron response to the drug. In some cases, the drug intensified the burst activity and produced regulation of the discharge rhythm.

[Long-term group isolation is a factor of dysregulation of reproductive function in rats].

In the condition of prolonged group sex starvation of rats variations were seen in behavioral reactions, fertility, extent of weight gain, litter, blood alpha-tocopherol level, eosinophil count, lipid peroxidation, evoked brain potentials. All these processes are the sign of stress development in rats. Thus, stress in mature rats influences litter and fertility, newborn rats had underdeveloped nervous system. Changes in the activity of endogenic antioxidant system in this experiment are discussed.

[Sexual conflict situation in the rat--model of emotional stress]. / Polovaia konfliktnaia situatsiia u krys--model' émotsional'nogo stressa.

It has been shown on female Wistar rats, that as a result of three months sexual deprivation, in a cage of special construction, they may develop an emotional stress leading to a change in mobility and to a discordance in the functional system maintaining the optimal level of sexual hormones in their organism. A design has been presented of a cage for creating a sexual conflict situation, which is a new model of emotional stress.

[Dynamics of spontaneous activity of hypothalamic neurons in the rat during emotional stress]. / Dinamika spontannoi aktivnosti neironov gipotalamusa u krys pri émotsional'nom stresse.

Statistic parametres of discharges of separate cells in various hypothalamic nuclei were studied on Wistar rats in acute experiment under aethernembutal anesthesia. By logarithmic transformation of activity parameters a difference was established and some similar features of background firing of neurones in the frontal and posterior zones of the hypothalamus. Changes were shown in quantitative characteristics of impulse activity of hypothalamic neurones during development of emotional stress in conditions of long-term sexual conflict situations.

[Effect of oxytocin on the activity of posterior hypothalamic neurons in the rat]. / Vliianie oksitotsina na aktivnost' neironov zadnego gipotalamusa u krys.

Changes of unit activity in different nuclei of the posterior hypothalamus induced by intravenous oxytocin injections were studied in acute experiments on Wistar rats anaesthetized with nembutal. Influence of nonapeptide was dose-dependent. Latencies of various neuronal reactions were different. Mechanisms of oxytocin regulation of neuronal activity in the posterior hypothalamus are discussed.

[The interaction of pressor and depressor mechanisms in the autoregulation of arterial pressure]. / O vzaimodeistvii pressornykh i depressornykh mekhanizmov v samoreguliatsii arterial'nogo davleniia

In normal conditions, the threshold depressor effects of the aortal nerve were shown to be stronger than its threshold pressor effects during stimulation of both the hypothalamic pressor points and the pressor areas of the bulbar vaso-motor center. Mono- and polymodal neurons as related to excitation of pressor areas of the posterior hypothalamus and the aortal deressor nerve were revealed in a number of structures of the medulla oblongata cardio-vascular center. The convergent neurons are supposed to determine the output of antagonistic pressor and depressor interrelationships at the level of the medulla oblongata neurons.

[Characteristics of neurophysiologic changes in experimental stress induced by long-term group isolation in rats]. / Osobennosti neirofiziologicheskikh izmenenii pri éksperimental'nom stresse, vyzvannom dlitel'noi gruppovoi izoliatsiei u krys.

Long-term sexual conflict situation induced changes in main statistical parameters of firing rate in the hippocampus, amygdala and septum both in intact rats and in those under stress. The latter were shown to reveal an increased number of the neurons with polymodal distribution of interspike intervals in all the structures under study.

[Neurophysiological analysis of the action of piracetam on the hippocampal neurons in rabbits]. / Neirofiziologicheskii analiz deistviia piratsetama na neirony gippokampa krolikov.

The unit activity in the hippocampus formation under the effect of pyracetam was found to depend on the latter dose in rabbits. The ligand-receptor interrelationship with pyracetam seems to exist at the level of the hippocampus formation.

[Effect of methyluracil on lipid peroxidation in the plasma and tissue homogenates from ulcer lesions of the gastric wall in rats]. / Vliianie metiluratsila na perekisnoe okislenie lipidov v plazme krovi i gomogenatakh tkanei iazvennogo defekta stenki zheludka krys.

Dynamics of experimental acetate gastric ulcer healing and lipid peroxidation were studied in rat blood and gastric tissues after treatment with methyluracil. The drug was shown to stimulate reparation and to inhibit lipid peroxidation. The antiulcerogenous effects of methyluracil appear to involve the antioxidative mechanisms.

[1-Ethoxysilatrane: ulcerostatic effect and its possible mechanisms]. / 1-Etoksisilatran: ul'tserostaticheskii éffekt i ego vozmozhnye mekhanizmy.

Stimulating effect of I-ethoxy silatrane on healing of acetate derived stomach ulcer was studied in rats. The drug was shown to inhibit lipid peroxidation and free-radical oxidation in blood and gastric tissues as well as to accelerate reparation in ulcerous zone. I-Ethoxy silatrane interacted with artificial membranes and affected the respiration rate in liver mitochondria. Membranetropic effect of I-ethoxy silatrane appears to be involved in the drug ulcerostatic effect.

[Krezatsin--a stimulant of the activity of regenerating liver cells]. / Krezatsin--stimuliator aktivnosti regeneriruiushchikh kletok pecheni.

In experiments with partial hepatectomy in rats, the application of cresacin was shown to potentiate processes of hepatocyte regeneration, to increase high-energy compounds therein, and to accelerate some phases of mitotic cycle. These processes occur along with an inhibition of lipid peroxidation in hepatocytes, a decrease in the rate of transmembrane oxygen transport in mitochondria, and a reduction of cytochrome oxidase amount. It was concluded that cresacin directly stimulates diverse links of metabolic pathway.

[Clinical, diagnostic and therapeutic features of tricuspid infectious endocarditis]. / Osobennosti kliniki, diagnostiki i lecheniia infektsionnogo éndokardita trikuspidal'nogo klapana.

From 1987 to 1998, examination and treatment were conducted of 12 patients with infectious endocarditis of the tricuspid valve (TIE). 11 of them were operated. TIE was clinically characterized by lesser circulation thromboembolism and marked right ventricular failure. TIE was successfully diagnosed by echo-CG (diagnostic sensitivity 83.3%). Serious disturbances of cellular immunity demanded immunocorrection. Indications for surgical treatment are listed.