Characterisation of infections in patients with acute myeloid leukaemia receiving venetoclax and a hypomethylating agent.

We investigated the incidence of invasive fungal infections (IFIs) and other infectious complications in patients receiving venetoclax and hypomethylating agent therapy for acute myeloid leukaemia (AML). This retrospective, multicentre cohort study included adult patients with AML who received at least one cycle of venetoclax and either azacitidine or decitabine between January 2016 and August 2020. The primary outcome was the incidence of probable or confirmed IFI. Secondary outcomes included antifungal prophylaxis prescribing patterns, incidence of bacterial infections, and incidence of neutropenic fever hospital admissions. Among 235 patients, the incidence of probable or confirmed IFI was 5.1%. IFI incidence did not differ significantly according to age, antifungal prophylaxis use, or disease status. In the subgroup of patients with probable or confirmed IFIs, six (50%) were receiving antifungal prophylaxis at the time of infection. The overall incidence of developing at least one bacterial infection was 33.6% and 127 (54%) patients had at least one hospital admission for febrile neutropenia. This study demonstrated an overall low risk of developing probable or confirmed IFI as well as a notable percentage of documented bacterial infections and hospital admissions due to neutropenic fever.

Roadmap to resilience: Incorporating a wellness program into the pharmacy residency curriculum.

BACKGROUND AND PURPOSE: In recent years, wellness initiatives across various health professions have prompted national pharmacy organizations to prioritize pharmacist well-being. Pharmacy residency programs present ideal platforms to foster wellness practices among new pharmacy practitioners. By describing the components and implementation of the Resident Wellness Program at an academic medical center, we aim to guide other institutions in facilitating wellness activities for pharmacy trainees. EDUCATIONAL ACTIVITY AND SETTING: The Resident Wellness Program was implemented in 2019 and provides pharmacy residents with a structured framework of wellness activities intended to promote mental and physical health and prevent burnout. Feedback surveys and written reflections have provided initial evidence of the program's value in enhancing resident well-being. FINDINGS: A qualitative analysis of surveys and reflections highlights the program's positive impact, with more than 90% of participants indicating that the program met their needs and promoted self-development. Perspectives from residents and administrators identified key strengths, including the structured nature of sessions and diversity of wellness topics. Opportunities for improvement include teaching participants to apply practical wellness strategies and refining topics to align with residents' interests. As the program evolves, a formal analysis via standardized surveys and an assessment of longitudinal impact will support continued enhancement. SUMMARY: The implementation of a pharmacy resident wellness program provides an opportunity to promote well-being and work performance. By engaging in similar initiatives, other institutions can mirror the commitment of national pharmacy organizations and contribute to a culture of wellness among pharmacy residents and the greater pharmacy workforce.