Detalhe da pesquisa
1.
Autophagosome precursor maturation requires homotypic fusion.
Cell
; 146(2): 303-17, 2011 Jul 22.
Artigo
Inglês
| MEDLINE | ID: mdl-21784250
2.
Regulation of mammalian autophagy in physiology and pathophysiology.
Physiol Rev
; 90(4): 1383-435, 2010 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-20959619
3.
IGF-1 receptor antagonism inhibits autophagy.
Hum Mol Genet
; 22(22): 4528-44, 2013 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23804751
4.
Dynein mutations impair autophagic clearance of aggregate-prone proteins.
Nat Genet
; 37(7): 771-6, 2005 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-15980862
5.
Broad proteomics analysis of seeding-induced aggregation of α-synuclein in M83 neurons reveals remodeling of proteostasis mechanisms that might contribute to Parkinson's disease pathogenesis.
Mol Brain
; 17(1): 26, 2024 May 22.
Artigo
Inglês
| MEDLINE | ID: mdl-38778381
6.
Establishment of a high-content imaging assay for tau aggregation in hiPSC-derived neurons differentiated from two protocols to routinely evaluate compounds and genetic perturbations.
SLAS Discov
; 29(2): 100137, 2024 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-38128829
7.
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.
Nat Genet
; 36(6): 585-95, 2004 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-15146184
8.
Pharmacological mTOR-inhibition facilitates clearance of AD-related tau aggregates in the mouse brain.
Eur J Pharmacol
; 934: 175301, 2022 Nov 05.
Artigo
Inglês
| MEDLINE | ID: mdl-36191631
9.
Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer's disease model.
Sci Rep
; 11(1): 2879, 2021 02 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33536571
10.
Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.
Nat Neurosci
; 9(6): 824-31, 2006 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-16699508
11.
Clearance of mutant aggregate-prone proteins by autophagy.
Methods Mol Biol
; 445: 195-211, 2008.
Artigo
Inglês
| MEDLINE | ID: mdl-18425452
12.
Role of autophagy in the clearance of mutant huntingtin: a step towards therapy?
Mol Aspects Med
; 27(5-6): 520-7, 2006.
Artigo
Inglês
| MEDLINE | ID: mdl-16973207
13.
Differential efficacy of the TSPO ligands etifoxine and XBD-173 in two rodent models of Multiple Sclerosis.
Neuropharmacology
; 108: 229-37, 2016 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27039042
14.
Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy.
Nat Commun
; 6: 8045, 2015 Aug 20.
Artigo
Inglês
| MEDLINE | ID: mdl-26289944
15.
Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases.
Int J Biochem Cell Biol
; 36(12): 2541-50, 2004 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-15325591
16.
Can autophagy protect against neurodegeneration caused by aggregate-prone proteins?
Neuroreport
; 15(16): 2443-5, 2004 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-15538170
17.
Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D.
J Cell Biol
; 196(4): 483-96, 2012 Feb 20.
Artigo
Inglês
| MEDLINE | ID: mdl-22351926
18.
Plasma membrane helps autophagosomes grow.
Autophagy
; 6(8): 1184-6, 2010 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-20861674
19.
Plasma membrane contributes to the formation of pre-autophagosomal structures.
Nat Cell Biol
; 12(8): 747-57, 2010 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-20639872
20.
α-Synuclein impairs macroautophagy: implications for Parkinson's disease.
J Cell Biol
; 190(6): 1023-37, 2010 Sep 20.
Artigo
Inglês
| MEDLINE | ID: mdl-20855506