RESUMO
This research studied the preferences reported by women and men about their Ideal Body Image for the Opposite Sex (IBIOS), and its association with body mass index (BMI). It also analysed the preferences of each sex for a woman's ideal body image (W-IBI) and a man's ideal body image (M-IBI). A total of 450 participants aged 18-70 years with different weights were studied. Their IBIOS was assessed using standard figural stimuli. The sample was divided in four groups by sex and age (<45 years; ≥45 years). Sex and age differences in IBIOS, as well as sex differences in the preferences for a woman's ideal body image (W-IBI) and a man's ideal body image (M-IBI), were tested using a non-parametric Mann-Whitney U test. The association between IBIOS and BMI was analysed using Spearman's correlation. In all groups, the most chosen silhouette as IBIOS was number 4. In the under-45 years group, women chose bigger silhouettes for the opposite sex than men did (p<0.05). In this age group women chose as ideal smaller silhouettes for the female body than men did (p<0.01). In addition, women and men in the younger age group and with normal weight chose smaller silhouettes, while those who were overweight or obese selected larger silhouettes (p<0.001). Age was found to be a relevant factor in IBIOS preferences, and in the association between IBIOS and nutritional status as measured by BMI, which was only observed to be significant in the younger age group.
Assuntos
Imagem Corporal , Sobrepeso , Feminino , Humanos , Masculino , Recém-Nascido , Índice de Massa Corporal , Obesidade , Caracteres Sexuais , Peso CorporalRESUMO
OBJECTIVE: To evaluate diets in terms of nutritional characteristics and quality from the perspectives of health, greenhouse gas emissions (GHGE) and possible associations with each other in a representative sample of students at a public university. DESIGN: Cross-sectional. Dietary intake was evaluated with a validated FFQ, and diet quality was assessed through the Healthy Eating Index (HEI-2010) and MedDietScore (MDS). GHGE data were obtained from the literature. In addition, sex, socio-economic status (SES) and body fat (BF) status were analysed as covariates. SETTING: Basque Autonomous Community, Spain. PARTICIPANTS: Totally, 26 165 healthy adults aged 18-28 years. RESULTS: Student diets were characterised by low consumption of carbohydrates (38·72 % of total energy intake (TEI)) and a high intake of lipids (39·08 % of TEI). Over half of the participants had low dietary quality. The low-emitting diets were more likely to be consumed by subjects with low HEI-2010 scores (ß: 0·039 kg eCO2/1000 kcal/d) and high MDS scores (ß: -0·023 kg eCO2/1000 kcal/d), after controlling for sex, SES and BF status. Both the low-emitting and healthy diets were more likely to be consumed by women and by those with normal BF percentage. CONCLUSIONS: UPV/EHU university students' diets were characterised by moderate quality from a nutritional perspective and moderate variation in the size of carbon footprints. In this population, diets of the highest quality were not always those with the lowest diet-related GHGE; this relationship depended in part on the constructs and scoring criteria of diet quality indices used.
Assuntos
Pegada de Carbono , Dieta , Adolescente , Adulto , Estudos Transversais , Ingestão de Energia , Feminino , Humanos , Inquéritos Nutricionais , Valor Nutritivo , Estudantes , Universidades , Adulto JovemRESUMO
The Roma population is the largest transnational ethnic minority in Europe, characterized by a linguistic, cultural and historical heterogeneity. Comparative linguistics and genetic studies have placed the origin of European Roma in the Northwest of India. After their migration across Persia, they entered into the Balkan Peninsula, from where they spread into Europe, arriving in the Iberian Peninsula in the 15th century. Their particular demographic history has genetic implications linked to rare and common diseases. However, the South Asian source of the proto-Roma remains still untargeted and the West Eurasian Roma component has not been yet deeply characterized. Here, in order to describe both the South Asian and West Eurasian ancestries, we analyze previously published genome-wide data of 152 European Roma and 34 new Iberian Roma samples at a fine-scale and haplotype-based level, with special focus on the Iberian Roma genetic substructure. Our results suggest that the putative origin of the proto-Roma involves a Punjabi group with low levels of West Eurasian ancestry. In addition, we have identified a complex West Eurasian component (around 65%) in the Roma, as a result of the admixture events occurred with non-proto-Roma populations between 1270-1580. Particularly, we have detected the Balkan genetic footprint in all European Roma, and the Baltic and Iberian components in the Northern and Western Roma groups, respectively. Finally, our results show genetic substructure within the Iberian Roma, with different levels of West Eurasian admixture, as a result of the complex historical events occurred in the Peninsula.
Assuntos
Etnicidade/genética , Roma (Grupo Étnico)/genética , Povo Asiático/genética , Efeito Fundador , Fluxo Gênico/genética , Variação Genética/genética , Genética Populacional , Haplótipos/genética , Migração Humana , Humanos , Grupos Minoritários , População Branca/genéticaRESUMO
Comparing twins from same- and opposite-sex pairs can provide information on potential sex differences in a variety of outcomes, including socioeconomic-related outcomes such as educational attainment. It has been suggested that this design can be applied to examine the putative role of intrauterine exposure to testosterone for educational attainment, but the evidence is still disputed. Thus, we established an international database of twin data from 11 countries with 88,290 individual dizygotic twins born over 100 years and tested for differences between twins from same- and opposite-sex dizygotic pairs in educational attainment. Effect sizes with 95% confidence intervals (CI) were estimated by linear regression models after adjusting for birth year and twin study cohort. In contrast to the hypothesis, no difference was found in women (ß = -0.05 educational years, 95% CI -0.11, 0.02). However, men with a same-sex co-twin were slightly more educated than men having an opposite-sex co-twin (ß = 0.14 educational years, 95% CI 0.07, 0.21). No consistent differences in effect sizes were found between individual twin study cohorts representing Europe, the USA, and Australia or over the cohorts born during the 20th century, during which period the sex differences in education reversed favoring women in the latest birth cohorts. Further, no interaction was found with maternal or paternal education. Our results contradict the hypothesis that there would be differences in the intrauterine testosterone levels between same-sex and opposite-sex female twins affecting education. Our findings in men may point to social dynamics within same-sex twin pairs that may benefit men in their educational careers.
Assuntos
Testosterona , Gêmeos Dizigóticos , Estudos de Coortes , Escolaridade , Feminino , Humanos , Masculino , Caracteres SexuaisRESUMO
BACKGROUND: African Pygmy Populations (APP) are believed to be one of the first groups of the Congo Basin rainforest peoples to separate from the rest of modern humanity. The arrival of Bantu speaking agriculturalists from 5,000 BP led to the formation of a large number of ethnic complexes in Central Africa and the Atlantic coastal area, mainly due to a one-way flow of pygmy women. There are now only a few small contingents of African Pygmy population groups who are mixed or who have almost disappeared as a result of migratory flows from Cameroon. AIMS: We analysed the adult phenotypic diversity of 9 populations (17 groups of both sexes) of the Congo basin and Bioko Island, which were anthropometrically characterised in 1948. The phenotypic clusters that we detected, which we interpret as likely mixing of local Pygmy populations and Bantus, may be useful as references for future studies, particularly genetics. SUBJECTS AND METHODS: The matrix of inter-distances between populations was generated, using the 21 variables, with the Euclidean distance between the mean vectors relating to the standardised variables. When the UPGMA (Unweighted Pair Group Method with Arithmetic Mean) was used separately in men and women, the phylogenetic trees showed a clear separation between populations. RESULTS: The body measurements that most effectively distinguished the groups are linear dimensions and the width of the hips and mean thoracic circumference. In this study, the cephalo-facial dimensions were of little value in identifying the groups. CONCLUSIONS: The samples of Equatorial Guinea show a major inter-group overlap, and considerable intra-group variations. There are also notable differences amongst African Pygmy populations in terms of height, but not in body proportions.
Assuntos
População Negra/estatística & dados numéricos , Etnicidade/estatística & dados numéricos , Fenótipo , África Central , Guiné Equatorial , Feminino , Humanos , Masculino , FilogeniaRESUMO
The aim of this research was to analyse variation in body image perception and satisfaction by age, sex and nutritional status in an adult sample from the Basque Country, Spain. A case-control study was performed for 227 women and 178 men aged 18-70 years. Stunkard's silhouettes were used to evaluate Current Body Image (CBI) and Ideal Body Image (IBI), as well as dissatisfaction and inconsistency scores. Nutritional status was assessed following the WHO criteria for BMI in an adult population. The sample was divided into four groups based on sex and age (early adulthood <45 years, and middle/older adulthood ≥45 years). The Mann-Whitney U test was employed to evaluate sex and age differences, and the Gamma coefficient to assess the association between body image variables and nutritional status. Significant age differences in CBI (p<0.05) and sex differences in IBI (p<0.001) were detected. Both variables showed a positive association with BMI (p<0.01), which indicates that BMI is a biological characteristic related to body image satisfaction and influences participants' perception of themselves. Dissatisfaction scores showed that both sex and age differences (p<0.05) were negatively associated with BMI (p<0.001). Only participants ≥45 years presented sex differences in inconsistency scores (p<0.05); this variable was associated with BMI in women (p<0.01). Preferences in body image showed sexual dimorphism, with women preferring thinner bodies than men - a pattern observed in many Western populations - linked in part to sociocultural pressures. Women were more dissatisfied with their bodies than men; a higher dissatisfaction was observed in older relative to younger participants. The results confirm the association between nutritional status and body size perception and satisfaction, but also the relationship between nutritional status and the reliability with which women can classify themselves; in men, this relationship was not as clear.
Assuntos
Imagem Corporal , Tamanho Corporal , Estado Nutricional , Obesidade/psicologia , Satisfação Pessoal , Adolescente , Adulto , Fatores Etários , Idoso , Índice de Massa Corporal , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Obesidade/epidemiologia , Caracteres Sexuais , Fatores Sexuais , Espanha/epidemiologia , Adulto JovemRESUMO
We examined tau haplotype frequencies in two different ethnical groups from the Basque Country (BC): Roma people and residents of European ancestry (general population). In addition, we analyzed the spatial distribution of tau haplotypes in Eurasian populations to explore the genetic affinities of the Romani groups living in Europe in a broader scope. The 17q21.31 genomic region was characterized through the genotyping of two diagnostic single nucleotide polymorphisms, SNPs (rs10514879 and rs199451), which allow the identification of H1 and H2 haplotypes. A significant heterozygous deficit was detected in the Romani for rs10514879. The H2 haplotype frequency proved to be more than twice in the BC general population (0.283) than in the Roma people (0.127). In contrast, H2 frequency proved to be very similar between Basque and Hungarian Romani, and similar to the H2 frequencies found in northwestern India and Pakistan as well. Several statistical analyses unveiled genetic structuring for the MAPT diversity, mirrored in a significant association between geography and genetic distances, with an upward trend of H2 haplotype frequencies from Asia to Europe. Yet, Roma samples did not fit into this general spatial patterning because of their discrepancy between geographical position and H2 frequency. Despite the long spatial coexistence in the Basque region between the residents of European ancestry and the Roma, the latter have preserved their Asian genetic ancestry. Bearing in mind the lack of geographical barriers between both ethnical groups, these findings support the notion that sociocultural mores might promote assortative matings in human populations.
Assuntos
Genética Populacional , Roma (Grupo Étnico)/genética , Proteínas tau/genética , Povo Asiático/genética , Frequência do Gene , Técnicas de Genotipagem , Haplótipos , Humanos , Polimorfismo de Nucleotídeo Único , Espanha , População Branca/genéticaRESUMO
Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences made from twin studies in general. We analyzed whether there were differences in individual, maternal and paternal education between MZ and DZ twins in a large pooled dataset. Information was gathered on individual education for 218,362 adult twins from 27 twin cohorts (53% females; 39% MZ twins), and on maternal and paternal education for 147,315 and 143,056 twins respectively, from 28 twin cohorts (52% females; 38% MZ twins). Together, we had information on individual or parental education from 42 twin cohorts representing 19 countries. The original education classifications were transformed to education years and analyzed using linear regression models. Overall, MZ males had 0.26 (95% CI [0.21, 0.31]) years and MZ females 0.17 (95% CI [0.12, 0.21]) years longer education than DZ twins. The zygosity difference became smaller in more recent birth cohorts for both males and females. Parental education was somewhat longer for fathers of DZ twins in cohorts born in 1990-1999 (0.16 years, 95% CI [0.08, 0.25]) and 2000 or later (0.11 years, 95% CI [0.00, 0.22]), compared with fathers of MZ twins. The results show that the years of both individual and parental education are largely similar in MZ and DZ twins. We suggest that the socio-economic differences between MZ and DZ twins are so small that inferences based upon genetic modeling of twin data are not affected.
Assuntos
Sucesso Acadêmico , Modelos Genéticos , Gêmeos Dizigóticos , Gêmeos Monozigóticos , Estudos de Coortes , Feminino , Humanos , Masculino , Fatores SocioeconômicosRESUMO
BACKGROUND: Earlier menarche has been related to shorter height and greater obesity-related anthropometric dimensions and blood pressure in women. Boys and girls with earlier maternal menarcheal age (MMA) have shown greater height and body mass index (BMI) in childhood. AIM: To analyse associations of menarcheal age with their own and their children's anthropometric dimensions and blood pressure. SUBJECTS AND METHODS: The sample consisted of 493 women and their children (aged 2-19 years) from Greater Bilbao (Basque Country, Spain). For both generations there is information on 19 anthropometric dimensions, blood pressure and socio-demographic characteristics. Linear regressions adjusted for different covariates were used to analyse the associations. RESULTS: Menarcheal age in women showed the greatest positive associations with iliospinal height and ectomorphy and negative associations with BMI, sum of six skin-folds, endomorphy and mesomorphy. Boys with earlier MMA had greater body heights and breadths, particularly iliospinal height and biacromial breadth (0.10 z-score/year; p < 0.05). In girls, earlier MMA predicted greater sitting height, biepicondylar humerus breadth, weight and sum of four circumferences (0.07-0.09 z-score/year; p < 0.05). However, there was some evidence that MMA was positively associated with body heights, ectomorphy and blood pressure in girls aged ≥12. CONCLUSION: Children with earlier MMA tend to have greater anthropometric dimensions. Adolescent growth spurt might affect these relationships, at least in girls.
Assuntos
Antropometria , Pressão Sanguínea/fisiologia , Menarca/fisiologia , Adulto , Fatores Etários , Criança , Feminino , Humanos , Masculino , Análise de Regressão , Autorrelato , EspanhaRESUMO
PURPOSE: To evaluate whether adolescents with a positive score in a screening tool for possible eating disorders (ED) have a different diet intake in comparison with those with a negative score. METHODS: Cross-sectional study performed in 235 adolescents (37.9 % boys) from Zaragoza (Spain). Age, gender, BMI, maternal education, nutrient intake (7-day record) and screening tool for detecting ED [sick control on fat food test (SCOFF)] were assessed. ANCOVA test was used to determine nutrient intake differences (namely energy, macronutrients and micronutrients) according to the SCOFF total score (SCOFF ≥2 indicates a possible case of ED). ANCOVA test was adjusted by age, maternal education and BMI. This research was based on data from the cross-sectional multicenter Alimentación y Valoración del Estado Nutricional en Adolescentes españoles (Feeding and Assessment of Nutritional status of Spanish Adolescents) study. RESULTS: The proportion of adolescents with possible symptoms of ED was 21.7 %. Girls SCOFF high-scorers (SCOFF+) mean daily energy intake was significantly lower than in those SCOFF low-scorers (SCOFF-) (P < 0.001); however, in boys there was no difference. Both in girls and boys, there were no statistically significant differences according to SCOFF questionnaire for macronutrient intake, adjusted by daily energy intake. Concerning micronutrients, in girls with SCOFF+ sodium, potassium, phosphorus, iron, zinc, vitamin B2 and niacin intakes were significantly lower than in those with SCOFF-; however, in boys, there were no differences. CONCLUSIONS: Adolescent girls with current possible symptoms of ED presented lower total energy intake and several micronutrients intake compared with their peers without ED.
Assuntos
Ingestão de Energia , Transtornos da Alimentação e da Ingestão de Alimentos/diagnóstico , Estado Nutricional , Adolescente , Estudos Transversais , Feminino , Humanos , Masculino , Espanha , Inquéritos e QuestionáriosRESUMO
OBJECTIVE: Specific bioelectrical impedance vector analysis (spBIVA) is a recently proposed technique for the analysis of body composition. The aim of this study was to apply spBIVA to a sample of Italian and Spanish young adults and to define the new bioelectrical references for this Western Mediterranean population. METHODS: A sample of 440 individuals (220 from Italy, 220 from Spain; 213 men, 227 women) aged 18-30 years was considered. Anthropometric (height, weight, relaxed upper arm, waist, and calf girths) and bioelectrical (resistance, reactance; 50 kHz, 800 µA) measurements were taken. In order to verify the need for new references, specific bioelectrical values were compared to the reference values for U.S. adults and Italian elderly by tolerance ellipses and Student's t test. RESULTS: The mean specific bioelectrical values (resistivity, Rsp, and reactivity, Xcsp, Ohm·cm) were: Rsp (332.7 ± 41.7 Ω·cm), Xcsp (44.4 ± 6.8 Ω·cm), Zsp (335.6 ± 41.9 Ω·cm) and phase (7.6 ± 0.8°) in men; Rsp (388.6 ± 60 Ω·cm), Xcsp (43.7 ± 7.5 Ω·cm), Zsp (391.0 ± 60.3 Ω·cm) and phase (6.4 ± 0.7°) in women. Italo-Spanish bioelectrical vectors were mainly distributed (>90%) in the lower part of the tolerance ellipses for U.S. young adults, due to a shorter impedance (P < 0.001), indicative of a lower percent fat mass. Compared to Italian elders, they were mainly located in the left side (>90%), due to a higher phase (P < 0.001), indicative of higher body cell mass. CONCLUSIONS: These population and age-related differences indicate the need for new specific tolerance ellipses that can be used as references for assessing body composition in young adults from Western Mediterranean populations.
Assuntos
Antropometria/métodos , Composição Corporal , Adolescente , Adulto , Fatores Etários , Impedância Elétrica , Feminino , Humanos , Itália , Masculino , Valores de Referência , Reprodutibilidade dos Testes , Espanha , População Branca , Adulto JovemRESUMO
OBJECTIVES: The objective of this study is to investigate the association between previously GWAS identified genetic variants predisposing to obesity in Europeans and obesity-related phenotypes in Roma population. METHODS: A total of 24 representative single nucleotide polymorphisms (SNPs) were genotyped in 372 individuals belonging to 50 extended families of Roma population. SNPs were tested for association with seven quantitative obesity-related phenotypes in the PLINK program. RESULTS: Risk variants in NEGR1, FAIM2, FTO, and SH2B1 genes were associated with increased adiposity accumulation in Roma population with effect sizes between 0.21 and 0.34 Z-scores for each copy of the BMI increasing allele. Additionally, variants in BDNF and MC4R were significantly associated with adiposity distribution but not with overall fatness. No significant association was detected between obesity-related phenotypes and variants in the first intron of the FTO gene (e.g., rs9939609). CONCLUSIONS: The results of this study suggest that SNPs in or near six genes (BDNF, FAIM2, FTO, MC4R, NEGR1, and SH2B1) are significantly associated with body fat accumulation and distribution in Roma people. However, the association observed among variants in the first intron of FTO and obesity in European derived populations is not evident in the analyzed Roma sample.
Assuntos
Adiposidade , Obesidade/genética , Polimorfismo de Nucleotídeo Único , Adiposidade/etnologia , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Obesidade/epidemiologia , Obesidade/etnologia , Roma (Grupo Étnico) , Espanha/epidemiologia , Adulto JovemRESUMO
BACKGROUND: Roma people are particularly vulnerable to developing overweight and obesity. Self-perception of body image may influence the prevalence of obesity in this ethnic minority. AIM: The objectives of this study are to estimate the prevalence of obesity, to analyse body size perceptions and preferences and to assess the relationship between body size perceptions and obesity in the Roma population. SUBJECTS AND METHODS: The analyses were carried out on 372 men, women and children from the Roma population residing in the Greater Bilbao region (Basque Country, Spain). In adults, a standard figural scale was used to analyse body size perceptions and preferences in this ethnic minority. RESULTS: Overall 51.7% of adult and 24.4% of minor Roma individuals were obese. Both Roma men and women had inaccurate self-perceptions of their body size. Significant differences on body size perceptions were detected based on age, sex, nutritional status and socioeconomic characteristics. CONCLUSION: This Roma population presents one of the highest rates of obesity worldwide. Although a certain awareness of the correct weight status was appreciated, the inability of Roma individuals to see themselves as overweight or obese may be a significant factor on the high prevalence of obesity in this population.
Assuntos
Imagem Corporal , Obesidade/epidemiologia , Sobrepeso/epidemiologia , Adolescente , Adulto , Idoso , Tamanho Corporal , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Obesidade Infantil/epidemiologia , Prevalência , Roma (Grupo Étnico)/etnologia , Percepção de Tamanho , Espanha/epidemiologia , Adulto JovemRESUMO
Modern humans evolved in Africa some 200,000 years ago, and since then, human populations have expanded and diversified to occupy a broad range of habitats and use different subsistence modes. This has resulted in different adaptations, such as differential responses to diseases and different abilities to digest or tolerate certain foods. The shift from a subsistence strategy based on hunting and gathering during the Palaeolithic to a lifestyle based on the consumption of domesticated animals and plants in the Neolithic can be considered one of the most important dietary transitions of Homo sapiens. In this text, we review four examples of gene-culture coevolution: (i) the persistence of the enzyme lactase after weaning, which allows the digestion of milk in adulthood, related to the emergence of dairy farming during the Neolithic; (ii) the population differences in alcohol susceptibility, in particular the ethanol intolerance of Asian populations due to the increased accumulation of the toxic acetaldehyde, related to the spread of rice domestication; (iii) the maintenance of gluten intolerance (celiac disease) with the subsequent reduced fitness of its sufferers, related to the emergence of agriculture and (iv) the considerable variation in the biosynthetic pathway of long-chain polyunsaturated fatty acids in native populations with extreme diets.
Assuntos
Dieta , Humanos , Evolução Biológica , Animais , Evolução Cultural , Adaptação Fisiológica , Lactase/genética , Lactase/metabolismoRESUMO
Lifestyle is related to the risk of obesity, but the relationship between different lifestyle features and obesity phenotypes remains unclear. This study analysed the association between different lifestyle features (eating habits, activity, sleep patterns, and tobacco and alcohol consumption), and four obesity phenotypes (overall and abdominal obesity, distribution and percentage of fat). The sample included 521 adults aged between 18 and 70 years. A multiple logistic regression model was used, controlling for sex, age and socioeconomic status. The duration of the main meal was inversely associated with overall and abdominal obesity (p < 0.01) whereas the number of meals was positively associated (p < 0.05). Regular sport practice and duration were negatively associated with all obesity phenotypes (p < 0.01), while watching television showed positive associations. Walking was inversely related to overall and abdominal obesity (p < 0.01), whereas sleep quality was positively associated with both phenotypes. Former smokers showed a positive relationship with both abdominal obesity (p = 0.021) and fat mass distribution (p = 0.002), and the number of cigarettes were positively related with all obesity phenotypes (p < 0.01), except with fat distribution. Alcohol consumption was inversely related with an excessive adiposity (p = 0.030), while occasional drinking was negatively related with overall obesity and an excess of fat. In conclusion, few meals per day, a bad or regular quality of sleep, many hours spent watching television and a heavy cigarette consumption significantly increased the risk of various obesity phenotypes, while time spent at the main meal, walking and sport practice, and a moderate alcohol consumption were associated with a decreased risk.
RESUMO
Obesity has become a public-health and policy problem in many parts of the world. Epidemiological and population studies in this field are usually based on different anthropometric measures; however, common genetic and environmental factors between these phenotypes have been scarcely studied. The objective of this article is to assess the strength of these factors on the covariation among a large set of obesity-related traits. The subject group consisted of 533 nuclear families living in the Greater Bilbao (Spain), and included 1,702 individuals aged 2-61 years. Detailed anthropometric measurements (stature, breadths, circumferences and skinfolds) were carried out in each subject. Bivariate quantitative genetic analyses were performed using a variance-components procedure implemented in the software SOLAR. The results revealed that the majority of these traits is affected by common genetic and environmental factors. All correlations were significantly different from 1 and varied from non-significant to very high (>0.90, P < 0.0001), with clearly lower pleiotropic effects among pairs including fat-distribution traits. Despite the strong common genetic effects detected among phenotypes determining the amount of body fat and mass, there is a residual genetic influence on the local fatness measures that cannot be explained exclusively by the genetic influence on overall fatness. Moreover, the observed relationships confirm a partially different genetic control of truncal and peripheral fat. In conclusion, our findings highlight the relevance of considering different types of traits in the prevention and treatment of obesity, as well as in the search for genes involved in its development.
Assuntos
Interação Gene-Ambiente , Obesidade/genética , Adolescente , Adulto , Antropometria , Distribuição de Qui-Quadrado , Criança , Pré-Escolar , Estudos Transversais , Ligação Genética , Humanos , Lactente , Pessoa de Meia-Idade , Núcleo Familiar , Fenótipo , Análise de Regressão , Dobras Cutâneas , EspanhaRESUMO
BACKGROUND: The Roma people are particularly vulnerable to developing obesity and related diseases, due to their social and ethnic backgrounds. However, little is known about the genetic and/or environmental factors affecting the variability of obesity-related traits among the Roma population. AIM: The aim of the present study was to estimate heritabilities and common genetic and environmental influences of obesity-related phenotypes in a sample of Roma people living in the Greater Bilbao region (Basque Country; Spain). SUBJECTS AND METHODS: Three hundred and seventy-two individuals from 50 large, extended and highly consanguineous pedigrees were phenotyped for anthropometric traits related to obesity. Heritability estimates were assessed for all quantitative traits and bivariate analyses were conducted to assess the phenotypic, genetic and environmental correlations among these traits. RESULTS: Significant heritable components (p<0.01) ranging from 0.25-0.68 exist for the studied phenotypes. Heritability for WHR (h(2) =0.60) considerably surpasses the usual heritability estimates on family-based studies ( <0.30). Measures of overall fatness (BMI, CF and SF) show stronger correlations with each other than body fat distribution traits (WHR, CI and TER). CONCLUSIONS: The study concluded that the Greater Bilbao Roma population is genetically predisposed to abdominal fat distribution. Variation in body mass is highly associated with variation in adiposity. However, overall fatness and adiposity distribution does not seem to share major common genetic factors, although common environmental factors operate between them.
Assuntos
Etnicidade/genética , Predisposição Genética para Doença , Padrões de Herança/genética , Obesidade/genética , Adulto , Criança , Análise Fatorial , Feminino , Interação Gene-Ambiente , Humanos , Masculino , Fenótipo , Espanha/etnologiaRESUMO
OBJECTIVE: The aim of this study was to investigate food purchasing behaviors, choice determinants, and opinions about on-campus food availability by a university community and to analyze differences in these aspects between students, education and/or research staff (ERS), and administrative and services staff (ASS), and between males and females. METHODS: This was a cross-sectional study that involved a representative sample of students (n = 1089), ERS (n = 396), and ASS (n = 300) who completed an anonymous online survey. A previously adapted version of the questionnaire was administered. The results were weighted to ensure representativeness of this community population using weighted coefficients. RESULTS: The results showed that most of the participants purchased food on campus (91.6%), especially for lunch (67.4% of foods and 37.4% of drinks) and snack (65.4% of foods and 45.4% of drinks). Hot drinks (i.e., coffee, tea, hot chocolate etc.; 60.5%), bottled water (49.2%), and hot foods (i.e., small servings [38.2%] and sandwiches/hamburgers [31.7%]) were the most purchased items. Taste (98.6%) was the most important determinant in choice, followed by price for students, nutritional value for ASS, and health value for ERS. The "top 5" opinions suggested for the campus food environment and potential changes were "greater capacity to access free filtered drinking water", "greater capacity to recycle food packaging," "more healthy options in vending machines", "discounts for healthy choices," and "allergen labeling." CONCLUSION: Interventions that improve sustainability and the affordability of products with high nutritional quality, price-manipulation directives, and allergen information on labeling would be well received among this community.
Assuntos
Bebidas , Distribuidores Automáticos de Alimentos , Feminino , Humanos , Masculino , Alérgenos , Comportamento de Escolha , Estudos Transversais , Alimentos , Lanches , UniversidadesRESUMO
We tested the causality between education and smoking using the natural experiment of discordant twin pairs allowing to optimally control for background genetic and childhood social factors. Data from 18 cohorts including 10,527 monozygotic (MZ) and same-sex dizygotic (DZ) twin pairs discordant for education and smoking were analyzed by linear fixed effects regression models. Within twin pairs, education levels were lower among the currently smoking than among the never smoking co-twins and this education difference was larger within DZ than MZ pairs. Similarly, education levels were higher among former smoking than among currently smoking co-twins, and this difference was larger within DZ pairs. Our results support the hypothesis of a causal effect of education on both current smoking status and smoking cessation. However, the even greater intra-pair differences within DZ pairs, who share only 50% of their segregating genes, provide evidence that shared genetic factors also contribute to these associations.
Assuntos
Abandono do Hábito de Fumar , Gêmeos Monozigóticos , Criança , Escolaridade , Humanos , Fumar/genética , Gêmeos Dizigóticos/genética , Gêmeos Monozigóticos/genéticaRESUMO
OBJECTIVES: Human growth is a complex process that remains insufficiently understood. We aimed to analyze genetic and environmental influences on growth from late childhood to early adulthood. METHODS: Two cohorts of monozygotic and dizygotic (same sex and opposite sex) Finnish twin pairs were studied longitudinally using self-reported height at 11-12, 14, and 17 years and adult age (FinnTwin12) and at 16, 17, and 18 years and adult age (FinnTwin16). Univariate and multivariate variance component models for twin data were used. RESULTS: From childhood to adulthood, genetic differences explained 72-81% of the variation of height in boys and 65-86% in girls. Environmental factors common to co-twins explained 5-23% of the variation of height, with the residual variation explained by environmental factors unique to each twin individual. Common environmental factors affecting height were highly correlated between the analyzed ages (0.72-0.99 and 0.91-1.00 for boys and girls, respectively). Genetic (0.58-0.99 and 0.70-0.99, respectively) and unique environmental factors (0.32-0.78 and 0.54-0.82, respectively) affecting height at different ages were more weakly, but still substantially, correlated. CONCLUSIONS: The genetic contribution to height is strong during adolescence. The high genetic correlations detected across the ages encourage further efforts to identify genes affecting growth. Common and unique environmental factors affecting height during adolescence are also important, and further studies are necessary to identify their nature and test whether they interact with genetic factors.