Pesquisa | Secretaria de Estado da Saúde

1.

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.

Schreiber, Stuart L; Kotz, Joanne D; Li, Min; Aubé, Jeffrey; Austin, Christopher P; Reed, John C; Rosen, Hugh; White, E Lucile; Sklar, Larry A; Lindsley, Craig W; Alexander, Benjamin R; Bittker, Joshua A; Clemons, Paul A; de Souza, Andrea; Foley, Michael A; Palmer, Michelle; Shamji, Alykhan F; Wawer, Mathias J; McManus, Owen; Wu, Meng; Zou, Beiyan; Yu, Haibo; Golden, Jennifer E; Schoenen, Frank J; Simeonov, Anton; Jadhav, Ajit; Jackson, Michael R; Pinkerton, Anthony B; Chung, Thomas D Y; Griffin, Patrick R; Cravatt, Benjamin F; Hodder, Peter S; Roush, William R; Roberts, Edward; Chung, Dong-Hoon; Jonsson, Colleen B; Noah, James W; Severson, William E; Ananthan, Subramaniam; Edwards, Bruce; Oprea, Tudor I; Conn, P Jeffrey; Hopkins, Corey R; Wood, Michael R; Stauffer, Shaun R; Emmitte, Kyle A.

Cell ; 161(6): 1252-65, 2015 Jun 04.

Artigo Inglês | MEDLINE | ID: mdl-26046436

2.

The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.

Khare, Sonal; Ratsimandresy, Rojo A; de Almeida, Lúcia; Cuda, Carla M; Rellick, Stephanie L; Misharin, Alexander V; Wallin, Melissa C; Gangopadhyay, Anu; Forte, Eleonora; Gottwein, Eva; Perlman, Harris; Reed, John C; Greaves, David R; Dorfleutner, Andrea; Stehlik, Christian.

Nat Immunol ; 15(4): 343-53, 2014 Apr.

Artigo Inglês | MEDLINE | ID: mdl-24531343

3.

K63 ubiquitination in immune signaling.

Madiraju, Charitha; Novack, Jeffrey P; Reed, John C; Matsuzawa, Shu-Ichi.

Trends Immunol ; 43(2): 148-162, 2022 02.

Artigo Inglês | MEDLINE | ID: mdl-35033428

4.

Correction: Regulation of ATG4B Stability by RNF5 Limits Basal Levels of Autophagy and Influences Susceptibility to Bacterial Infection.

Kuang, Ersheng; Okumura, Cheryl Y M; Sheffy-Levin, Sharon; Varsano, Tal; Shu, Vincent Chih-Wen; Qi, Jianfei; Niesman, Ingrid R; Yang, Huei-Jiun; López-Otín, Carlos; Yang, Wei Yuan; Reed, John C; Broday, Limor; Nizet, Victor; Ronai, Ze'ev A.

PLoS Genet ; 16(5): e1008795, 2020 05.

Artigo Inglês | MEDLINE | ID: mdl-32392217

5.

Ironing out cell death mechanisms.

Reed, John C; Pellecchia, Maurizio.

Cell ; 149(5): 963-5, 2012 May 25.

Artigo Inglês | MEDLINE | ID: mdl-22632964

6.

Endoplasmic reticulum protein BI-1 regulates Ca²âº-mediated bioenergetics to promote autophagy.

Sano, Renata; Hou, Ying-Chen Claire; Hedvat, Michael; Correa, Ricardo G; Shu, Chih-Wen; Krajewska, Maryla; Diaz, Paul W; Tamble, Craig M; Quarato, Giovanni; Gottlieb, Roberta A; Yamaguchi, Masaya; Nizet, Victor; Dahl, Russell; Thomas, David D; Tait, Stephen W; Green, Douglas R; Fisher, Paul B; Matsuzawa, Shu-Ichi; Reed, John C.

Genes Dev ; 26(10): 1041-54, 2012 May 15.

Artigo Inglês | MEDLINE | ID: mdl-22588718

7.

Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding.

Zhong, Franklin L; Robinson, Kim; Teo, Daniel Eng Thiam; Tan, Kiat-Yi; Lim, Chrissie; Harapas, Cassandra R; Yu, Chien-Hsiung; Xie, William H; Sobota, Radoslaw M; Au, Veonice Bijin; Hopkins, Richard; D'Osualdo, Andrea; Reed, John C; Connolly, John E; Masters, Seth L; Reversade, Bruno.

J Biol Chem ; 293(49): 18864-18878, 2018 12 07.

Artigo Inglês | MEDLINE | ID: mdl-30291141

8.

ARTS and Siah collaborate in a pathway for XIAP degradation.

Garrison, Jason B; Correa, Ricardo G; Gerlic, Motti; Yip, Kenneth W; Krieg, Andreas; Tamble, Craig M; Shi, Ranxin; Welsh, Kate; Duggineni, Srinivas; Huang, Ziwei; Ren, Keqin; Du, Chunying; Reed, John C.

Mol Cell ; 41(1): 107-16, 2011 Jan 07.

Artigo Inglês | MEDLINE | ID: mdl-21185211

9.

Therapeutics targeting Bcl-2 in hematological malignancies.

Ruefli-Brasse, Astrid; Reed, John C.

Biochem J ; 474(21): 3643-3657, 2017 10 23.

Artigo Inglês | MEDLINE | ID: mdl-29061914

10.

Orphan Nuclear Receptor NR4A1 Binds a Novel Protein Interaction Site on Anti-apoptotic B Cell Lymphoma Gene 2 Family Proteins.

Godoi, Paulo H C; Wilkie-Grantham, Rachel P; Hishiki, Asami; Sano, Renata; Matsuzawa, Yasuko; Yanagi, Hiroko; Munte, Claudia E; Chen, Ya; Yao, Yong; Marassi, Francesca M; Kalbitzer, Hans R; Matsuzawa, Shu-Ichi; Reed, John C.

J Biol Chem ; 291(27): 14072-14084, 2016 Jul 01.

Artigo Inglês | MEDLINE | ID: mdl-27129202

11.

Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia.

Pan, Rongqing; Ruvolo, Vivian R; Wei, Jun; Konopleva, Marina; Reed, John C; Pellecchia, Maurizio; Andreeff, Michael; Ruvolo, Peter P.

Blood ; 126(3): 363-72, 2015 Jul 16.

Artigo Inglês | MEDLINE | ID: mdl-26045609

12.

Non-apoptotic role of BID in inflammation and innate immunity.

Yeretssian, Garabet; Correa, Ricardo G; Doiron, Karine; Fitzgerald, Patrick; Dillon, Christopher P; Green, Douglas R; Reed, John C; Saleh, Maya.

Nature ; 474(7349): 96-9, 2011 Jun 02.

Artigo Inglês | MEDLINE | ID: mdl-21552281

13.

BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha.

Lisbona, Fernanda; Rojas-Rivera, Diego; Thielen, Peter; Zamorano, Sebastian; Todd, Derrick; Martinon, Fabio; Glavic, Alvaro; Kress, Christina; Lin, Jonathan H; Walter, Peter; Reed, John C; Glimcher, Laurie H; Hetz, Claudio.

Mol Cell ; 33(6): 679-91, 2009 Mar 27.

Artigo Inglês | MEDLINE | ID: mdl-19328063

14.

ATG4B (Autophagin-1) phosphorylation modulates autophagy.

Yang, Zhifen; Wilkie-Grantham, Rachel P; Yanagi, Teruki; Shu, Chih-Wen; Matsuzawa, Shu-Ichi; Reed, John C.

J Biol Chem ; 290(44): 26549-61, 2015 Oct 30.

Artigo Inglês | MEDLINE | ID: mdl-26378241

15.

Corrigendum to "Nod 1, a CARD protein, enhances pro-interleukin-1 beta processing through the interaction with pro-caspase-1" [Biochem. Biophys. Res. Commun. 299(4) (2002) 652-8].

Yoo, Nam Jin; Park, Won Sang; Kim, Su Young; Reed, John C; Son, Seong Gon; Lee, Jung Young; Lee, Sug Hyung.

Biochem Biophys Res Commun ; 543: 97, 2021 Mar 05.

Artigo Inglês | MEDLINE | ID: mdl-33518282

16.

Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation.

Gerlic, Motti; Faustin, Benjamin; Postigo, Antonio; Yu, Eric Chi-Wang; Proell, Martina; Gombosuren, Naran; Krajewska, Maryla; Flynn, Rachel; Croft, Michael; Way, Michael; Satterthwait, Arnold; Liddington, Robert C; Salek-Ardakani, Shahram; Matsuzawa, Shu-ichi; Reed, John C.

Proc Natl Acad Sci U S A ; 110(19): 7808-13, 2013 May 07.

Artigo Inglês | MEDLINE | ID: mdl-23603272

17.

XIAP variants in male Crohn's disease.

Zeissig, Yvonne; Petersen, Britt-Sabina; Milutinovic, Snezana; Bosse, Esther; Mayr, Gabriele; Peuker, Kenneth; Hartwig, Jelka; Keller, Andreas; Kohl, Martina; Laass, Martin W; Billmann-Born, Susanne; Brandau, Heide; Feller, Alfred C; Röcken, Christoph; Schrappe, Martin; Rosenstiel, Philip; Reed, John C; Schreiber, Stefan; Franke, Andre; Zeissig, Sebastian.

Gut ; 64(1): 66-76, 2015 Jan.

Artigo Inglês | MEDLINE | ID: mdl-24572142

18.

HIV-1 protease cleaves the serine-threonine kinases RIPK1 and RIPK2.

Wagner, Roland N; Reed, John C; Chanda, Sumit K.

Retrovirology ; 12: 74, 2015 Aug 22.

Artigo Inglês | MEDLINE | ID: mdl-26297639

19.

Peter C. Nowell (1928-2016).

Reed, John C; Druker, Brian J.

Proc Natl Acad Sci U S A ; 114(18): 4569-4570, 2017 05 02.

Artigo Inglês | MEDLINE | ID: mdl-28416695

20.

Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection.