Detalhe da pesquisa
1.
Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer.
Nature
; 2024 Apr 08.
Artigo
Inglês
| MEDLINE | ID: mdl-38588697
2.
The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity.
Nature
; 622(7984): 850-862, 2023 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-37794185
3.
Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death.
Nat Chem Biol
; 19(3): 301-310, 2023 03.
Artigo
Inglês
| MEDLINE | ID: mdl-36302897
4.
Targeting ROS production through inhibition of NADPH oxidases.
Nat Chem Biol
; 19(12): 1540-1550, 2023 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-37884805
5.
Systematic identification of biomarker-driven drug combinations to overcome resistance.
Nat Chem Biol
; 18(6): 615-624, 2022 06.
Artigo
Inglês
| MEDLINE | ID: mdl-35332332
6.
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.
Nature
; 547(7664): 453-457, 2017 07 27.
Artigo
Inglês
| MEDLINE | ID: mdl-28678785
7.
Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.
Nat Chem Biol
; 12(2): 102-8, 2016 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-26656089
8.
Correlating chemical sensitivity and basal gene expression reveals mechanism of action.
Nat Chem Biol
; 12(2): 109-16, 2016 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-26656090
9.
Inheritance of rare functional GCKR variants and their contribution to triglyceride levels in families.
Hum Mol Genet
; 23(20): 5570-8, 2014 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24879641
10.
Glucokinase regulatory protein: complexity at the crossroads of triglyceride and glucose metabolism.
Curr Opin Lipidol
; 26(2): 88-95, 2015 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-25692341
11.
Discovery of a Small-Molecule Probe for V-ATPase Function.
J Am Chem Soc
; 137(16): 5563-8, 2015 Apr 29.
Artigo
Inglês
| MEDLINE | ID: mdl-25860544
12.
Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis.
Mol Cancer Ther
; 23(4): 478-491, 2024 Apr 02.
Artigo
Inglês
| MEDLINE | ID: mdl-37988559
13.
Discovery and Characterization of Selective, First-in-Class Inhibitors of Citron Kinase.
J Med Chem
; 67(4): 2631-2666, 2024 Feb 22.
Artigo
Inglês
| MEDLINE | ID: mdl-38330278
14.
A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma.
Cancer Res
; 84(6): 872-886, 2024 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38486486
15.
Genetic dependencies associated with transcription factor activities in human cancer cell lines.
Cell Rep
; 43(5): 114175, 2024 Apr 30.
Artigo
Inglês
| MEDLINE | ID: mdl-38691456
16.
Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition.
Nat Commun
; 15(1): 3483, 2024 Apr 25.
Artigo
Inglês
| MEDLINE | ID: mdl-38664416
17.
Highly specific intracellular ubiquitination of a small molecule.
bioRxiv
; 2024 Jan 28.
Artigo
Inglês
| MEDLINE | ID: mdl-38328167
18.
Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers.
Nat Cancer
; 5(1): 66-84, 2024 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-38151625
19.
Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions.
Nat Metab
; 5(5): 765-776, 2023 05.
Artigo
Inglês
| MEDLINE | ID: mdl-37198474
20.
Systematic profiling of conditional pathway activation identifies context-dependent synthetic lethalities.
Nat Genet
; 55(10): 1709-1720, 2023 10.
Artigo
Inglês
| MEDLINE | ID: mdl-37749246