RESUMO
BACKGROUND: The main objective of this study was to estimate the prevalence of human papillomavirus-DNA (HPV-DNA) in the saliva of sexually active women with HPV-related cervical intraepithelial neoplasias (CIN) and compare the findings with a healthy control group. The secondary objectives were: 1) to determine the concordance between genital and oral HPV types in sexually active women with HPV-related CIN; 2) to analyze whether sexual habits influence the presence of HPV-related CIN; 3) to determine whether sexual habits influence the presence of oral HPV. MATERIAL AND METHODS: Saliva samples were collected from 100 sexually active women, 50 with HPV-related CIN and 50 healthy subjects presenting normal cytology. PCR assay was used to detect HPV-DNA. RESULTS: The prevalence of oral HPV infection in saliva samples was 14% in women with HPV-related CIN, while in the healthy group it was 12%, without statistically significant difference (p=0.766). As for the concordance between genital and oral HPV types in women with HPV-related CIN, concordance was only observed for HPV-16, whereby among 22 women with genital HPV-16, only one (4.54%) also presented oral HPV-16. Regarding the possible influence of sexual habits on the presence of cervical pathology and presence of oral HPV, it was found that marital status, age at first intercourse, number of lifetime sexual partners, and condom use are related with the presence of cervical pathology (p<0.001; p=0.017; p=0.002; and p<0.001, respectively); condom use was also found to be related to the presence of oral HPV (p<0.001). CONCLUSIONS: The prevalence of HPV-DNA in the saliva of sexually active women with HPV-related CIN is similar to healthy women. The concordance between genital and oral HPV types is low. Both the presence of cervical pathology and the presence of oral HPV are related to sexual habits. Wider sample size is required to confirm this results.
Assuntos
Papillomaviridae , Infecções por Papillomavirus , Displasia do Colo do Útero , Neoplasias do Colo do Útero , Feminino , Humanos , Prevalência , Fatores de Risco , SalivaRESUMO
Antecedentes: La metaplasia ósea del endometrio es una enfermedad rara, que suele manifestarse como infertilidad secundaria. Objetivo: Reportar un caso clínico y hacer una revisión de la literatura, sugiriendo una tríada diagnóstica para esta enfermedad. Caso clínico: Paciente de 40 años de edad, con imagen hiperrefringente en la ecografía, sangrado uterino anormal y calcificaciones en la histeroscopia. Conclusión: La tríada de infertilidad, antecedente de aborto previo y áreas hiperrefringentes endometriales en la ecografía, debe hacernos sospechar de metaplasia ósea, debiendo realizar histeroscopia diagnóstica y resección del tejido
Background: Osseous metaplasia of the endometrium is a rare pathology that usually presents with secondary infertility. Objective: To present a case report and literature review and propose a diagnostic triad for this condition. Clinic case: A 40-year-old patient who presents with hyperechogenic areas in the ultrasound scan, abnormal uterine bleeding and calcifications in the hysteroscopy. Conclusion: The triad of infertility, previous miscarriage and hyperechogenic areas of the endometrium revealed by ultrasound scan is suggestive of osseous metaplasia, for which diagnostic hysteroscopy and tissue resection is indicated