Detalhe da pesquisa
1.
Pharmacological Characterization of Aprocitentan, a Dual Endothelin Receptor Antagonist, Alone and in Combination with Blockers of the Renin Angiotensin System, in Two Models of Experimental Hypertension.
J Pharmacol Exp Ther
; 368(3): 462-473, 2019 03.
Artigo
Inglês
| MEDLINE | ID: mdl-30622171
2.
S1P1 Modulator-Induced G αi Signaling and ß-Arrestin Recruitment Are Both Necessary to Induce Rapid and Efficient Reduction of Blood Lymphocyte Count In Vivo.
Mol Pharmacol
; 93(2): 109-118, 2018 02.
Artigo
Inglês
| MEDLINE | ID: mdl-29203519
3.
Milestones to the Discovery of T-type Calcium Channel Blockers for the Treatment of Generalized Epilepsies.
Chimia (Aarau)
; 71(10): 722-729, 2017 Oct 25.
Artigo
Inglês
| MEDLINE | ID: mdl-29070417
4.
A novel genomic signature with translational significance for human idiopathic pulmonary fibrosis.
Am J Respir Cell Mol Biol
; 52(2): 217-31, 2015 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-25029475
5.
Vascular Effects of Endothelin Receptor Antagonists Depends on Their Selectivity for ETA Versus ETB Receptors and on the Functionality of Endothelial ETB Receptors.
J Cardiovasc Pharmacol
; 66(4): 332-7, 2015 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-25992919
6.
Comparison of Macitentan and Bosentan on Right Ventricular Remodeling in a Rat Model of Non-vasoreactive Pulmonary Hypertension.
J Cardiovasc Pharmacol
; 66(5): 457-67, 2015 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-26230396
7.
Discovery of novel bridged tetrahydronaphthalene derivatives as potent T/L-type calcium channel blockers.
Bioorg Med Chem Lett
; 25(18): 3941-6, 2015 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26231163
8.
Discovery of Clinical Candidate ACT-777991, a Potent CXCR3 Antagonist for Antigen-Driven and Inflammatory Pathologies.
J Med Chem
; 66(6): 4179-4196, 2023 03 23.
Artigo
Inglês
| MEDLINE | ID: mdl-36883854
9.
The P2Y12 Receptor Antagonist Selatogrel Dissolves Preformed Platelet Thrombi In Vivo.
J Clin Med
; 10(22)2021 Nov 17.
Artigo
Inglês
| MEDLINE | ID: mdl-34830631
10.
The reversible P2Y12 antagonist ACT-246475 causes significantly less blood loss than ticagrelor at equivalent antithrombotic efficacy in rat.
Pharmacol Res Perspect
; 5(5)2017 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-28805949
11.
Cenerimod, a novel selective S1P1 receptor modulator with unique signaling properties.
Pharmacol Res Perspect
; 5(6)2017 12.
Artigo
Inglês
| MEDLINE | ID: mdl-29226621
12.
Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies.
J Med Chem
; 60(23): 9769-9789, 2017 12 14.
Artigo
Inglês
| MEDLINE | ID: mdl-29116786
13.
Bosentan, sildenafil, and their combination in the monocrotaline model of pulmonary hypertension in rats.
Exp Biol Med (Maywood)
; 231(6): 967-73, 2006 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-16741032
14.
Novel S1P1 receptor agonists - Part 5: From amino-to alkoxy-pyridines.
Eur J Med Chem
; 115: 326-41, 2016 Jun 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27027817
15.
Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups.
Eur J Med Chem
; 116: 222-238, 2016 Jun 30.
Artigo
Inglês
| MEDLINE | ID: mdl-27061986
16.
Preparation, Antiepileptic Activity, and Cardiovascular Safety of Dihydropyrazoles as Brain-Penetrant T-Type Calcium Channel Blockers.
J Med Chem
; 59(18): 8398-411, 2016 Sep 22.
Artigo
Inglês
| MEDLINE | ID: mdl-27579577
17.
4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel.
J Med Chem
; 58(23): 9133-53, 2015 Dec 10.
Artigo
Inglês
| MEDLINE | ID: mdl-26550844
18.
Comparison of pharmacological activity of macitentan and bosentan in preclinical models of systemic and pulmonary hypertension.
Life Sci
; 118(2): 333-9, 2014 Nov 24.
Artigo
Inglês
| MEDLINE | ID: mdl-24582812
19.
Novel S1P(1) receptor agonists--part 3: from thiophenes to pyridines.
J Med Chem
; 57(1): 110-30, 2014 Jan 09.
Artigo
Inglês
| MEDLINE | ID: mdl-24367923
20.
Novel S1P(1) receptor agonists--part 2: from bicyclo[3.1.0]hexane-fused thiophenes to isobutyl substituted thiophenes.
J Med Chem
; 57(1): 78-97, 2014 Jan 09.
Artigo
Inglês
| MEDLINE | ID: mdl-24345087