Detalhe da pesquisa
1.
Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.
Mol Cell
; 58(5): 832-44, 2015 Jun 04.
Artigo
Inglês
| MEDLINE | ID: mdl-26028538
2.
Stenotrophomonas maltophilia OleC-Catalyzed ATP-Dependent Formation of Long-Chain Z-Olefins from 2-Alkyl-3-hydroxyalkanoic Acids.
Chembiochem
; 17(15): 1426-9, 2016 08 03.
Artigo
Inglês
| MEDLINE | ID: mdl-27238740
3.
Identification and Characterization of FabA from the Type II Fatty Acid Synthase of Streptomyces coelicolor.
J Nat Prod
; 79(1): 240-3, 2016 Jan 22.
Artigo
Inglês
| MEDLINE | ID: mdl-26731437
4.
Characterization of FabG and FabI of the Streptomyces coelicolor dissociated fatty acid synthase.
Chembiochem
; 16(4): 631-40, 2015 Mar 02.
Artigo
Inglês
| MEDLINE | ID: mdl-25662938
5.
Elucidation of final steps of the marineosins biosynthetic pathway through identification and characterization of the corresponding gene cluster.
J Am Chem Soc
; 136(12): 4565-74, 2014 Mar 26.
Artigo
Inglês
| MEDLINE | ID: mdl-24575817
6.
Stereospecific synthesis of 23-hydroxyundecylprodiginines and analogues and conversion to antimalarial premarineosins via a Rieske oxygenase catalyzed bicyclization.
J Org Chem
; 79(23): 11674-89, 2014 Dec 05.
Artigo
Inglês
| MEDLINE | ID: mdl-25380131
7.
Discovery and Optimization of Tambjamines as a Novel Class of Antileishmanial Agents.
J Med Chem
; 67(10): 8323-8345, 2024 May 23.
Artigo
Inglês
| MEDLINE | ID: mdl-38722757
8.
Functional modular dissection of DEBS1-TE changes triketide lactone ratios and provides insight into Acyl group loading, hydrolysis, and ACP transfer.
Biochemistry
; 51(46): 9333-41, 2012 Nov 20.
Artigo
Inglês
| MEDLINE | ID: mdl-23116287
9.
Structure and function of the RedJ protein, a thioesterase from the prodiginine biosynthetic pathway in Streptomyces coelicolor.
J Biol Chem
; 286(25): 22558-69, 2011 Jun 24.
Artigo
Inglês
| MEDLINE | ID: mdl-21543318
10.
Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine.
Proc Natl Acad Sci U S A
; 106(30): 12295-300, 2009 Jul 28.
Artigo
Inglês
| MEDLINE | ID: mdl-19590008
11.
Functional characterization of an NADPH dependent 2-alkyl-3-ketoalkanoic acid reductase involved in olefin biosynthesis in Stenotrophomonas maltophilia.
Biochemistry
; 50(44): 9633-40, 2011 Nov 08.
Artigo
Inglês
| MEDLINE | ID: mdl-21958090
12.
Total Synthesis and Antimalarial Activity of 2-(p-Hydroxybenzyl)-prodigiosins, Isoheptylprodigiosin, and Geometric Isomers of Tambjamine MYP1 Isolated from Marine Bacteria.
J Med Chem
; 64(12): 8739-8754, 2021 06 24.
Artigo
Inglês
| MEDLINE | ID: mdl-34111350
13.
Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.
J Med Chem
; 63(11): 6179-6202, 2020 06 11.
Artigo
Inglês
| MEDLINE | ID: mdl-32390431
14.
Biosynthesis of salinosporamides from alpha,beta-unsaturated fatty acids: implications for extending polyketide synthase diversity.
J Am Chem Soc
; 131(30): 10376-7, 2009 Aug 05.
Artigo
Inglês
| MEDLINE | ID: mdl-19601645
15.
The final step of hygromycin A biosynthesis, oxidation of C-5''-dihydrohygromycin A, is linked to a putative proton gradient-dependent efflux.
Antimicrob Agents Chemother
; 53(12): 5163-72, 2009 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-19770276
16.
Functional dissection of a multimodular polypeptide of the pikromycin polyketide synthase into monomodules by using a matched pair of heterologous docking domains.
Chembiochem
; 10(9): 1537-43, 2009 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19437523
17.
High titer production of tetracenomycins by heterologous expression of the pathway in a Streptomyces cinnamonensis industrial monensin producer strain.
Metab Eng
; 11(6): 319-27, 2009 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-19595787
18.
Application of a newly identified and characterized 18-o-acyltransferase in chemoenzymatic synthesis of selected natural and nonnatural bioactive derivatives of phoslactomycins.
Appl Environ Microbiol
; 75(11): 3469-76, 2009 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-19304832
19.
Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH.
Chem Biol
; 15(4): 402-12, 2008 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-18420147
20.
Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis.
Chem Biol
; 15(2): 137-48, 2008 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-18291318