Efficacy of Fascial Distortion Model Treatment for Acute, Nonspecific Low-Back Pain in Primary Care: A Prospective Controlled Trial.

Context • Low-back pain (LBP) is a prevalent and potentially crippling condition for which treatment is often unsatisfactory from the perspectives of physicians, patients, and payers. The application of the fascial distortion model (FDM), an integrated concept for the diagnosis and manipulative treatment of musculoskeletal disorders, is conceptually promising for LBP but has not been investigated systematically. Objective • The study intended to provide proof of concept to establish the noninferiority of the FDM treatment as opposed to the therapy recommended by the German National Disease Management Guideline (NDMG) for acute LBP. Design • The study was a prospective, nonrandomized, controlled, parallel-group trial. Setting • The study took place in a private practice for surgery and orthopedics. Participants • Seventy-seven outpatients with acute LBP with an average age of 42.6 ± 13.5 y, 50.6% of whom were male, took part in the study. Intervention • Participants in the intervention group (FDM group) received osteopathic manipulative treatments according to the FDM, whereas the control group (NDMG group) received an active control treatment following the NDMG. Outcome Measures • Comparing the FDM group (n = 39) and the NDMG group (n = 38), the study measured pain (visual analog scale, patient diary), functional (FFbH-R) and self-reported vocational status, and use of medication (patient diary) at baseline and after 1, 4 and 12 wk of treatment. Results • The study found marked improvements of the symptoms in both groups, with a faster onset of efficacy and significantly less medication under the FDM treatment. Conclusions • FDM appears to be effective with regard to pain relief and functional improvement for LBP.

Accuracy of single-session extracranial radiotherapy for simple shaped lung tumor or metastasis using fast 3-D CT treatment planning.

BACKGROUND: This study is situated in the area of measuring set-up accuracy and time periods of single-session extracranial radiotherapy (SSRT) for simple-shaped targets (e.g., spherical or rotational symmetrical) definitively located in the peripheral lung. METHODS AND MATERIALS: After adaptation of the stereotactic body frame, the patient has to remain in the vacuum pillow during planning computed tomography (CT), fast three-dimensional (3-D) treatment planning, and direct irradiation after verification. Fast preplanning is performed by using virtual simulation software to accelerate the method. RESULTS: In our new procedure, SSRT is applied in approximately 1.5 h. The mean setup accuracy vector was 2.4+/-0.7 mm in the range of 1.34 to 4 mm. Mean intrafractional patient movement in the stereotactic body frame before and after radiation was 0.70 mm+/-0.5 mm and 0.76+/-0.76 mm in the range of 0 to 2.8 mm. Mean time period steps were measured at (1) planning CT with 3-D treatment planning: 76+/-12 min; (2) irradiation and verification: 33+/-7 min; and (3) complete procedure duration: 109+/-11 min (range, 89-169). CONCLUSIONS: The main difference between the positioning technique of SSRT and that of conventional extracranial radiosurgery is the tighter patient fixation, which guarantees minimal patient movement. The main advantages are procedure acceleration and omission of CT simulation. SSRT is a preliminary stage of real-time treatment.

Atlas-based semiautomatic target volume definition (CTV) for head-and-neck tumors.

PURPOSE: To develop a new semiautomatic method to improve target delineation in head-and-neck cancer. METHODS AND MATERIALS: We implemented an atlas-based software program using fourteen anatomic landmarks as well as the most superior and inferior computerd tomography slices for automatic target delineation, using an advanced laryngeal carcinoma as an example. Registration was made by an affine transformation. Evaluation was performed with manually drawn contours for comparison. Three physicians sampled and further applied a target volume atlas to ten other computer tomography data sets. In addition, a rapid three-dimensional (3D) correction program was developed. RESULTS: The mean time to the first semiautomatic target delineation proposal was 2.7 minutes. Manual contouring required 20.2 minutes per target, whereas semiautomatic target volume definition with the rapid 3D correction was completed in only 9.7 minutes. The net calculation time for image registration of the target volume atlas was negligible (approximately 0.6 seconds). Our method depicted a sufficient adaptation of the target volume atlas on the new data sets, with a mean similarity index of 77.2%. The similarity index increased up to 85% after 3D correction performed by the physicians. CONCLUSIONS: We have developed a new, feasible method for semiautomatic contouring that saves a significant amount (51.8%) of target delineation time for head-and-neck cancer patients. This approach uses a target volume atlas and a landmark model. The software was evaluated by means of laryngeal cancer but has important implications for various tumor types whereby target volumes remain constant in form and do not move with respiration.

One-dimensional Fourier transformation of M-mode sonograms for frequency analysis of moving structures with application to spinal cord motion.

BACKGROUND: Movements of the spinal cord are induced by arterial pulsation and breathing. OBJECTIVE: The aim of this study was to analyse these oscillations in more detail and to classify them using one-dimensional fast Fourier transformation (1D-FFT). MATERIALS AND METHODS: A total of 153 M-mode studies in 53 patients (age 1 month to 14 years) were undertaken using a 5-MHz linear transducer (B- and M-mode). 1D-FFT was applied to the M-mode areas of digitized images. RESULTS: 1D-FFT shows characteristic patterns of spectra for groups of normal, reduced and missing cord motility. For normal cord motility, 1D-FFT peak frequency corresponded to the heart rate, and additional four to five harmonic maxima up to 11 Hz could be found. Reduced cord motility was characterised by one to three harmonic maxima; an immobile cord showed only zero to one maximum. The maximum speed of transverse motion of the neural structures in the lumbar region reached 25 mm/s. CONCLUSIONS: Using 1D-FFT, characteristic frequency patterns of spinal cord motions can be analysed. In patients with meningomyelocoele individual classification of cord motility is possible. This method of analysis may assist with recognising those at risk of developing secondary tethered cord syndrome.

Development of nephrocalcinosis in very low birth weight infants.

Premature infants undergo intensive growth during the postnatal period. Adequate mineralization is dependent on sufficient intake of calcium (Ca) and phosphorus (P). However, Ca and P supplementation can be associated with some risks, for example development of nephrocalcinosis. We investigated pathophysiological risk factors in premature very low birth weight (VLBW) infants associated with the development of nephrocalcinosis. From June 1994 to September 1995 all preterm neonates with a birth weight below 1,500 g were screened prospectively. At regular intervals of 2 weeks, ultrasonography (US) of the kidneys was performed and parameters of mineral metabolism were assessed in blood and spot urine samples. For analysis, premature infants with nephrocalcinosis (group N) were compared with infants without nephrocalcinosis (group R) and with a retrospectively pair-matched subgroup of premature infants without nephrocalcinosis (control group C) taken from the same study. Nephrocalcinosis was detected in 20 of 114 preterm neonates (group N, 17.5%). Of these 20 infants with nephrocalcinosis, 16 presented with a tendency towards systemic acidosis (pH<7.25) on day 2-7, compared with only 4 of 20 premature infants of the control group. Premature infants of group N had a lower serum P at 2 weeks of life and 5 (versus 0 patients of the control group C) had transient hypophosphatemia (serum P<1.6 mmol/l). Moreover, the Ca/creatinine ratio in spot urine specimens tended to be higher (P<0.1) in patients developing nephrocalcinosis. There were no significant differences in the duration of ventilation, the length of stay in the intensive care unit, and duration and frequency of furosemide and steroid treatment between the groups N and C. VLBW premature infants developing nephrocalcinosis frequently presented with slightly impaired acid-base homoeostasis within the 1st week, followed by signs of impaired mineralization (and immature or impaired renal function) within 2 weeks. In VLBW premature infants, close observation of acid-base status and regular analysis of spot urine specimens (Ca, P, creatinine) during the first weeks of life may help to identify those premature infants at risk for nephrocalcinosis.

Accuracy of 3-d needle navigation in interstitial brachytherapy in various body regions.

BACKGROUND: Precise immobilisation of a patient during extracranial stereotactic 3-D navigation is essential in order to minimize the patient's movement during CT data recording and needle application. In this paper we report the first results of needle positioning accuracy in various body regions, using a 3-D navigation system for brachytherapy and a new patient immobilisation system. PATIENTS AND METHODS: Six patients with different manifestations of neoplastic diseases were immobilized by a special vacuum system and treated with stereotactic 3-D navigational interstitial brachytherapy. RESULTS: The comparison of the simulated stereotactic needle positions with the actual needle positions resulted in a mean positioning deviation varying from 3.4 to 6.5 mm for 29 needles. The maximum positioning deviation lay between 5.7 and 13 mm. CONCLUSION: The results of our study show that, despite effective patient immobilisation, an increase in needle positioning accuracy is limited by the method of stereotactic 3-D navigation. Effects such as modification of body shape caused by the needle application morphologic alterations, and inherent inaccuracies within the navigation system have an important influence upon accuracy, which it is not yet possible to calculate.