Detalhe da pesquisa
1.
Population pharmacokinetic modelling and simulation of tafamidis in healthy subjects and patients with transthyretin amyloidosis.
Br J Clin Pharmacol
; 87(9): 3574-3587, 2021 09.
Artigo
Inglês
| MEDLINE | ID: mdl-33586186
2.
Who do we discharge from renal clinic and what does it mean for primary care?
Fam Pract
; 37(2): 187-193, 2020 03 25.
Artigo
Inglês
| MEDLINE | ID: mdl-31603190
3.
Impact of Phase 1 study design on estimation of QT interval prolongation risk using exposure-response analysis.
J Pharmacokinet Pharmacodyn
; 46(6): 605-616, 2019 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-31664592
4.
Cardiac risk assessment based on early Phase I data and PK-QTc analysis is concordant with the outcome of thorough QTc trials: an assessment based on eleven drug candidates.
J Pharmacokinet Pharmacodyn
; 46(6): 617-626, 2019 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-31667657
5.
Correction to: Scientific white paper on concentration-QTc modeling.
J Pharmacokinet Pharmacodyn
; 45(3): 399, 2018 06.
Artigo
Inglês
| MEDLINE | ID: mdl-29330761
6.
Scientific white paper on concentration-QTc modeling.
J Pharmacokinet Pharmacodyn
; 45(3): 383-397, 2018 06.
Artigo
Inglês
| MEDLINE | ID: mdl-29209907
7.
The effect of tafamidis on the QTc interval in healthy subjects.
Br J Clin Pharmacol
; 79(6): 918-25, 2015 06.
Artigo
Inglês
| MEDLINE | ID: mdl-25546001
8.
Cardiac Safety Research Consortium: can the thorough QT/QTc study be replaced by early QT assessment in routine clinical pharmacology studies? Scientific update and a research proposal for a path forward.
Am Heart J
; 168(3): 262-72, 2014 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-25173536
9.
The IQ-CSRC prospective clinical Phase 1 study: "Can early QT assessment using exposure response analysis replace the thorough QT study?".
Ann Noninvasive Electrocardiol
; 19(1): 70-81, 2014 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-24372708
10.
Quality-by-design: are we there yet?
AAPS PharmSciTech
; 15(1): 140-8, 2014 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-24218058
11.
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As.
J Pharmacol Toxicol Methods
; 123: 107270, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37164235
12.
Lack of an Effect of Supratherapeutic Dose of Venlafaxine on Cardiac Repolarization in Healthy Subjects.
Clin Pharmacol Drug Dev
; 11(1): 100-111, 2022 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34242472
13.
Lack of an effect of standard and supratherapeutic doses of linezolid on QTc interval prolongation.
Antimicrob Agents Chemother
; 55(9): 4302-7, 2011 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-21709083
14.
Modeling of Survival and Frequency of Cardiovascular-Related Hospitalization in Patients with Transthyretin Amyloid Cardiomyopathy Treated with Tafamidis.
Am J Cardiovasc Drugs
; 21(5): 535-543, 2021 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-33770392
15.
Drug Discovery and Development in Rare Diseases: Taking a Closer Look at the Tafamidis Story.
Drug Des Devel Ther
; 15: 1225-1243, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-33776421
16.
Predictors of Systemic Exposure to Topical Crisaborole: A Nonlinear Regression Analysis.
J Clin Pharmacol
; 60(10): 1344-1354, 2020 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32433779
17.
Evaluation of QT Liability for PF-05251749 in the Presence of Potential Circadian Rhythm Modification.
CPT Pharmacometrics Syst Pharmacol
; 9(1): 60-69, 2020 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31749321
18.
A Thorough QT Study to Evaluate the Effects of a Supratherapeutic Dose of Sertraline on Cardiac Repolarization in Healthy Subjects.
Clin Pharmacol Drug Dev
; 9(3): 307-320, 2020 04.
Artigo
Inglês
| MEDLINE | ID: mdl-31777203
19.
The Bioequivalence of Tafamidis 61-mg Free Acid Capsules and Tafamidis Meglumine 4 × 20-mg Capsules in Healthy Volunteers.
Clin Pharmacol Drug Dev
; 9(7): 849-854, 2020 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32196976
20.
Evaluation of the Effect of 5 QT-Positive Drugs on the JTpeak Interval - An Analysis of ECGs From the IQ-CSRC Study.
J Clin Pharmacol
; 60(1): 125-139, 2020 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31378962