Detalhe da pesquisa
1.
Advances in the design of new types of inhaled medicines.
Prog Med Chem
; 61: 93-162, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35753716
2.
Theoretical Studies of the Mechanism of Carbamoylation of Nucleobases by Isocyanates.
Chem Res Toxicol
; 33(11): 2845-2853, 2020 11 16.
Artigo
Inglês
| MEDLINE | ID: mdl-33076655
3.
Theoretical studies of the mechanism of N-hydroxylation of primary aromatic amines by cytochrome P450 1A2: radicaloid or anionic?
Chem Res Toxicol
; 27(2): 265-78, 2014 Feb 17.
Artigo
Inglês
| MEDLINE | ID: mdl-24410629
4.
Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism.
J Med Chem
; 66(20): 14188-14207, 2023 10 26.
Artigo
Inglês
| MEDLINE | ID: mdl-37797307
5.
Theoretical studies of chemical reactivity of metabolically activated forms of aromatic amines toward DNA.
Chem Res Toxicol
; 25(10): 2236-52, 2012 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22946514
6.
HDAC6 inhibitor ACY-1083 shows lung epithelial protective features in COPD.
PLoS One
; 17(10): e0266310, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-36223404
7.
Explanation for main features of structure-genotoxicity relationships of aromatic amines by theoretical studies of their activation pathways in CYP1A2.
J Am Chem Soc
; 133(40): 16168-85, 2011 Oct 12.
Artigo
Inglês
| MEDLINE | ID: mdl-21894985
8.
Mechanism-Based Insights into Removing the Mutagenicity of Aromatic Amines by Small Structural Alterations.
J Med Chem
; 64(12): 8545-8563, 2021 06 24.
Artigo
Inglês
| MEDLINE | ID: mdl-34110134
9.
Fragment-Based Discovery of Novel Allosteric MEK1 Binders.
ACS Med Chem Lett
; 12(2): 302-308, 2021 Feb 11.
Artigo
Inglês
| MEDLINE | ID: mdl-33603979
10.
A Phenotypic Screening Approach Using Human Treg Cells Identified Regulators of Forkhead Box p3 Expression.
ACS Chem Biol
; 14(3): 543-553, 2019 03 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30807094
11.
Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma.
J Med Chem
; 62(17): 7769-7787, 2019 09 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31415176
12.
Theoretical studies of the second step of the nitric oxide synthase reaction: Electron tunneling prevents uncoupling.
J Inorg Biochem
; 181: 28-40, 2018 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29407906
13.
Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.
J Med Chem
; 61(5): 1785-1799, 2018 03 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29424542
14.
Aryl Radical Endo Cyclization of Enamidines. Selective Preparation of Trans and Cis Fused Octahydrobenzo[f]quinolines.
J Org Chem
; 63(1): 84-91, 1998 Jan 09.
Artigo
Inglês
| MEDLINE | ID: mdl-11674046
15.
Controlled Double-Bond Migration in Palladium-Catalyzed Intramolecular Arylation of Enamidines.
J Org Chem
; 61(20): 7147-7155, 1996 Oct 04.
Artigo
Inglês
| MEDLINE | ID: mdl-11667618
16.
Intramolecular Enantioselective Palladium-Catalyzed Heck Arylation of Cyclic Enamides.
J Org Chem
; 62(3): 595-602, 1997 Feb 07.
Artigo
Inglês
| MEDLINE | ID: mdl-11671454
17.
Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites.
J Med Chem
; 52(23): 7706-23, 2009 Dec 10.
Artigo
Inglês
| MEDLINE | ID: mdl-19954248